Search Results - "van Bezu, Jan"

Dasatinib increases endothelial permeability leading to pleural effusion by Phan, Carole, Jutant, Etienne-Marie, Tu, Ly, Thuillet, Raphaël, Seferian, Andrei, Montani, David, Huertas, Alice, Bezu, Jan van, Breijer, Fabian, Vonk Noordegraaf, Anton, Humbert, Marc, Aman, Jurjan, Guignabert, Christophe

“…Pleural effusion is a frequent side-effect of dasatinib, a second-generation tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukaemia…”
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CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity by Majolée, Jisca, Pronk, Manon C. A., Jim, Kin K., van Bezu, Jan S. M., van der Sar, Astrid M., Hordijk, Peter L., Kovačević, Igor

“…RhoGTPases regulate cytoskeletal dynamics, migration and cell-cell adhesion in endothelial cells. Besides regulation at the level of guanine nucleotide…”
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Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity by Botros, Liza, Pronk, Manon C A, Juschten, Jenny, Liddle, John, Morsing, Sofia K H, van Buul, Jaap D, Bates, Robert H, Tuinman, Pieter R, van Bezu, Jan S M, Huveneers, Stephan, Bogaard, Harm Jan, van Hinsbergh, Victor W M, Hordijk, Peter L, Aman, Jurjan

“…Endothelial barrier dysfunction leads to edema and vascular leak, causing high morbidity and mortality. Previously, Abl kinase inhibition has been shown to…”
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FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB by Pronk, Manon C A, Majolée, Jisca, Loregger, Anke, van Bezu, Jan S M, Zelcer, Noam, Hordijk, Peter L, Kovačević, Igor

“…Rho GTPases control both the actin cytoskeleton and adherens junction stability and are recognized as essential regulators of endothelial barrier function…”
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RhoA, RhoB and RhoC differentially regulate endothelial barrier function by Pronk, Manon C. A., van Bezu, Jan S. M., van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W. M., Hordijk, Peter L.

“…RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining endothelial barrier function. RhoA is most extensively…”
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Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain by van der Wijk, Anne-Eva, Georgakopoulou, Theodosia, Majolée, Jisca, van Bezu, Jan S M, van der Stoel, Miesje M, van Het Hof, Bert J, de Vries, Helga E, Huveneers, Stephan, Hordijk, Peter L, Bakker, Erik N T P, van Bavel, Ed

“…Considering its intolerance to ischemia, it is of critical importance for the brain to efficiently process microvascular occlusions and maintain tissue…”
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Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib by AMAN, Jurjan, BEZU, Jan Van, DAMANAFSHAN, Amin, HUVENEERS, Stephan, ERINGA, Etto C, VOGEL, Steven M, JOHAN GROENEVELD, A. B, VONK NOORDEGRAAF, Anton, HINSBERGH, Victor W. M. Van, NIEUW AMERONGEN, Geerten P. Van

“…Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific…”
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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces by Krishnan, Ramaswamy, Klumpers, Darinka D, Park, Chan Y, Rajendran, Kavitha, Trepat, Xavier, van Bezu, Jan, van Hinsbergh, Victor W M, Carman, Christopher V, Brain, Joseph D, Fredberg, Jeffrey J, Butler, James P, van Nieuw Amerongen, Geerten P

“…A hallmark of many, sometimes life-threatening, inflammatory diseases and disorders is vascular leakage. The extent and severity of vascular leakage is broadly…”
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Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation by Amado-Azevedo, Joana, van Stalborch, Anne-Marieke D., Valent, Erik T., Nawaz, Kalim, van Bezu, Jan, Eringa, Etto C., Hoevenaars, Femke P. M., De Cuyper, Iris M., Hordijk, Peter L., van Hinsbergh, Victor W. M., van Nieuw Amerongen, Geerten P., Aman, Jurjan, Margadant, Coert

“…Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute…”
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Correction to: Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation by Amado-Azevedo, Joana, van Stalborch, Anne-Marieke D., Valent, Erik T., Nawaz, Kalim, van Bezu, Jan, Eringa, Etto C., Hoevenaars, Femke P. M., De Cuyper, Iris M., Hordijk, Peter L., van Hinsbergh, Victor W. M., van Nieuw Amerongen, Geerten P., Aman, Jurjan, Margadant, Coert

