Search Results - "van Berkel, L A"

Human Lactoferrin and Peptides Derived from Its N Terminus Are Highly Effective against Infections with Antibiotic-Resistant Bacteria by NIBBERING, P. H, RAVENSBERGEN, E, WELLING, M. M, VAN BERKEL, L. A, VAN BERKEL, P. H. C, PAUWELS, E. K. J, NUIJENS, J. H

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IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4+ T cells: relevance to inflammatory bowel disease by Veenbergen, S., Li, P., Raatgeep, H. C., Lindenbergh-Kortleve, D. J., Simons-Oosterhuis, Y., Farrel, A., Costes, L. M. M., Joosse, M. E., van Berkel, L. A., de Ruiter, L. F., van Leeuwen, M. A., Winter, D., Holland, S. M., Freeman, A. F., Wakabayashi, Y., Zhu, J., de Ridder, L., Driessen, G. J., Escher, J. C., Leonard, W. J., Samsom, J. N.

“…Uncontrolled interferon γ (IFNγ)-mediated T-cell responses to commensal microbiota are a driver of inflammatory bowel disease (IBD). Interleukin-10 (IL-10) is…”
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New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells by Hauet‐Broere, F., Unger, W. W. J., Berkel, L. A., Garssen, J., Hoijer, M. A., Kraal, G., Samsom, J. N.

“…Although as pretreatment oral tolerance is a potent means to achieve systemic suppression, its application in ongoing disease is controversial. Here we propose…”
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IL-10 signaling prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine by Costes, L. M. M., Lindenbergh-Kortleve, D. J., van Berkel, L. A., Veenbergen, S., Raatgeep, H. (R). C., Simons-Oosterhuis, Y., van Haaften, D. H., Karrich, J. J., Escher, J. C., Groeneweg, M., Clausen, B. E., Cupedo, T., Samsom, J. N.

“…Summary Breach of tolerance to gluten leads to the chronic small intestinal enteropathy celiac disease. A key event in celiac disease development is…”
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Colonic tolerance develops in the iliac lymph nodes and can be established independent of CD103+ dendritic cells by Veenbergen, S, van Berkel, L A, du Pré, M F, He, J, Karrich, J J, Costes, L M M, Luk, F, Simons-Oosterhuis, Y, Raatgeep, H C, Cerovic, V, Cupedo, T, Mowat, A M, Kelsall, B L, Samsom, J N

“…Tolerance to harmless exogenous antigens is the default immune response in the gastrointestinal tract. Although extensive studies have demonstrated the…”
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Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance by van Leeuwen, M A, Costes, L M M, van Berkel, L A, Simons-Oosterhuis, Y, du Pré, M F, Kozijn, A E, Raatgeep, H C, Lindenbergh-Kortleve, D J, van Rooijen, N, Koning, F, Samsom, J N

“…Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance…”
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Monitoring and Modulation of Inducible Foxp3 + Regulatory T-Cell Differentiation in the Lymph Nodes Draining the Small Intestine and Colon by Veenbergen, S, van Berkel, L A, du Pré, M F, Kozijn, A E, Samsom, Janneke N

“…The mucosa-draining lymphoid tissue favors differentiation of inducible Foxp3 regulatory T cells. Adoptive transfer of T-cell receptor (TCR) transgenic (Tg) T…”
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Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4 by Broere, F, du Pré, M F, van Berkel, L A, Garssen, J, Schmidt-Weber, C B, Lambrecht, B N, Hendriks, R W, Nieuwenhuis, E E S, Kraal, G, Samsom, J N

“…Oral intake of protein leads to tolerance through the induction of regulatory T cells (Tr cells) in mesenteric lymph nodes (MLNs). Here we show that the…”
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P063 Expression of the coinhibitory receptor TIGIT on memory CD4+ T cells is induced by TCR ligation and retinoic acid co-stimulation and is elicited during microbial colonization of the intestine by Barendregt, D, Joosse, M E, van Berkel, L A, van Schoonhoven, A, Samsom, J N

