Search Results - "van Bergen En Henegouwen, P M P"

Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects by van de Water, Jeroen A. J. M, Bagci-Onder, Tugba, Agarwal, Aayush S, Wakimoto, Hiroaki, Roovers, Rob C, Zhu, Yanni, Kasmieh, Randa, Bhere, Deepak, Van Bergen en Henegouwen, Paul M. P, Shah, Khalid

“…The deregulation of the epidermal growth factor receptor (EGFR) has a significant role in the progression of tumors. Despite the development of a number of…”
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Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH by Emmerson, Chris D, van der Vlist, Els J, Braam, Myrthe R, Vanlandschoot, Peter, Merchiers, Pascal, de Haard, Hans J W, Verrips, C Theo, van Bergen en Henegouwen, Paul M P, Dolk, Edward

“…The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia…”
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The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers by Zanetti-Domingues, Laura C., Korovesis, Dimitrios, Needham, Sarah R., Tynan, Christopher J., Sagawa, Shiori, Roberts, Selene K., Kuzmanic, Antonija, Ortiz-Zapater, Elena, Jain, Purvi, Roovers, Rob C., Lajevardipour, Alireza, van Bergen en Henegouwen, Paul M. P., Santis, George, Clayton, Andrew H. A., Clarke, David T., Gervasio, Francesco L., Shan, Yibing, Shaw, David E., Rolfe, Daniel J., Parker, Peter J., Martin-Fernandez, Marisa L.

“…Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments…”
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Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor by Zaiss, Dietmar M.W., van Loosdregt, Jorg, Gorlani, Andrea, Bekker, Cornelis P.J., Gröne, Andrea, Sibilia, Maria, van Bergen en Henegouwen, Paul M.P., Roovers, Rob C., Coffer, Paul J., Sijts, Alice J.A.M.

“…Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here…”
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Nanobodies and Nanocrystals: Highly Sensitive Quantum Dot-Based Homogeneous FRET Immunoassay for Serum-Based EGFR Detection by Wegner, K. David, Lindén, Stina, Jin, Zongwen, Jennings, Travis L., Khoulati, Rachid el, van Bergen en Henegouwen, Paul M. P., Hildebrandt, Niko

“…Semiconductor quantum dot nanocrystals (QDs) for optical biosensing applications often contain thick polyethylene glycol (PEG)‐based coatings in order to…”
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A small protein probe for correlated microscopy of endogenous proteins by de Beer, Marit A., Kuipers, Jeroen, van Bergen en Henegouwen, Paul M. P., Giepmans, Ben N. G.

“…Probes are essential to visualize proteins in their cellular environment, both using light microscopy as well as electron microscopy (EM). Correlated light…”
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Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors by Xenaki, Katerina T, Oliveira, Sabrina, van Bergen En Henegouwen, Paul M P

“…The use of antibody-based therapeutics has proven very promising for clinical applications in cancer patients, with multiple examples of antibodies and…”
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EGF induces coalescence of different lipid rafts by Hofman, Erik G, Ruonala, Mika O, Bader, Arjen N, van den Heuvel, Dave, Voortman, Jarno, Roovers, Rob C, Verkleij, Arie J, Gerritsen, Hans C, van Bergen en Henegouwen, Paul M.P

“…The suggestion that microdomains may function as signaling platforms arose from the presence of growth factor receptors, such as the EGFR, in biochemically…”
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Single Domain Antibodies as Carriers for Intracellular Drug Delivery: A Proof of Principle Study by Pronk, Sebas D., Schooten, Erik, Heinen, Jurgen, Helfrich, Esra, Oliveira, Sabrina, van Bergen en Henegouwen, Paul M. P.

