Search Results - "van Beek, Johannes H M"

The Influence of Semantically Related and Unrelated Text Cues on the Intelligibility of Sentences in Noise by Zekveld, Adriana A, Rudner, Mary, Johnsrude, Ingrid S, Festen, Joost M, van Beek, Johannes H. M, Rönnberg, Jerker

“…OBJECTIVES:In two experiments with different subject groups, we explored the relationship between semantic context and intelligibility by examining the…”
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Computational prediction of changes in brain metabolic fluxes during Parkinson's disease from mRNA expression by Supandi, Farahaniza, van Beek, Johannes H G M

“…Parkinson's disease is a widespread neurodegenerative disorder which affects brain metabolism. Although changes in gene expression during disease are often…”
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Using bioconductor package BiGGR for metabolic flux estimation based on gene expression changes in brain by Gavai, Anand K, Supandi, Farahaniza, Hettling, Hannes, Murrell, Paul, Leunissen, Jack A M, van Beek, Johannes H G M

“…Predicting the distribution of metabolic fluxes in biochemical networks is of major interest in systems biology. Several databases provide metabolic…”
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The Association Between Hearing Status and Psychosocial Health Before the Age of 70 Years: Results From an Internet-Based National Survey on Hearing by Nachtegaal, Janneke, Smit, Jan H, Smits, Cas, Bezemer, Pieter D, van Beek, Johannes H. M, Festen, Joost M, Kramer, Sophia E

“…OBJECTIVE:There is a substantial lack of knowledge of the impact of reduced hearing on psychosocial functioning in adults younger than 70 yr. The aim of this…”
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Cohort profile: Netherlands Longitudinal Study on Hearing (NL-SH) by van Wier, Marieke F, Jansen, Lotte A, Goderie, Thadé, Stam, Mariska, Nachtegaal, Janneke, van Beek, Johannes H M, Lemke, Ulrike, Anema, Johannes R, Lissenberg-Witte, Birgit I, Smits, Cas, Kramer, Sophia E

“…PurposeThe Netherlands Longitudinal Study on Hearing (NL-SH) was set up to examine associations of hearing ability with psychosocial, work and health outcomes…”
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A community-driven global reconstruction of human metabolism by Thiele, Ines, Swainston, Neil, Fleming, Ronan M T, Hoppe, Andreas, Sahoo, Swagatika, Aurich, Maike K, Haraldsdottir, Hulda, Mo, Monica L, Rolfsson, Ottar, Stobbe, Miranda D, Thorleifsson, Stefan G, Agren, Rasmus, Bölling, Christian, Bordel, Sergio, Chavali, Arvind K, Dobson, Paul, Dunn, Warwick B, Endler, Lukas, Hala, David, Hucka, Michael, Hull, Duncan, Jameson, Daniel, Jamshidi, Neema, Jonsson, Jon J, Juty, Nick, Keating, Sarah, Nookaew, Intawat, Le Novère, Nicolas, Malys, Naglis, Mazein, Alexander, Papin, Jason A, Price, Nathan D, Selkov, Evgeni, Sigurdsson, Martin I, Simeonidis, Evangelos, Sonnenschein, Nikolaus, Smallbone, Kieran, Sorokin, Anatoly, van Beek, Johannes H G M, Weichart, Dieter, Goryanin, Igor, Nielsen, Jens, Westerhoff, Hans V, Kell, Douglas B, Mendes, Pedro, Palsson, Bernhard Ø

“…The metabolic modeling community has curated information from five models to create the most comprehensive model of human metabolism to date. Multiple models…”
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Adenine nucleotide-creatine-phosphate module in myocardial metabolic system explains fast phase of dynamic regulation of oxidative phosphorylation by van Beek, Johannes H G M

“…Computational models of a large metabolic system can be assembled from modules that represent a biological function emerging from interaction of a small subset…”
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A vision and strategy for the virtual physiological human in 2010 and beyond by Hunter, Peter, Coveney, Peter V., de Bono, Bernard, Diaz, Vanessa, Fenner, John, Frangi, Alejandro F., Harris, Peter, Hose, Rod, Kohl, Peter, Lawford, Pat, McCormack, Keith, Mendes, Miriam, Omholt, Stig, Quarteroni, Alfio, Skr, John, Tegner, Jesper, Randall Thomas, S., Tollis, Ioannis, Tsamardinos, Ioannis, van Beek, Johannes H. G. M., Viceconti, Marco