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Transient Intervals of Hyper-Gravity Enhance Endothelial Barrier Integrity: Impact of Mechanical and Gravitational Forces Measured Electrically by Szulcek, Robert, van Bezu, Jan, Boonstra, Johannes, van Loon, Jack J W A, van Nieuw Amerongen, Geerten P

“…Endothelial cells (EC) guard vascular functions by forming a dynamic barrier throughout the vascular system that sensitively adapts to 'classical'…”
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ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension by Beckers, Cora M.L, Knezevic, Nebojsa, Valent, Erik T, Tauseef, Mohammad, Krishnan, Ramaswamy, Rajendran, Kavitha, Hardin, C. Corey, Aman, Jurjan, van Bezu, Jan, Sweetnam, Paul, van Hinsbergh, Victor W.M, Mehta, Dolly, van Nieuw Amerongen, Geerten P

“…Abstract Rho kinase mediates the effects of inflammatory permeability factors by increasing actomyosin-generated traction forces on endothelial adherens…”
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Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells by van der Heijden, Melanie, van Nieuw Amerongen, Geerten P, van Bezu, Jan, Paul, Marinus A, Groeneveld, A B Johan, van Hinsbergh, Victor W M

“…Angiopoietin-2 (Ang-2) is associated with lung injury in ALI/ARDS. As endothelial activation by thrombin plays a role in the permeability of acute lung injury…”
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Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells by Schalkwijk, Casper G., van Bezu, Jan, van der Schors, Roel C., Uchida, Koji, Stehouwer, Coen D.A., van Hinsbergh, Victor W.M.

“…In endothelial cells cultured under high glucose conditions, methylglyoxal is the major intracellular precursor in the formation of advanced glycation…”
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Reply to " STOX1 is not imprinted and is not likely to be involved in preeclampsia" by van Dijk, Marie, van Bezu, Jan, Chim, Stephen S, Lo, Y M Dennis, Blankenstein, Marinus A, Oudejans, Cees B M

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Stabilization of cell–cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function by Vila Cuenca, Marc, van Bezu, Jan, Beelen, Rob H J, Vervloet, Marc G, Hordijk, Peter L

“…Abstract Background Uraemia induces endothelial cell (EC) injury and impaired repair capacity, for which the underlying mechanism remains unclear. Active…”
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The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by α-T-catenin upregulation by van Dijk, Marie, van Bezu, Jan, van Abel, Daan, Dunk, Caroline, Blankenstein, Marinus A., Oudejans, Cees B.M., Lye, Stephen J.

“…By using complementary in vitro and ex vivo approaches, we show that the risk allele (Y153H) of the pre-eclampsia susceptibility gene STOX1 negatively…”
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THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE-/- mice by Haasdijk, Remco A, Den Dekker, Wijnand K, Cheng, Caroline, Tempel, Dennie, Szulcek, Robert, Bos, Frank L, Hermkens, Dorien M A, Chrifi, Ihsan, Brandt, Maarten M, Van Dijk, Chris, Xu, Yan Juan, Van De Kamp, Esther H M, Blonden, Lau A J, Van Bezu, Jan, Sluimer, Judith C, Biessen, Erik A L, Van Nieuw Amerongen, Geerten P, Duckers, Henricus J

“…Impairment of the endothelial barrier leads to microvascular breakdown in cardiovascular disease and is involved in intraplaque haemorrhaging and the…”
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Rac1 as a Potential Pharmacodynamic Biomarker for Thiopurine Therapy in Inflammatory Bowel Disease by Seinen, Margien L, van Nieuw Amerongen, Geerten P, de Boer, Nanne K H, Mulder, Chris J J, van Bezu, Jan, van Bodegraven, Adriaan A

“…Azathioprine and mercaptopurine (MP) are effective in treating patients with inflammatory bowel disease (IBD). Immunosuppressive effects of thiopurines involve…”
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Abstract 224: The Tyrosine Kinase Arg Mediates Endothelial Barrier Disruption by Modulating Integrin Distribution by Van Nieuw Amerongen, Geerten P, Aman, Jurjan, van Bezu, Jan, Valent, Erik, van Hinsbergh, Victor

“…Abstract only Introduction Endothelial barrier disruption and vascular leakage during inflammation forms an important threat to the critically ill. In a recent…”
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