Search Results - "van Beers, Miranda M. C."

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice by van Beers, Miranda M. C., Sauerborn, Melody, Gilli, Francesca, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim

“…ABSTRACT Purpose To study the effect of oxidation on the structure of recombinant human interferon beta-1a (rhIFNβ-1a) and its immunogenicity in wild-type and…”
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Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice by van Beers, Miranda M. C., Sauerborn, Melody, Gilli, Francesca, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim

“…ABSTRACT Purpose To study the influence of protein aggregation on the immunogenicity of recombinant human interferon beta (rhIFNβ) in wild-type mice and…”
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Allergen Ara h 1 Occurs in Peanuts as a Large Oligomer Rather Than as a Trimer by van Boxtel, Evelien L, van Beers, Miranda M. C, Koppelman, Stef J, van den Broek, Lambertus A. M, Gruppen, Harry

“…Ara h 1, a major peanut allergen, is known as a stable trimeric protein. Nevertheless, upon purification of native Ara h 1 from peanuts using only size…”
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Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene by Van Beers, Miranda M C, Gilli, Francesca, Schellekens, Huub, Randolph, Theodore W, Jiskoot, Wim

“…Aggregates play a major role in the immunogenicity of recombinant human interferon beta (rhIFNβ), a protein used to treat multiple sclerosis. A possible cause…”
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On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis by van Beers, Miranda M C, Jiskoot, Wim, Schellekens, Huub

“…Like many other therapeutic proteins, recombinant human interferon beta (rhIFN-β) elicits undesirable immune responses. rhIFN-β-treated multiple sclerosis…”
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Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta by van Beers, Miranda M.C., Sauerborn, Melody, Gilli, Francesca, Hermeling, Suzanne, Brinks, Vera, Schellekens, Huub, Jiskoot, Wim

“…To date, the therapeutic efficacy of recombinant human proteins is limited by their potential to break B cell tolerance in patients. The formation of…”
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Antibody Response Against Betaferon® in Immune Tolerant Mice: Involvement of Marginal Zone B-cells and CD4+ T-cells and Apparent Lack of Immunological Memory by Sauerborn, Melody, van Beers, Miranda M. C., Jiskoot, Wim, Kijanka, Grzegorz M., Boon, Louis, Schellekens, Huub, Brinks, Vera

“…Purpose The immunological processes underlying immunogenicity of recombinant human therapeutics are poorly understood. Using an immune tolerant mouse model we…”
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Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins by van Beers, Miranda M. C., Bardor, Muriel

“…Adverse immune responses severely hamper the success of biopharmaceutical therapies. Possible clinical consequences include anaphylaxis, reduced drug half‐life…”
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Micro-Flow Imaging as a quantitative tool to assess size and agglomeration of PLGA microparticles by van Beers, Miranda M.C., Slooten, Cees, Meulenaar, Jelte, Sediq, Ahmad S., Verrijk, Ruud, Jiskoot, Wim

“…[Display omitted] The purpose of this study was to explore the potential of flow imaging microscopy to measure particle size and agglomeration of…”
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A Flow Imaging Microscopy-Based Method Using Mass-to-Volume Ratio to Derive the Porosity of PLGA Microparticles by Sediq, Ahmad S, Waasdorp, Stephan K D, Nejadnik, M Reza, van Beers, Miranda M C, Meulenaar, Jelte, Verrijk, Ruud, Jiskoot, Wim

“…The release of drugs from poly(lactic-co-glycolic acid) (PLGA) microparticles depends to a large extent on the porosity of the particles. Therefore, porosity…”
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