Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature

Objective In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non‐invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study w...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of geriatric psychiatry Vol. 36; no. 3; pp. 383 - 392
Main Authors:	Overvliet, Geke M., Jansen, Rebecca A. C., van Balkom, Anton J. L. M., van Campen, Dilene C., Oudega, Mardien L., van der Werf, Ysbrand D., van Exel, Eric, van den Heuvel, Odile A., Dols, Annemiek
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-03-2021 John Wiley and Sons Inc
Subjects:	adverse events Aged Clinical trials Depression Geriatric psychiatry Humans late life depression Literature reviews Magnetic fields Mental depression Neuromodulation older adults Older people repetitive transcranial magnetic stimulation Review serious adverse events Suicide Systematic review Transcranial Magnetic Stimulation Treatment Outcome serious adverse events older adults adverse events late life depression repetitive transcranial magnetic stimulation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non‐invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (serious) AE of rTMS in older adults (>60 years) with late‐life depression (LLD). Methods A systematic search has been performed according to the PRISMA guidelines in PubMed, EMBase and PsycInfo. We have screened 622 articles for eligibility. Eleven studies, evaluating 353 patients in total, were included in this review. Results AE were reported in 12.4% of the older adults with a LLD treated with rTMS, serious AE in 1.5%. Headache (6.9%) and discomfort at the stimulation site (2.7%) are the most commonly reported AE. Serious AE reported are: psychiatric hospitalization (three times), a combination of posterior vitreous detachment and retinal tear, and increased suicide ideation (both once). Conclusions rTMS in older adults with LLD was concluded overall to be safe due to the low frequency of AE reported in trials and observational studies. In case‐reports, however, more serious AE have been described. To tailor use of rTMS in older adults with LLD, more research is needed in larger samples to optimize tolerance. Highlights Little is known about (serious) AE of rTMS in older adults (>60 years) with LLD. A relatively low percentage of AE (12.4% in total) and serious AE (1.5% in total) in response to rTMS occurs in older adults with LLD. rTMS is a safe and well‐tolerated treatment option for older adults with LLD.
Bibliography:	SourceType-Scholarly Journals-1 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23 ObjectType-Review-2 ObjectType-Article-3
ISSN:	0885-6230 1099-1166
DOI:	10.1002/gps.5440