Search Results - "van Buul, Jaap D."

A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium by van der Linden, Franka H., Mahlandt, Eike K., Arts, Janine J. G., Beumer, Joep, Puschhof, Jens, de Man, Saskia M. A., Chertkova, Anna O., Ponsioen, Bas, Clevers, Hans, van Buul, Jaap D., Postma, Marten, Gadella, Theodorus W. J., Goedhart, Joachim

“…The most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in…”
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The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models by Klems, Alina, van Rijssel, Jos, Ramms, Anne S., Wild, Raphael, Hammer, Julia, Merkel, Melanie, Derenbach, Laura, Préau, Laetitia, Hinkel, Rabea, Suarez-Martinez, Irina, Schulte-Merker, Stefan, Vidal, Ramon, Sauer, Sascha, Kivelä, Riikka, Alitalo, Kari, Kupatt, Christian, van Buul, Jaap D., le Noble, Ferdinand

“…Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery…”
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Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength by Mahlandt, Eike K, Palacios Martínez, Sebastián, Arts, Janine J G, Tol, Simon, van Buul, Jaap D, Goedhart, Joachim

“…The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly…”
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Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium by Rademakers, Timo, Goedhart, Marieke, Hoogenboezem, Mark, García Ponce, Alexander, van Rijssel, Jos, Samus, Maryna, Schnoor, Michael, Butz, Stefan, Huveneers, Stephan, Vestweber, Dietmar, Nolte, Martijn A, Voermans, Carlijn, van Buul, Jaap D

“…Bone marrow endothelium plays an important role in the homing of hematopoietic stem and progenitor cells upon transplantation, but surprisingly little is known…”
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The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis by Kempers, Lanette, Wakayama, Yuki, van der Bijl, Ivo, Furumaya, Charita, De Cuyper, Iris M., Jongejan, Aldo, Kat, Marije, van Stalborch, Anne-Marieke D., van Boxtel, Antonius L., Hubert, Marvin, Geerts, Dirk, van Buul, Jaap D., de Korte, Dirk, Herzog, Wiebke, Margadant, Coert

“…Sprouting angiogenesis is key to many pathophysiological conditions, and is strongly regulated by vascular endothelial growth factor (VEGF) signaling through…”
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Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration by Arts, Janine JG, Mahlandt, Eike K, Grönloh, Max LB, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham CI, Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A, Postma, Marten, Khuon, Satya, Heddleston, John M, Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim, van Buul, Jaap D

“…Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit…”
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Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking by Daniel, Anna E, Timmerman, Ilse, Kovacevic, Igor, Hordijk, Peter L, Adriaanse, Luc, Paatero, Ilkka, Belting, Heinz-Georg, van Buul, Jaap D

“…Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a…”
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Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen by Goedhart, Marieke, Slot, Edith, Pascutti, Maria F, Geerman, Sulima, Rademakers, Timo, Nota, Benjamin, Huveneers, Stephan, Buul, Jaap D van, MacNamara, Katherine C, Voermans, Carlijn, Nolte, Martijn A

“…Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident…”
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Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans by van der Valk, Fleur M, Bekkering, Siroon, Kroon, Jeffrey, Yeang, Calvin, Van den Bossche, Jan, van Buul, Jaap D, Ravandi, Amir, Nederveen, Aart J, Verberne, Hein J, Scipione, Corey, Nieuwdorp, Max, Joosten, Leo A.B, Netea, Mihai G, Koschinsky, Marlys L, Witztum, Joseph L, Tsimikas, Sotirios, Riksen, Niels P, Stroes, Erik S.G

“…BACKGROUND:Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its…”
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The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis by Samson, Thomas, van Buul, Jaap D, Kroon, Jeffrey, Welch, Christopher, Bakker, Erik N, Matlung, Hanke L, van den Berg, Timo K, Sharek, Lisa, Doerschuk, Claire, Hahn, Klaus, Burridge, Keith

“…The passage of leukocytes across the endothelium and into arterial walls is a critical step in the development of atherosclerosis. Previously, we showed in…”
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Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation by van Buul, Jaap D., Voisin, Mathieu-Benoit, Alcaide, Pilar, Schnoor, Michael

“…Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules…”
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ICAM-1-Mediated, Src- and Pyk2-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation Is Required for Leukocyte Transendothelial Migration by Allingham, Michael J, van Buul, Jaap D, Burridge, Keith

“…Leukocyte transendothelial migration (TEM) has been modeled as a multistep process beginning with rolling adhesion, followed by firm adhesion, and ending with…”
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F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling by Heemskerk, Niels, Schimmel, Lilian, Oort, Chantal, van Rijssel, Jos, Yin, Taofei, Ma, Bin, van Unen, Jakobus, Pitter, Bettina, Huveneers, Stephan, Goedhart, Joachim, Wu, Yi, Montanez, Eloi, Woodfin, Abigail, van Buul, Jaap D.

“…During immune surveillance and inflammation, leukocytes exit the vasculature through transient openings in the endothelium without causing plasma leakage…”
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A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 by Timmerman, Ilse, Heemskerk, Niels, Kroon, Jeffrey, Schaefer, Antje, van Rijssel, Jos, Hoogenboezem, Mark, van Unen, Jakobus, Goedhart, Joachim, Gadella, Jr, Theodorus W J, Yin, Taofei, Wu, Yi, Huveneers, Stephan, van Buul, Jaap D

“…Endothelial cell-cell junctions maintain a restrictive barrier that is tightly regulated to allow dynamic responses to permeability-inducing angiogenic…”
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Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis by Park, Hongryeol, Song, Jian, Jeong, Hyun-Woo, Grönloh, Max L. B., Koh, Bong Ihn, Bovay, Esther, Kim, Kee-Pyo, Klotz, Luisa, Thistlethwaite, Patricia A., van Buul, Jaap D., Sorokin, Lydia, Adams, Ralf H.

“…Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and…”
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Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis by Sluiter, Thijs J, van Buul, Jaap D, Huveneers, Stephan, Quax, Paul H A, de Vries, Margreet R

“…The vascular endothelium is a highly specialized barrier that controls passage of fluids and migration of cells from the lumen into the vessel wall…”
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Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration by Schaefer, Antje, Te Riet, Joost, Ritz, Katja, Hoogenboezem, Mark, Anthony, Eloise C, Mul, Frederik P J, de Vries, Carlie J, Daemen, Mat J, Figdor, Carl G, van Buul, Jaap D, Hordijk, Peter L

“…Chronic vascular inflammation is driven by interactions between activated leukocytes and the endothelium. Leukocyte β2-integrins bind to endothelial…”
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Protocol to analyze transmigration of human cytotoxic T cells under physiological flow conditions in vitro by Schoppmeyer, Rouven, van Buul, Jaap D.

“…This protocol presents an assay for transmigration analysis of human cytotoxic T cells (CTL) under physiological flow in vitro. We describe detailed analysis…”
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Diabetes Mellitus Induces Bone Marrow Microangiopathy by Oikawa, Atsuhiko, Siragusa, Mauro, Quaini, Federico, Mangialardi, Giuseppe, Katare, Rajesh G, Caporali, Andrea, van Buul, Jaap D, van Alphen, Floris P.J, Graiani, Gallia, Spinetti, Gaia, Kraenkel, Nicolle, Prezioso, Lucia, Emanueli, Costanza, Madeddu, Paolo

“…OBJECTIVE—The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular…”
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Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions by van Buul, Jaap D., Timmerman, Ilse

“…VE-cadherin-based cell-cell junctions form the major restrictive barrier of the endothelium to plasma proteins and blood cells. The function of VE-cadherin and…”
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