Search Results - "van Borren, Marcel M.G.J."

Ae2a,b-Deficient mice exhibit osteopetrosis of long bones but not of calvaria by Jansen, Ineke D.C, Mardones, Pablo, Lecanda, Fernando, de Vries, Teun J, Recalde, Sergio, Hoeben, Kees A, Schoenmaker, Ton, Ravesloot, Jan-Hindrik, van Borren, Marcel M.G.J, van Eijden, Theo M, Bronckers, Antonius L.J.J, Kellokumpu, Sakari, Medina, Juan F, Everts, Vincent, Oude Elferink, Ronald P.J

“…Extracellular acidification by osteoclasts is essential to bone resorption. During proton pumping, intracellular pH (pHi) is thought to be kept at a…”
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Is sodium current present in human sinoatrial node cells? by Verkerk, Arie O, Wilders, Ronald, van Borren, Marcel M G J, Tan, Hanno L

“…Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown…”
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NHE-1 and NBC during pseudo-ischemia/reperfusion in rabbit ventricular myocytes by van Borren, Marcel M.G.J, Baartscheer, Antonius, Wilders, Ronald, Ravesloot, Jan H

“…Despite many studies into the pathophysiology of cardiac ischemia–reperfusion injury, a number of key details are as yet undisclosed. These include the timing…”
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Activated human platelet products induce proarrhythmic effects in ventricular myocytes by de Jong, Jonas S.S.G, Verkerk, Arie O, van Borren, Marcel M.G.J, Zakhrabova - Zwiauer, Olga M, Nieuwland, Rienk, Meijers, Joost C.M, Akkerman, Jan-Willem N, Wilde, Arthur A.M, Tan, Hanno L, Dekker, Lukas R.C

“…Abstract Sudden cardiac death remains one of the most prevalent modes of death and is mainly caused by ventricular fibrillation (VF) in the setting of acute…”
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A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays by Ni, Yan, Rosier, Bas J. H. M., van Aalen, Eva A., Hanckmann, Eva T. L., Biewenga, Lieuwe, Pistikou, Anna-Maria Makri, Timmermans, Bart, Vu, Chris, Roos, Sophie, Arts, Remco, Li, Wentao, de Greef, Tom F. A., van Borren, Marcel M. G. J., van Kuppeveld, Frank J. M., Bosch, Berend-Jan, Merkx, Maarten

“…Heterogeneous immunoassays such as ELISA have become indispensable in modern bioanalysis, yet translation into point-of-care assays is hindered by their…”
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Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation by van der Veer, Harmen J., van Aalen, Eva A., Michielsen, Claire M. S., Hanckmann, Eva T. L., Deckers, Jeroen, van Borren, Marcel M. G. J., Flipse, Jacky, Loonen, Anne J. M., Schoeber, Joost P. H., Merkx, Maarten

“…Nucleic acid detection methods based on CRISPR and isothermal amplification techniques show great potential for point-of-care diagnostic applications. However,…”
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Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery by Deden, Laura N., Aarts, Edo O., Aelfers, Stephanie C. W., van Borren, Marcel M. G. J., Janssen, Ignace M. C., Berends, Frits J., de Boer, Hans

“…Background Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB)…”
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Pacemaker current (If) in the human sinoatrial node by Verkerk, Arie O., Wilders, Ronald, van Borren, Marcel M.G.J., Peters, Ron J.G., Broekhuis, Eli, Lam, Kayan, Coronel, Ruben, de Bakker, Jacques M.T., Tan, Hanno L.

“…Aims Animal studies revealed that the hyperpolarization-activated pacemaker current, If, contributes to action potential (AP) generation in sinoatrial node…”
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Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes by Casini, Simona, Verkerk, Arie O., van Borren, Marcel M.G.J., van Ginneken, Antoni C.G., Veldkamp, Marieke W., de Bakker, Jacques M.T., Tan, Hanno L.

