Search Results - "van Breda, Simone G"

Author Correction: Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx by He, Yueqin, DeBenedictis, Julia Nicole, Caiment, Florian, van Breda, Simone G. J., de Kok, Theo M. C. M.

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Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx by He, Yueqin, DeBenedictis, Julia Nicole, Caiment, Florian, van Breda, Simone G. J., de Kok, Theo M. C. M.

“…Diet is an important determinant of overall health, and has been linked to the risk of various cancers. To understand the mechanisms involved, transcriptomic…”
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Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals by van Breda, Simone G J, Briedé, Jacob J, de Kok, Theo M C M

“…Blueberries contain many different phytochemicals which might be responsible for their disease preventive properties. In a previously conducted human dietary…”
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Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System by Bischoff, Nicolaj S, de Kok, Theo M, Sijm, Dick T H M, van Breda, Simone G, Briedé, Jacco J, Castenmiller, Jacqueline J M, Opperhuizen, Antoon, Chirino, Yolanda I, Dirven, Hubert, Gott, David, Houdeau, Eric, Oomen, Agnes G, Poulsen, Morten, Rogler, Gerhard, van Loveren, Henk

“…Titanium dioxide (TiO ) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as…”
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Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases by Breda, Simone G.J., Kok, Theo M.C.M.

“…There is ample scientific evidence suggesting that the health benefits of eating the right amounts of a variety of vegetables and fruit are the consequence of…”
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Mechanisms of combined action of different chemopreventive dietary compounds by de Kok, Theo M, van Breda, Simone G, Manson, Margaret M

“…Consumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous…”
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Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers by van Breda, Simone G, Mathijs, Karen, Sági-Kiss, Virág, Kuhnle, Gunter G, van der Veer, Ben, Jones, Rena R, Sinha, Rashmi, Ward, Mary H, de Kok, Theo M

“…Nitrate is converted to nitrite in the human body and subsequently can react with amines and amides in the gastrointestinal tract to form N-nitroso compounds…”
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Genetic Variability Impacts Genotoxic and Transcriptome Responses in the Human Colon after the Consumption of Processed Red Meat Products and Those with Added Phytochemical Extracts by DeBenedictis, Julia N, Baars, Esther, Ochoteco-Asensio, Juan, van Breda, Simone G, de Kok, Theo M

“…The PHYTOME study investigated the effect of consuming processed meat products on outcomes related to colorectal cancer risk without testing the impact of…”
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Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes by Wolters, Jarno E. J, van Breda, Simone G. J, Caiment, Florian, Claessen, Sandra M, de Kok, Theo M. C. M, Kleinjans, Jos C. S

“…Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity…”
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Impact of Processing Method and Storage Time on Phytochemical Concentrations in an Antioxidant-Rich Food Mixture by DeBenedictis, Julia N, de Kok, Theo M, van Breda, Simone G

“…Foods high in phytochemicals are known for their role in the prevention of chronic disease development, but after processing and storage, such food products…”
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Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial by DeBenedictis, Julia N, Murrell, Courtney, Hauser, Duncan, van Herwijnen, Marcel, Elen, Bart, de Kok, Theo M, van Breda, Simone G

“…Adequate fruit and vegetable (F and V) intake, as recommended by the World Health Organization (over 400 g/day), is linked to reduced chronic disease risk…”
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Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma by Rieswijk, Linda, Claessen, Sandra M.H, Bekers, Otto, Herwijnen, Marcel van, Theunissen, Daniël H.J, Jennen, Danyel G.J, de Kok, Theo M.C.M, Kleinjans, Jos C.S, van Breda, Simone G.J

“…Abstract Chronic exposure to aflatoxin B1 (AFB1) has, in certain regions in the world, been strongly associated with hepatocellular carcinoma (HCC)…”
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Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis by van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.

“…Arsenic is an established human carcinogen, but the mechanisms through which it contributes to for instance lung cancer development are still unclear. As…”
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Integrative “‑Omics” Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A‑Induced Cholestasis by Wolters, Jarno E. J, van Herwijnen, Marcel H. M, Theunissen, Daniel H. J, Jennen, Danyel G. J, Van den Hof, Wim F. P. M, de Kok, Theo M. C. M, Schaap, Frank G, van Breda, Simone G. J, Kleinjans, Jos C. S

“…Cyclosporine A (CsA) is an undecapeptide with strong immunosuppressant activities and is used a lot after organ transplantation. Furthermore, it may induce…”
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Potential protein markers for nutritional health effects on colorectal cancer in the mouse as revealed by proteomics analysis by Breikers, Githa, van Breda, Simone G. J., Bouwman, Freek G., van Herwijnen, Marcel H. M., Renes, Johan, Mariman, Edwin C. M., Kleinjans, Jos C. S., van Delft, Joost H. M.

“…It is suggested that colorectal cancer might be prevented by changes in diet, and vegetable consumption has been demonstrated to have a protective effect…”
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Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N -nitroso Compounds in Humans by Berends, Julia E, van den Berg, Lauri M M, Guggeis, Martina A, Henckens, Nikki F T, Hossein, Israt J, de Joode, Minke E J R, Zamani, Hossy, van Pelt, Kirsten A A J, Beelen, Nicky A, Kuhnle, Gunter G, de Kok, Theo M C M, Van Breda, Simone G J

“…Consumption of nitrate-rich beetroot juice (BRJ) by athletes induces a number of beneficial physiological health effects, which are linked to the formation of…”
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The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer by Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M

“…Titanium dioxide (TiO ) is present in many different food products as the food additive E171, which is currently scrutinized due to its potential adverse…”
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Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake by van Breda, Simone G. J., van Delft, Joost H. M., Engels, Leopold G. J. B., Kleinjans, Jos C. S., Mathers, John C.

“…Vegetables may protect against colorectal cancer (CRC) via changes in gene expression involved in anticarcinogenic mechanisms. There is considerable evidence…”
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Reply to Kaminski, N.E.; Cohen, S.M. Comment on "Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12 , 1256" by Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M

“…We appreciate the interest in our article describing transcriptome changes in a transgenic mouse model carrying an APC gene mutation and would like to reply to…”
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Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: The value of genomics biomarkers in molecular epidemiology by de Kok, Theo M.C.M, de Waard, Pim, Wilms, Lonneke C, van Breda, Simone G.J

“…There is considerable evidence that consumption of fruits and vegetables may contribute to the prevention of cancer. It is however remarkable that evidence for…”
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