Search Results - "van Bezooijen, Rutger"

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation by Poole, Kenneth E. S, Bezooijen, Rutger L. van, Loveridge, Nigel, Hamersma, Herman, Papapoulos, Socrates E, Löwik, Clemens W, Reeve, Jonathan

“…ABSTRACTOsteocytes are the most abundant cells in bone and are ideally located to influence bone turnover through their syncytial relationship with surface…”
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Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways by Krause, Carola, Korchynskyi, Olexandr, de Rooij, Karien, Weidauer, Stella E., de Gorter, David J.J., van Bezooijen, Rutger L., Hatsell, Sarah, Economides, Aris N., Mueller, Thomas D., Löwik, Clemens W.G.M., ten Dijke, Peter

“…Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity,…”
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SOST/sclerostin, an osteocyte-derived negative regulator of bone formation by Bezooijen, Rutger L. van, Dijke, Peter ten, Papapoulos, Socrates E., G.M. Löwik, Clemens W.

“…Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to increased bone formation…”
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Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A by Deckers, Martine M. L, van Bezooijen, Rutger L, van der Horst, Geertje, Hoogendam, Jakomijn, van der Bent, Chris, Papapoulos, Socrates E, Löwik, Clemens W. G. M

“…During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed that vascular endothelial…”
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Downregulation of Wnt Signaling by Increased Expression of Dickkopf‐1 and ‐2 is a Prerequisite for Late‐Stage Osteoblast Differentiation of KS483 Cells by van der Horst, Geertje, van der Werf, Steffie M, Farih‐Sips, Hetty, van Bezooijen, Rutger L, Löwik, Clemens WGM, Karperien, Marcel

“…We examined the role of Wnt/β‐catenin signaling in successive stages of osteoblast differentiation. It has been shown that Wnt signaling in mature osteoblasts…”
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Bone Mineral Density in Sclerosteosis; Affected Individuals and Gene Carriers by Gardner, Jessica C., van Bezooijen, Rutger L., Mervis, Benjamin, Hamdy, Neveen A. T., Löwik, Clemens W. G. M., Hamersma, Herman, Beighton, Peter, Papapoulos, Socrates E.

“…Background: Sclerosteosis is an autosomal recessive sclerosing bone disorder due to deficiency of sclerostin, a protein secreted by the osteocytes that…”
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Lack of Noggin Expression by Cancer Cells Is a Determinant of the Osteoblast Response in Bone Metastases by Schwaninger, Ruth, Rentsch, Cyrill A, Wetterwald, Antoinette, van der Horst, Geertje, van Bezooijen, Rutger L, van der Pluijm, Gabri, Löwik, Clemens W.G.M, Ackermann, Karin, Pyerin, Walter, Hamdy, Freddie C, Thalmann, George N, Cecchini, Marco G

“…Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear. Bone morphogenetic…”
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Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt Signaling by TEN DIJKE, Peter, KRAUSE, Carola, DE GORTER, David J. J, LÖWIK, Clemens W. G. M, VAN BEZOOIJEN, Rutger L

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Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover by van Lierop, Antoon H, Hamdy, Neveen AT, Hamersma, Herman, van Bezooijen, Rutger L, Power, Jon, Loveridge, Nigel, Papapoulos, Socrates E

“…Sclerosteosis is a rare bone sclerosing dysplasia, caused by loss‐of‐function mutations in the SOST gene, encoding sclerostin, a negative regulator of bone…”
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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis by Scharpfenecker, Marion, van Dinther, M, Liu, Zhen, van Bezooijen, R.L, Zhao, Qinghai, Pukac, Laurie, Löwik, Clemens W.G.M, ten Dijke, P

“…Genetic studies in mice and humans have shown that the transforming growth factor-β (TGF-β) type-I receptor activin receptor-like kinase 1 (ALK1) and its…”
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Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt Signaling by ten Dijke, Peter, Krause, Carola, de Gorter, David J J, Löwik, Clemens W.G.M, van Bezooijen, Rutger L

