Search Results - "van Beek, Josine"

Associations and recovery dynamics of the nasopharyngeal microbiota during influenza-like illness in the aging population by Shetty, Sudarshan A., van Beek, Josine, Bijvank, Elske, Groot, James, Kuiling, Sjoerd, Bosch, Thijs, van Baarle, Debbie, Fuentes, Susana

“…Influenza-like illness (ILI), a disease caused by respiratory pathogens including influenza virus, is a major health concern in older adults. There is little…”
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Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance by Rosendahl Huber, Sietske K, Luimstra, Jolien J, van Beek, Josine, Hoppes, Rieuwert, Jacobi, Ronald H J, Hendriks, Marion, Kapteijn, Kim, Ouwerkerk, Casper, Rodenko, Boris, Ovaa, Huib, de Jonge, Jørgen

“…T cells are essential players in the defense against infection. By targeting the MHC class I antigen-presenting pathway with peptide-based vaccines,…”
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Antibody and Local Cytokine Response to Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults by Yu, Xiao, Lakerveld, Anke J., Imholz, Sandra, Hendriks, Marion, ten Brink, Sofie C. A., Mulder, H. Lie, de Haan, Karen, Schepp, Rutger M., Luytjes, Willem, de Jong, Menno D., van Beek, Josine, van Kasteren, Puck B.

“…Respiratory syncytial virus (RSV) can cause severe morbidity and mortality in certain risk groups, especially infants and older adults. Currently no…”
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SARS-CoV-2-Specific Antibody Detection for Seroepidemiology: A Multiplex Analysis Approach Accounting for Accurate Seroprevalence by den Hartog, Gerco, Schepp, Rutger M, Kuijer, Marjan, GeurtsvanKessel, Corine, van Beek, Josine, Rots, Nynke, Koopmans, Marion P G, van der Klis, Fiona R M, van Binnendijk, Robert S

“…The COVID-19 pandemic necessitates better understanding of the kinetics of antibody production induced by infection with SARS-CoV-2. We aimed to develop a…”
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Pre‐vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination by Cevirgel, Alper, Shetty, Sudarshan A., Vos, Martijn, Nanlohy, Nening M., Beckers, Lisa, Bijvank, Elske, Rots, Nynke, Beek, Josine, Buisman, Anne‐Marie, Baarle, Debbie

“…Effective vaccine‐induced immune responses are particularly essential in older adults who face an increased risk of immunosenescence. However, the complexity…”
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Identification of aging‐associated immunotypes and immune stability as indicators of post‐vaccination immune activation by Cevirgel, Alper, Shetty, Sudarshan A., Vos, Martijn, Nanlohy, Nening M., Beckers, Lisa, Bijvank, Elske, Rots, Nynke, Beek, Josine, Buisman, Anne‐Marie, Baarle, Debbie

“…Immunosenescence describes immune dysfunction observed in older individuals. To identify individuals at‐risk for immune dysfunction, it is crucial to…”
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Delineating immune variation between adult and children COVID-19 cases and associations with disease severity by Cevirgel, Alper, Vos, Martijn, Holtrop, Anne Floor, Beckers, Lisa, Reukers, Daphne F. M., Meijer, Adam, Rots, Nynke, van Beek, Josine, van Baarle, Debbie, de Wit, Jelle

“…The SARS-CoV-2 pandemic has emphasized the need to explore how variations in the immune system relate to the severity of the disease. This study aimed to…”
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Regulatory KIR+RA+ T cells accumulate with age and are highly activated during viral respiratory disease by Pieren, Daan K. J., Smits, Noortje A. M., Hoeboer, Jeroen, Kandiah, Vinitha, Postel, Rimke J., Mariman, Rob, Beek, Josine, Baarle, Debbie, Wit, Jelle, Guichelaar, Teun

“…Severe respiratory viral infectious diseases such as influenza and COVID‐19 especially affect the older population. This is partly ascribed to diminished CD8+…”
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Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial by van der Heiden, Marieke, Shetty, Sudarshan, Bijvank, Elske, Beckers, Lisa, Cevirgel, Alper, van Sleen, Yannick, Tcherniaeva, Irina, Ollinger, Thierry, Burny, Wivine, van Binnendijk, Rob S., van Houten, Marianne A., Buisman, Anne-Marie, Rots, Nynke Y., van Beek, Josine, van Baarle, Debbie