“…European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of…”
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Analyzing the functional properties of the creatine kinase system with multiscale 'sloppy' modeling by Hettling, Hannes, van Beek, Johannes H G M

“…In this study the function of the two isoforms of creatine kinase (CK; EC 2.7.3.2) in myocardium is investigated. The 'phosphocreatine shuttle' hypothesis…”
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Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: identification by oligonucleotide microarray by Reijnders, Christianne M A, van Essen, Huib W, van Rens, Birgitte T T M, van Beek, Johannes H G M, Ylstra, Bauke, Blankenstein, Marinus A, Lips, Paul, Bravenboer, Nathalie

“…Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors…”
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Electron Density Fingerprints (EDprints): Virtual Screening Using Assembled Information of Electron Density by Kooistra, Albert J, Binsl, Thomas W, van Beek, Johannes H. G. M, de Graaf, Chris, Heringa, Jaap

“…We have designed a method to encode properties related to the electron densities of molecules (calculated 1H and 13C NMR shifts and atomic partial charges) in…”
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Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy by Binsl, Thomas W., Alders, David J.C., Heringa, Jaap, Groeneveld, A.B. Johan, van Beek, Johannes H.G.M.

“…Motivation: Quantitative determination of metabolic fluxes in single tissue biopsies is difficult. We report a novel analysis approach and software package for…”
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Coordinated Behavior of Mitochondria in Both Space and Time: A Reactive Oxygen Species-Activated Wave of Mitochondrial Depolarization by Brady, Nathan R., Elmore, Steven P., van Beek, Johannes J.H.G.M., Krab, Klaas, Courtoy, Pierre J., Hue, Louis, Westerhoff, Hans V.

“…Reactive oxygen species (ROS) can trigger a transient burst of mitochondrial ROS production via ROS activation of the mitochondrial permeability transition…”
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A Novel Method to Measure Artificial Eye Motility by Mourits, Daphne L, Hartong, Dyonne T, van Beek, Johannes H M, Witte, Birgit I, Tan, H Stevie, Moll, Annette C

“…To measure objectively, reproducibly, and noninvasively artificial eye motility, a fundamental aspect in the (cosmetic) outcome of enucleation. A gaze- and…”
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Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance by van Beek, Johannes H. G. M., Kirkwood, Thomas B. L., Bassingthwaighte, James B.

“…Ageing and lifespan are strongly affected by metabolism. The maximal possible uptake of oxygen is not only a good predictor of performance in endurance sports,…”
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FluxSimulator : An R Package to Simulate Isotopomer Distributions in Metabolic Networks by Binsl, Thomas W., Mullen, Katharine M., Stokkum, Ivo H. M. van, Heringa, Jaap, Beek, Johannes H. G. M. van

“…The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new…”
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Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase by Harrison, Glenn J, van Wijhe, Michiel H, de Groot, Bas, Dijk, Francina J, Gustafson, Lori A, van Beek, Johannes H G M

“…Creatine kinase (CK) and glycolysis represent important energy-buffering processes in the cardiac myocyte. Although the role of compartmentalized CK in energy…”
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Activation time of myocardial oxidative phosphorylation in creatine kinase and adenylate kinase knockout mice by Gustafson, Lori A, Van Beek, Johannes H G M

“…Our goal was to determine whether mice genetically altered to lack either creatine kinase (M/MtCK(-/-)) or adenylate kinase (AK(-/-)) show altered properties…”
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Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle by Alders, David J C, Groeneveld, A B Johan, Binsl, Thomas W, van Beek, Johannes H G M

“…In normal hearts, myocardial perfusion is fairly well matched to regional metabolic demand, although both are distributed heterogeneously. Nonuniform regional…”
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Regional sympathetic denervation affects the relation between canine local myocardial blood flow and oxygen consumption by Alders, David J. C., Cornelussen, Richard N., Prinzen, Frits W., Specht, Patricia A. C., Noble, Mark I. M., Drake‐Holland, Angela J., De Kanter, Frans J. J., Van Beek, Johannes H. G. M.

“…Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal…”
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