“…Abstract Background The coinhibitory receptor T cell immunoglobulin and ITIM domain (TIGIT) is widely expressed by immune cells, including CD4+ T cells…”
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DOP32 CD226+TIGITneg expression identifies pathogenic inflammatory CD4+ memory T cells in severe Crohn’s Disease patients, opening up opportunities for patient-tailored treatment strategies by Barendregt, D, Heredia, M, Tindemans, I, Klomberg, R C W, Calado, B, Hulleman-van Haaften, D H, Tuk, B, van Berkel, L A, Escher, J C, de Ridder, L, Samsom, J N

“…Abstract Background CD4+ memory T cells (Tmem) drive chronicity of inflammation in Crohn’s disease (CD) and ulcerative colitis (UC). Treatments specifically…”
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P061 Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease course by Heredia, M, Charrout, M, Klomberg, R C W, Aardoom, M A, Jongsma, M M E, Kemos, P, van Haaften, D H, Tuk, B, van Berkel, L A, Bley Folly, B, Mahfouz, A, Reinders, M J T, Ruemmele, F, Croft, N, Escher, J C, de Ridder, L, Samsom, J N

“…Abstract Background Chronicity of inflammatory bowel disease (IBD) is driven by reactivation of inflammatory memory CD4+ T helper (Th) cells which activate an…”
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OP39 The effect of phenotype and genotype on the plasma proteome in patients with Inflammatory Bowel Disease by Bourgonje, A R, Hu, S, Spekhorst, L M, Zhernakova, D V, Vich Vila, A, Li, Y, Voskuil, M D, van Berkel, L A, Bley Folly, B, Charrout, M, Mahfouz, A, Reinders, M J T, van Heck, J I P, Joosten, L A B, Visschedijk, M C, van Dullemen, H M, Faber, K N, Samsom, J N, Festen, E A M, Dijkstra, G, Weersma, R K

“…Abstract Background Protein profiling in patients with inflammatory bowel diseases (IBD) for diagnostic and therapeutic purposes is underexplored. Assessment…”
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Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-[gamma]-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance by Van Leeuwen, M A, Costes, L M M, Van Berkel, L A, Simons-oosterhuis, Y, Du Pré, M F, Kozijn, A E, Raatgeep, H C, Lindenbergh-kortleve, D J, Van Rooijen, N, Koning, F, Samsom, J N

“…Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance…”
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P110 TIGIT expression identifies circulating CD38+ effector T cells with immune regulatory properties whose frequencies at diagnosis predict disease course of paediatric IBD patients by Joosse, M, Joosse, M, Menckeberg, C, de Ruiter, L F, Raatgeep, H, van Berkel, L A, Simons-Oosterhuis, Y, Hendriks, R W, Hoogenboezem, R M, Cupedo, T, de Ridder, L, Escher, J, Veenbergen, S, Samsom, J N

“…Abstract Background Disease heterogeneity hampers achieving long-term disease remission in inflammatory bowel disease (IBD). Monitoring ongoing…”
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Early Events in Peripheral Regulatory T Cell Induction via the Nasal Mucosa by Unger, Wendy W. J, Hauet-Broere, Femke, Jansen, Wendy, van Berkel, Lisette A, Kraal, Georg, Samsom, Janneke N

“…Nasal application of soluble Ags leads to Ag-specific suppression of systemic immune responses. This tolerance can be transferred to naive mice by CD4(+)…”
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Original article: New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells by Hauet-Broere, F, Unger, W W J, van Berkel, L A, Garssen, J, Hoijer, M A, Kraal, G, Samsom, J N

“…Although as pretreatment oral tolerance is a potent means to achieve systemic suppression, its application in ongoing disease is controversial. Here we propose…”
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Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells by Samsom, Janneke N, van Berkel, Lisette A, van Helvoort, Joop M L M, Unger, Wendy W J, Jansen, Wendy, Thepen, Theo, Mebius, Reina E, Verbeek, Sjef S, Kraal, Georg

“…Mucosal tolerance prevents the body from eliciting productive immune responses against harmless Ags that enter the body via the mucosae, and is mediated by the…”
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