“…Vaccine responsiveness is often reduced in older adults. Yet, our lack of understanding of low vaccine responsiveness hampers the development of effective…”
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Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013 by van Kasteren, Puck B, Gelderloos, Anne T, Nicolaie, Mioara Alina, den Hartog, Gerco, Vissers, Marloes, Luytjes, Willem, Rots, Nynke Y, van Beek, Josine

“…Abstract Respiratory pathogens can cause severe disease and even death, especially in the very young and very old. Studies investigating their prevalence often…”
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Carriage of Streptococcus pneumoniae in aged adults with influenza-like-illness by Krone, Cassandra L, Wyllie, Anne L, van Beek, Josine, Rots, Nynke Y, Oja, Anna E, Chu, Mei Ling J N, Bruin, Jacob P, Bogaert, Debby, Sanders, Elisabeth A M, Trzciński, Krzysztof

“…Incidence of pneumococcal disease is disproportionally high in infants and elderly. Nasopharyngeal colonisation by Streptococcus pneumoniae is considered a…”
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Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus by Westerhuis, Brenda, ten Hulscher, Hinke, Jacobi, Ronald, van Beek, Josine, Koopmans, Marion, Rimmelzwaan, Guus, Meijer, Adam, van Binnendijk, Rob

“…H7 avian influenza viruses represent a major public health concern, and worldwide outbreaks raise the risk of a potential pandemic. Understanding the memory B…”
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Co-Expression of TIGIT and Helios Marks Immunosenescent CD8 + T Cells During Aging by Pieren, Daan K J, Smits, Noortje A M, Postel, Rimke J, Kandiah, Vinitha, de Wit, Jelle, van Beek, Josine, van Baarle, Debbie, Guichelaar, Teun

“…Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as…”
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Children and Adults With Mild COVID-19: Dynamics of the Memory T Cell Response up to 10 Months by Kaaijk, Patricia, Pimentel, Verónica Olivo, Emmelot, Maarten E, Poelen, Martien, Cevirgel, Alper, Schepp, Rutger M, den Hartog, Gerco, Reukers, Daphne F M, Beckers, Lisa, van Beek, Josine, van Els, Cécile A C M, Meijer, Adam, Rots, Nynke Y, de Wit, Jelle

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to considerable morbidity/mortality worldwide, but most infections, especially among…”
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Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection by Van de Garde, Martijn D. B., Miranda-Bedate, Alberto, Nanlohy, Nening M., Jacobi, Ronald H. J., Meijer, Adam, Reukers, Daphne F. M., Van Beek, Josine, Van Els, Cecile A. C. M., Van Baarle, Debbie, Rots, Nynke Y., De Wit, Jelle, Pinelli, Elena

“…Background To date, it is still not clear why during the COVID-19 pandemic children generally developed no or milder symptoms compared to adults. As innate…”
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Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus by Westerhuis, Brenda, ten Hulscher, Hinke, Jacobi, Ronald, van Beek, Josine, Koopmans, Marion, Rimmelzwaan, Guus, Meijer, Adam, van Binnendijk, Rob

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach by van Tol, Sophie, Mögling, Ramona, Li, Wentao, Godeke, Gert-Jan, Swart, Arno, Bergmans, Barbara, Brandenburg, Afke, Kremer, Kristin, Murk, Jean-Luc, van Beek, Josine, Wintermans, Bas, Reimerink, Johan, Bosch, Berend-Jan, Reusken, Chantal

“…Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical…”
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Frailty is related to serum inflammageing markers: results from the VITAL study by van Sleen, Yannick, Shetty, Sudarshan A, van der Heiden, Marieke, Venema, Milou C. A, Gutiérrez-Melo, Nicolas, Toonen, Erik J. M, van Beek, Josine, Buisman, Anne-Marie, van Baarle, Debbie, Sauce, Delphine

“…Abstract Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score…”
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Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status by Brummelman, Jolanda, Suárez-Hernández, Sara, de Rond, Lia, Bogaard-van Maurik, Marjan, Molenaar, Petra, van Wijlen, Emma, Oomen, Debbie, Beckers, Lisa, Rots, Nynke Y, van Beek, Josine, Nicolaie, Mioara A, van Els, Cécile A C M, Boer, Mardi C, Kaaijk, Patricia, Buisman, Anne-Marie, de Wit, Jelle

“…Accumulating evidence indicates the importance of T cell immunity in vaccination-induced protection against severe COVID-19 disease, especially against…”
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Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults by van den Berg, Sara P H, Wong, Albert, Hendriks, Marion, Jacobi, Ronald H J, van Baarle, Debbie, van Beek, Josine

“…Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger…”
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