“…Aims Cardiac voltage-gated sodium channels control action potential (AP) upstroke and cell excitability. Intracellular calcium (Cai2+) regulates AP properties…”
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Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells by Verkerk, Arie O, van Borren, Marcel M G J, van Ginneken, Antoni C G, Wilders, Ronald

“…In animal models of heart failure (HF), heart rate decreases due to an increase in intrinsic cycle length (CL) of the sinoatrial node (SAN). Pacemaker activity…”
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Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure by BAARTSCHEER, Antonius, SCHUMACHER, Cees A, VAN BORREN, Marcel M. G. J, BELTERMAN, Charly N. W, CORONEL, Ruben, OPTHOF, Tobias, FIOLET, Jan W. T

“…In patients with heart disease, the transition from compensatory hypertrophy to heart failure (HF) is associated with altered calcium handling. Up-regulated…”
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Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells by Verkerk, Arie O., Wilders, Ronald, van Borren, Marcel M. G. J.

“…There is an ongoing debate on the mechanism underlying the pacemaker activity of sinoatrial node (SAN) cells, focusing on the relative importance of the…”
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Sodium ion transporters as new therapeutic targets in heart failure by Baartscheer, Antonius, van Borren, Marcel M G J

“…Sodium ion transporters in sarcolemma are involved in numerous vital cell functions, such as excitability, excitation-contraction coupling, energy metabolism,…”
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Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block by van Borren, Marcel M G J, Vos, Marc A, Houtman, Marien J C, Antoons, Gudrun, Ravesloot, Jan H

“…Dogs with compensated biventricular hypertrophy due to chronic atrioventricular block (cAVB), are more susceptible to develop drug-induced Torsade-de-Pointes…”
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Dietary Omega-3 Polyunsaturated Fatty Acids Suppress NHE-1 Upregulation in a Rabbit Model of Volume- and Pressure-Overload by van Borren, Marcel M G J, den Ruijter, Hester M, Baartscheer, Antonius, Ravesloot, Jan H, Coronel, Ruben, Verkerk, Arie O

“…Increased consumption of omega-3 polyunsaturated fatty acids (ω3-PUFAs) from fish oil (FO) may have cardioprotective effects during ischemia/reperfusion,…”
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Contribution of NHE-1 to cell length shortening of normal and failing rabbit cardiac myocytes by van Borren, Marcel M.G.J., Zegers, Jan G., Baartscheer, Antonius, Ravesloot, Jan H.

“…At the same intracellular pH (pH i ) Na +/H + exchange (NHE-1) fluxes of ventricular myocytes of hypertrophied failing hearts (HFH) are increased. We assessed…”
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Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells by Verkerk, Arie O., van Borren, Marcel M. G. J., van Ginneken, Antoni C. G., Wilders, Ronald

“…Background: In animal models of heart failure (HF), heart rate decreases due to an increase in intrinsic cycle length (CL) of the sinoatrial node (SAN)…”
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Ca(2+)-activated Cl(-) current in rabbit sinoatrial node cells by Verkerk, Arie O, Wilders, Ronald, Zegers, Jan G, van Borren, Marcel M G J, Ravesloot, Jan H, Verheijck, E Etienne

“…The Ca(2+)-activated Cl(-) current (I(Cl(Ca))) has been identified in atrial, Purkinje and ventricular cells, where it plays a substantial role in phase-1…”
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Reduced swelling-activated Cl- current densities in hypertrophied ventricular myocytes of rabbits with heart failure by VAN BORREN, Marcel M. G. J, VERKERK, Arie O, VANHARANTA, Sakari K, BAARTSCHEER, Antonius, CORONEL, Ruben, RAVESLOOT, Jan H

“…Hypertrophied myocytes of failing hearts have prolonged action potential durations. It is unknown how the swelling-activated Cl(-) current (I(Cl,swell))…”
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Single Cells Isolated from Human Sinoatrial Node: Action Potentials and Numerical Reconstruction of Pacemaker Current by Verkerk, A.O., van Borren, M.M.G., Peters, R.J.G., Broekhuis, E., Lam, K.Y., Coronel, R., de Bakker, J.M.T., Tan, H.L., Wilders, R.

“…Pacemaker activity of the sinoatrial node has extensively been studied in laboratory animals of various species, but is virtually unexplored in man. Most…”
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