Search Results - "van Berkel, S."

Staudinger Ligation as a Method for Bioconjugation by van Berkel, Sander S, van Eldijk, Mark B, van Hest, Jan C M

“…In 1919 the German chemist Hermann Staudinger was the first to describe the reaction between an azide and a phosphine. It was not until recently, however, that…”
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Higher-order multicomponent reactions: beyond four reactants by Brauch, Sebastian, van Berkel, Sander S, Westermann, Bernhard

“…Multicomponent reactions (MCRs) are by far the most successful class of reactions leading to high structural diversity and molecular complexity through a…”
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Traceless Tosylhydrazone-Based Triazole Formation: A Metal-Free Alternative to Strain-Promoted Azide-Alkyne Cycloaddition by van Berkel, Sander S., Brauch, Sebastian, Gabriel, Lars, Henze, Michael, Stark, Sebastian, Vasilev, Dimitar, Wessjohann, Ludger A., Abbas, Muhammad, Westermann, Bernhard

“…Triple‐T trick! Traceless tosylhydrazone‐based triazole formation is readily achieved by reacting primary amines with functional α,α‐dichlorotosylhydrozones…”
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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N‑Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates by van Geel, Remon, Wijdeven, Marloes A, Heesbeen, Ryan, Verkade, Jorge M. M, Wasiel, Anna A, van Berkel, Sander S, van Delft, Floris L

“…A robust, generally applicable, nongenetic technology is presented to convert monoclonal antibodies into stable and homogeneous ADCs. Starting from a native…”
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Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide-alkyne cycloaddition by Lima, Carolina G S, Ali, Akbar, van Berkel, Sander S, Westermann, Bernhard, Paixão, Márcio W

“…Metal-free 1,3-dipolar cycloaddition reactions have proven to be a powerful tool for the assembly of key heterocycles, in particular diversely functionalized…”
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Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition by Debets, Marjoke F, van Berkel, Sander S, Schoffelen, Sanne, Rutjes, Floris P J T, van Hest, Jan C M, van Delft, Floris L

“…A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent…”
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Recent Advances in Asymmetric Isocyanide-Based Multicomponent Reactions by van Berkel, Sander S., Bögels, Berry G. M., Wijdeven, Marloes A., Westermann, Bernhard, Rutjes, Floris P. J. T.

“…Isocyanide‐based multicomponent reactions (IMCRs) can be considered one of the breakthrough reaction classes of the last century. Moreover, asymmetric IMCRs…”
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Enantiodivergent Organocascade Reactions by Westermann, Bernhard, Ayaz, Muhammad, van Berkel, Sander S

“…Synchronizing organocatalysis! By targeting structural and stereochemical complexity with organocascade reactions, distinct catalysts can form molecular…”
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Feasibility of a multidisciplinary intervention to help cancer patients return to work by Leensen, M.C.J., Groeneveld, I.F., Rejda, T., Groenenboom, P., Berkel, S., Brandon, T., Boer, A.G.E.M., Frings‐Dresen, M.H.W.

“…This study evaluates feasibility of a multidisciplinary intervention combining occupational counselling with physical exercise to enhance cancer patients’…”
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Enzymatic glycan remodeling-metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering by Wijdeven, Marloes A., van Geel, Remon, Hoogenboom, Jorin H., Verkade, Jorge M. M., Janssen, Brian M. G., Hurkmans, Inge, de Bever, Laureen, van Berkel, Sander S., van Delft, Floris L.

“…Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Inspired by the trend to further improve their therapeutic…”
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Copper-Free Clickable Coatings by Canalle, Luiz A., van Berkel, Sander S., de Haan, Laurens T., van Hest, Jan C. M.