“…Sclerosteosis and Van Buchem disease are rare, high-bone-mass disorders that have been linked to deficiency in the SOST gene, encoding sclerostin. Sclerostin…”
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Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist by van Bezooijen, Rutger L, Roelen, Bernard A J, Visser, Annemieke, van der Wee-Pals, Lianne, de Wilt, Edwin, Karperien, Marcel, Hamersma, Herman, Papapoulos, Socrates E, ten Dijke, Peter, Löwik, Clemens W G M

“…Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product,…”
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Effect of ultraviolet light on mood, depressive disorders and well‐being by Veleva, Bistra I., Bezooijen, Rutger L., Chel, Victor G. M., Numans, Mattijs E., Caljouw, Monique A. A.

“…Summary Background Human and animal studies have shown that exposure to ultraviolet light can incite a chain of endocrine, immunologic, and neurohumoral…”
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Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation by van Bezooijen, Rutger L, Svensson, J Peter, Eefting, Daniël, Visser, Annemieke, van der Horst, Geertje, Karperien, Marcel, Quax, Paul HA, Vrieling, Harry, Papapoulos, Socrates E, ten Dijke, Peter, Löwik, Clemens WGM

“…Sclerostin is an osteocyte‐derived negative regulator of bone formation. It inhibits BMP‐stimulated bone formation both in vitro and in vivo but has no direct…”
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SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development by van Bezooijen, Rutger L., DeRuiter, Marco C., Vilain, Nathalie, Monteiro, Rui M., Visser, Annemieke, van der Wee‐Pals, Lianne, van Munsteren, Conny J., Hogendoorn, Pancras C.W., Aguet, Michel, Mummery, Christine L., Papapoulos, Socrates E., Ten Dijke, Peter, Löwik, Clemens W.G.M.

“…Spatial–temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of…”
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Osteocyte recruitment declines as the osteon fills in: Interacting effects of osteocytic sclerostin and previous hip fracture on the size of cortical canals in the femoral neck by Power, Jon, Doube, Michael, van Bezooijen, Rutger L, Loveridge, Nigel, Reeve, Jonathan

“…Abstract There is little information on the distribution of osteocytes within the individual cortical osteon, but using direct 3-D imaging in a single subject,…”
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Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential by in 't Anker, PS, Noort, WA, Scherjon, SA, Kleijburg-van der Keur, C, Kruisselbrink, AB, van Bezooijen, RL, Beekhuizen, W, Willemze, R, Kanhai, HH, Fibbe, WE

“…Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands. BACKGROUND AND OBJECTIVES: We previously found that human fetal lung is a…”
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First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function by Piters, Elke, Culha, Cavit, Moester, Martiene, Van Bezooijen, Rutger, Adriaensen, Dirk, Mueller, Thomas, Weidauer, Stella, Jennes, Karen, de Freitas, Fenna, Löwik, Clemens, Timmermans, Jean-Pierre, Van Hul, Wim, Papapoulos, Socrates

“…Sclerosteosis is a rare bone dysplasia characterized by greatly increased bone mass, especially of the long bones and the skull. Patients are tall, show facial…”
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A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists by Chan, Alan, van Bezooijen, Rutger L, Löwik, Clemens W G M

“…The need to develop novel drugs that stimulate bone formation and thereby elevate bone mass (anabolics), as opposed to preventing bone loss (anti-resorptives),…”
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Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34 + cells in NOD/SCID mice by Noort, Willy A, Kruisselbrink, Alwine B, in't Anker, Pieternella S, Kruger, Marjolein, van Bezooijen, Rutger L, de Paus, Roelf A, Heemskerk, Mirjam H.M, Löwik, Clemens W.G.M, Falkenburg, J.H.Frederik, Willemze, Roel, Fibbe, Willem E

“…Mesenchymal stem cells (MSC) have been implicated as playing an important role in hematopoietic stem cell engraftment. We identified and characterized a new…”
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