Search Results - "van Beelen, Astrid J"

Commensal Gram‐negative bacteria prime human dendritic cells for enhanced IL‐23 and IL‐27 expression and enhanced Th1 development by Smits, Hermelijn H., van Beelen, Astrid J., Hessle, Christina, Westland, Robert, de Jong, Esther, Soeteman, Eelco, Wold, Agnes, Wierenga, Eddy A., Kapsenberg, Martien L.

“…Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on microbial information they encounter in peripheral tissues, they…”
Get full text

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells by van Beelen, Astrid J., Zelinkova, Zuzana, Taanman-Kueter, Esther W., Muller, Femke J., Hommes, Daniel W., Zaat, Sebastian A.J., Kapsenberg, Martien L., de Jong, Esther C.

“…How the development of antibacterial T helper 17 (Th17) cells is selectively promoted by antigen-presenting dendritic cells (DCs) is unclear. We showed that…”
Get full text

Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naïve CD8+ T cells by de Groot, Rosa, van Beelen, Astrid J, Bakdash, Ghaith, Taanman-Kueter, Esther W M, de Jong, Esther C, Kapsenberg, Martien L

“…Upon viral stimulation, human BDCA1+ dendritic cells produce IL‐12 to promote inflammatory cytokines, and IL‐27 to enhance cytotoxic responses in developing…”
Get full text

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells by Unger, Wendy W.J., van Beelen, Astrid J., Bruijns, Sven C., Joshi, Medha, Fehres, Cynthia M., van Bloois, Louis, Verstege, Marleen I., Ambrosini, Martino, Kalay, Hakan, Nazmi, Kamran, Bolscher, Jan G., Hooijberg, Erik, de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette

“…Cancer immunotherapy requires potent tumor-specific CD8+ and CD4+ T-cell responses, initiated by dendritic cells (DCs). Tumor antigens can be specifically…”
Get full text

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T‐cell cross‐priming by Fehres, Cynthia M., Bruijns, Sven C. M., Beelen, Astrid J., Kalay, Hakan, Ambrosini, Martino, Hooijberg, Erik, Unger, Wendy W. J., Gruijl, Tanja D., Kooyk, Yvette

“…Toll‐like receptor (TLR) ligands are attractive candidate adjuvants for therapeutic cancer vaccines, since TLR signaling stimulates and tunes both humoral and…”
Get full text

In situ Delivery of Antigen to DC-SIGN+CD14+ Dermal Dendritic Cells Results in Enhanced CD8+ T-Cell Responses by Fehres, Cynthia M., van Beelen, Astrid J., Bruijns, Sven C.M., Ambrosini, Martino, Kalay, Hakan, Bloois, Louis van, Unger, Wendy W.J., Garcia-Vallejo, Juan J., Storm, Gert, de Gruijl, Tanja D., Kooyk, Yvette van

“…CD14+ dendritic cells (DCs) present in the dermis of human skin represent a large subset of dermal DCs (dDCs) that are considered macrophage-like cells with…”
Get full text

Interleukin-17 in inflammatory skin disorders by van Beelen, Astrid J, Teunissen, Marcel BM, Kapsenberg, Martien L, de Jong, Esther C

“…PURPOSE OF REVIEWRecently, a novel and unique subset of interleukin (IL)-17-producing CD4 T helper (Th17) cells, distinct from Th1 and Th2 cells, was…”
Get full text

New roles for CD14 and IL‐β linking inflammatory dendritic cells to IL‐17 production in memory CD4+ T cells by Ilarregui, Juan M, Beelen, Astrid J, Fehres, Cynthia M, Bruijns, Sven C M, García‐Vallejo, Juan J, Kooyk, Yvette

“…Interleukin (IL)‐1β has proven to be crucial in the differentiation of human and mouse Th17 cells. Although it has become evident that IL‐1β has potent…”
Get full text

CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation by de Wit, Jelle, Souwer, Yuri, van Beelen, Astrid J., de Groot, Rosa, Muller, Femke J.M., Klaasse Bos, Hanny, Jorritsma, Tineke, Kapsenberg, Martien L., de Jong, Esther C., van Ham, S. Marieke

“…IL-17–producing CD4+ T helper (Th17) cells are important for immunity against extracellular pathogens and in autoimmune diseases. The factors that drive Th17…”
Get full text

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations by Joshi, Medha D., Unger, Wendy W.J., van Beelen, Astrid J., Bruijns, Sven C., Litjens, Manja, van Bloois, Louis, Kalay, Hakan, van Kooyk, Yvette, Storm, Gert

“…Dendritic cells (DCs) are key antigen presenting cells that have the unique ability to present antigens on MHC molecules, which can lead to either priming or…”
Get full text

Muramyl dipeptide–induced differential gene expression in NOD2 mutant and wild‐type crohn's disease patient–derived dendritic cells by Zelinkova, Zuzana, van Beelen, Astrid J., de Kort, Floor, Moerland, Perry D., van Themaat, Emiel Ver Loren, Velde, Anje A.te, van Deventer, Sander J., de Jong, Esther C., Hommes, Daniel W.

“…Background: Mutations in the gene encoding the nucleotide‐binding oligomerization domain 2 (NOD2) protein are associated with Crohn's disease (CD), but the…”
Get full text

New roles for CD14 and IL- beta linking inflammatory dendritic cells to IL-17 production in memory CD4 super(+) T cells by Ilarregui, Juan M, van Beelen, Astrid J, Fehres, Cynthia M, Bruijns, Sven C M, Garcia-Vallejo, Juan J, van Kooyk, Yvette

“…Interleukin (IL)-1 beta has proven to be crucial in the differentiation of human and mouse Th17 cells. Although it has become evident that IL-1 beta has potent…”
Get full text

New roles for CD14 and IL-[beta] linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cells by Ilarregui, Juan M, Van Beelen, Astrid J, Fehres, Cynthia M, Bruijns, Sven C M, García-vallejo, Juan J, Van Kooyk, Yvette

“…Interleukin (IL)-1β has proven to be crucial in the differentiation of human and mouse Th17 cells. Although it has become evident that IL-1β has potent…”
Get full text

In situ Delivery of Antigen to DC-SIGN super(+)CD14 super(+) Dermal Dendritic Cells Results in Enhanced CD8 super(+) T-Cell Responses by Fehres, Cynthia M, van Beelen, Astrid J, Bruijns, Sven C M, Ambrosini, Martino, Kalay, Hakan, Bloois, Louis van, Unger, Wendy W J, Garcia-Vallejo, Juan J, Storm, Gert, de Gruijl, Tanja D, Kooyk, Yvette van

“…CD14 super(+) dendritic cells (DCs) present in the dermis of human skin represent a large subset of dermal DCs (dDCs) that are considered macrophage-like cells…”
Get full text

Activation of human macrophages by amyloid-beta is attenuated by astrocytes by Smits, H A, van Beelen, A J, de Vos, N M, Rijsmus, A, van der Bruggen, T, Verhoef, J, van Muiswinkel, F L, Nottet, H S

“…In Alzheimer's disease, neuritic amyloid-beta plaques along with surrounding activated microglia and astrocytes are thought to play an important role in the…”
Get full text

Activation of Human Macrophages by Amyloid-{{beta}} Is Attenuated by Astrocytes by Smits, Hessel A, van Beelen, Astrid J, de Vos, N. Machiel, Rijsmus, Annemarie, van der Bruggen, Tjomme, Verhoef, Jan, van Muiswinkel, Freek L, Nottet, Hans S. L. M

Get full text