An inherited restriction in the idiotypic variability as a possible explanation of a genetic predisposition for a monoclonal component

Genetic factors have been proposed to play a role in the aetiology of a monoclonal proliferation of B lymphocytes. As an additional genetic factor we postulate that a restriction in the idiotypic variability of an individual contributes to a genetic predisposition to monoclonal gammopathy. To suppor...

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Bibliographic Details
Published in:	Scandinavian journal of immunology Vol. 11; no. 5; p. 511
Main Authors:	Ockhuizen, T, Deenen, G J, van Balen, I M, Mandema, E, Marrink, J
Format:	Journal Article
Language:	English
Published:	England 01-01-1980
Subjects:	Antibody Specificity Antigen-Antibody Reactions Female Genotype Humans Hypergammaglobulinemia - genetics Hypergammaglobulinemia - immunology Immune Sera Immunoglobulin A - genetics Immunoglobulin A - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin kappa-Chains - genetics Immunoglobulin kappa-Chains - immunology Immunoglobulin lambda-Chains - genetics Immunoglobulin lambda-Chains - immunology Immunoglobulin Light Chains - genetics Male Radioimmunoassay Radioligand Assay
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Summary:	Genetic factors have been proposed to play a role in the aetiology of a monoclonal proliferation of B lymphocytes. As an additional genetic factor we postulate that a restriction in the idiotypic variability of an individual contributes to a genetic predisposition to monoclonal gammopathy. To support our hypothesis, we have examined three families with multiple occurrence of M-components for sharing of idiotypic antigenicity between the related M-components and between the M-components and the sera of unaffected relatives. Idiotypic antisera against five isolated M-components were raised in guinea-pigs and used in a radiobinding inhibition assay. In none of the three families was idiotypic cross-reactivity observed between the familial M-components. However, in a family with three members with an M-component, sera of first-degree relatives showed a higher inhibitory capacity than sera of non-related individuals when an idiotypic antiserum, raised against the M-component of proposita, was employed. Within this particular family the observed restriction in the idiotypic variability could have contributed to the multiple occurrence of M-components.
ISSN:	0300-9475
DOI:	10.1111/j.1365-3083.1980.tb00019.x