“…The copper‐catalyzed azide–alkyne 1,3‐dipolar cycloaddition (CuAAC) is extensively used for the functionalization of well‐defined polymeric materials. However,…”
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Metal-Free Triazole Formation as a Tool for Bioconjugation by van Berkel, Sander S, Dirks, A. (Ton) J, Debets, Marjoke F, van Delft, Floris L, Cornelissen, Jeroen J.L.M, Nolte, Roeland J.M, Rutjes, Floris P.J.T

“…Who needs copper? There is a strong demand for ligation reactions that proceed spontaneously, selectively, and under physiological conditions. To meet these…”
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Fluorogenic Peptide-Based Substrates for Monitoring Thrombin Activity by van Berkel, Sander S., van der Lee, Bas, van Delft, Floris L., Wagenvoord, Rob, Hemker, H. Coenraad, Rutjes, Floris P. J. T.

“…The synthesis of a series of peptides containing C‐terminal 7‐amino‐4‐methylcoumarin (AMC) for use in the thrombin generation test (TGT) is described. The lead…”
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Single-Step Azide Introduction in Proteins via an Aqueous Diazo Transfer by van Dongen, Stijn F. M, Teeuwen, Rosalie L. M, Nallani, Madhavan, van Berkel, Sander S, Cornelissen, Jeroen J. L. M, Nolte, Roeland J. M, van Hest, Jan C. M

“…The controlled introduction of azides in proteins provides targetable handles for selective protein manipulation. We present here an efficient diazo transfer…”
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Enzymatic strategies for (near) clinical development of antibody-drug conjugates by van Berkel, Sander S., van Delft, Floris L.

“…Target-specific killing of tumor cells with antibody-drug conjugates (ADCs) is an elegant concept in the continued fight against cancer. However, despite more…”
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Application of Metal-Free Triazole Formation in the Synthesis of Cyclic RGD-DTPA Conjugates by van Berkel, Sander S., Dirks, A. (Ton) J., Meeuwissen, Silvie A., Pingen, Dennis L. L., Boerman, Otto C., Laverman, Peter, van Delft, Floris L., Cornelissen, Jeroen J. L. M., Rutjes, Floris P. J. T.

“…The tandem 1,3‐dipolar cycloaddition‐retro‐Diels–Alder (tandem crDA) reaction is presented as a versatile method for metal‐free chemoselective conjugation of a…”
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Multitechnique Approach to Reveal the Mechanism of Copper(II)-Catalyzed Arylation Reactions by Tromp, Moniek, van Strijdonck, Gino P. F, van Berkel, Sander S, van den Hoogenband, Adri, Feiters, Martinus C, de Bruin, Bas, Fiddy, Steven G, van der Eerden, Ad M. J, van Bokhoven, Jeroen A, van Leeuwen, Piet W. N. M, Koningsberger, Diederik C

“…Multiple in situ and time-resolved spectroscopic techniques (EDXAFS, UV−vis, EPR, and NMR), with a focus on simultaneously acquired EDXAFS and time-resolved…”
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Influence of the molecular weight on mechanical behavior and associated strain-induced structural evolution of Poly(ethylene 2,5-furandicarboxylate) upon biaxial stretching by Stoclet, G., Xu, S., Gaucher, V., Tahon, J.F., van Berkel, S., Arias, A., Rogeret, C., Nourichard, R., de Vos, S.

“…The mechanical behavior of Poly(ethylene 2,5-furandicarboxylate) upon biaxial stretching and the associated strain-induced structural evolution is studied in…”
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A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates by Verkade, Jorge, Wijdeven, Marloes, Van Geel, Remon, Janssen, Brian, Van Berkel, Sander, Van Delft, Floris

“…Despite tremendous efforts in the field of targeted cancer therapy with antibody–drug conjugates (ADCs), attrition rates have been high. Historically, the…”
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Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction by Dirks, A J Ton, van Berkel, Sander S, Hatzakis, Nikos S, Opsteen, Joost A, van Delft, Floris L, Cornelissen, Jeroen J L M, Rowan, Alan E, van Hest, Jan C M, Rutjes, Floris P J T, Nolte, Roeland J M

“…Biohybrid amphiphiles have been prepared from terminal azide functionalised polystyrene and an alkyne functionalised peptide or protein via a Cu(I) catalysed…”
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