“…Antibody-drug conjugates (ADCs) are currently used for the targeted delivery of drugs to diseased cells, but intracellular drug delivery and therefore efficacy…”
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Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody by Zeronian, Matthieu R, Doulkeridou, Sofia, van Bergen En Henegouwen, Paul M P, Janssen, Bert J C

“…The epidermal growth factor receptor (EGFR) is involved in various developmental processes, and alterations of its extracellular segment are associated with…”
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A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR) by Su, Ruifang, Wu, Yu‐Tang, Doulkeridou, Sofia, Qiu, Xue, Sørensen, Thomas Just, Susumu, Kimihiro, Medintz, Igor L., Bergen en Henegouwen, Paul M. P., Hildebrandt, Niko

“…Biosensing approaches that combine small, engineered antibodies (nanobodies) with nanoparticles are often complicated. Here, we show that nanobodies with…”
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Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization by Kijanka, Marta M., van Brussel, Aram S. A., van der Wall, Elsken, Mali, Willem P. T. M., van Diest, Paul J., van Bergen en Henegouwen, Paul M. P., Oliveira, Sabrina

“…Background Optical molecular imaging is an emerging novel technology with applications in the diagnosis of cancer and assistance in image-guided surgery. A…”
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Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains by Schmitz, Karl R., Bagchi, Atrish, Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Ferguson, Kathryn M.

“…The epidermal growth factor receptor (EGFR) is implicated in human cancers and is the target of several classes of therapeutic agents, including antibody-based…”
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Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9 by Neviani, Viviana, Deventer, Sjoerd, Wörner, Tobias P., Xenaki, Katerina T., Waterbeemd, Michiel, Rodenburg, Remco N. P., Wortel, Inge M. N., Kuiper, Jeroen K., Huisman, Sofie, Granneman, Joke, Bergen en Henegouwen, Paul M. P., Heck, Albert J. R., Spriel, Annemiek B., Gros, Piet

“…Lipidation of transmembrane proteins regulates many cellular activities, including signal transduction, cell–cell communication, and membrane trafficking…”
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ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy by Harwood, Seandean Lykke, Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Compte, Marta, Hernández-Pérez, Sara, Merino, Nekane, Bonet, Jaume, Navarro, Rocio, Van Bergen en Henegouwen, Paul M. P., Lykkemark, Simon, Mikkelsen, Kasper, Mølgaard, Kasper, Jabs, Frederic, Sanz, Laura, Blanco, Francisco J., Roda-Navarro, Pedro, Alvarez-Vallina, Luis

“…The redirection of T cell activity using bispecific antibodies is one of the most promising cancer immunotherapy approaches currently in development, but it is…”
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The munc13-4–rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane by Elstak, Edo D., Neeft, Maaike, Nehme, Nadine T., Voortman, Jarno, Cheung, Marc, Goodarzifard, Monireh, Gerritsen, Hans C., van Bergen en Henegouwen, Paul M.P., Callebaut, Isabelle, de Saint Basile, Geneviève, van der Sluijs, Peter

“…Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules from secretory lysosomes. Loss of munc13-4 function inhibits…”
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A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells by de Bruin, Renée C. G., Veluchamy, John P., Lougheed, Sinéad M., Schneiders, Famke L., Lopez-Lastra, Silvia, Lameris, Roeland, Stam, Anita G., Sebestyen, Zsolt, Kuball, Jürgen, Molthoff, Carla F. M., Hooijberg, Erik, Roovers, Rob C., Santo, James P. Di, van Bergen en Henegouwen, Paul M. P., Verheul, Henk M. W., de Gruijl, Tanja D., van der Vliet, Hans J.

“…Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and…”
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Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast by van Brussel, Aram S. A., Adams, Arthur, Vermeulen, Jeroen F., Oliveira, Sabrina, van der Wall, Elsken, Mali, Willem P. Th. M., van Diest, Paul. J., van Bergen en Henegouwen, Paul M. P.

“…Ductal carcinoma in situ (DCIS) of the breast is difficult to remove completely during surgery as it is not palpable and can therefore require re-excision…”
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Homo-FRET Imaging as a Tool to Quantify Protein and Lipid Clustering by Bader, Arjen N., Hoetzl, Sandra, Hofman, Erik G., Voortman, Jarno, van Bergen en Henegouwen, Paul M. P., van Meer, Gerrit, Gerritsen, Hans C.

“…Homo‐FRET, Förster resonance energy transfer between identical fluorophores, can be conveniently measured by observing its effect on the fluorescence…”
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Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment by van der Meel, Roy, Oliveira, Sabrina, Altintas, Isil, Haselberg, Rob, van der Veeken, Joris, Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Storm, Gert, Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J.

“…The epidermal growth factor receptor (EGFR) is a validated target for anti-cancer therapy and several EGFR inhibitors are used in the clinic. Over the years,…”
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