Search Results - "van Apeldoorn, A A"

Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation by Marchioli, G, van Gurp, L, van Krieken, P P, Stamatialis, D, Engelse, M, van Blitterswijk, C A, Karperien, M B J, de Koning, E, Alblas, J, Moroni, L, van Apeldoorn, A A

“…In clinical islet transplantation, allogeneic islets of Langerhans are transplanted into the portal vein of patients with type 1 diabetes, enabling the…”
Get more information

High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo by Moreira Teixeira, L S, Leijten, J C H, Sobral, J, Jin, R, van Apeldoorn, A A, Feijen, J, van Blitterswijk, C, Dijkstra, P J, Karperien, M

“…Cell-based cartilage repair strategies such as matrix-induced autologous chondrocyte implantation (MACI) could be improved by enhancing cell performance. We…”
Get full text

Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans by Buitinga, Mijke, Truckenmüller, Roman, Engelse, Marten A, Moroni, Lorenzo, Ten Hoopen, Hetty W M, van Blitterswijk, Clemens A, de Koning, Eelco Jp, van Apeldoorn, Aart A, Karperien, Marcel

“…Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patients with type 1 diabetes. However, the suboptimal…”
Get full text

A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets by Smink, Alexandra M, Hertsig, Don T, Schwab, Leendert, van Apeldoorn, Aart A, de Koning, Eelco, Faas, Marijke M, de Haan, Bart J, de Vos, Paul

“…OBJECTIVE:We aim on developing a polymeric ectopic scaffold in a readily accessible site under the skin. SUMMARY BACKGROUND DATA:The liver as transplantation…”
Get full text

Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes by Tol, Maarten C., de Bont, Denise F. A., Boon, Wouter P. C., de Koning, Eelco J. P., van Apeldoorn, Aart A.

“…Islet delivery devices (IDDs) offer potential benefits for islet transplantation and stem cell-based replacement in type 1 diabetes. Little is known about…”
Get full text

In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction by Steins, Anne, Dik, Pieter, Müller, Wally H, Vervoort, Stephin J, Reimers, Kerstin, Kuhbier, Jörn W, Vogt, Peter M, van Apeldoorn, Aart A, Coffer, Paul J, Schepers, Koen

“…Reconstruction of the bladder by means of both natural and synthetic materials remains a challenge due to severe adverse effects such as mechanical failure…”
Get full text

Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement by Lopez-Heredia, Marco A., Sariibrahimoglu, Kemal, Yang, Wanxun, Bohner, Marc, Yamashita, Daiki, Kunstar, Aliz, van Apeldoorn, Aart A., Bronkhorst, Ewald M., Félix Lanao, Rosa P., Leeuwenburgh, Sander C.G., Itatani, Kiyoshi, Yang, Fang, Salmon, Phil, Wolke, Joop G.C., Jansen, John A.

“…Porosity and interconnectivity are important properties of calcium phosphate cements (CPCs) and bone-replacement materials. Porosity of CPCs can be achieved by…”
Get full text

Physicochemical Composition of Osteoporotic Bone in the Trichothiodystrophy Premature Aging Mouse Determined by Confocal Raman Microscopy by van Apeldoorn, Aart A., de Boer, Jan, van Steeg, Harry, Hoeijmakers, Jan H. J., Otto, Cees, van Blitterswijk, Clemens A.

“…Although it has been established that premature aging trichothiodystrophy (TTD) mice display typical signs of osteoporosis, exact changes in physicochemical…”
Get full text

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate) by Deschamps, A.A., van Apeldoorn, A.A., Hayen, H., de Bruijn, J.D., Karst, U., Grijpma, D.W., Feijen, J.

“…Two in vivo degradation studies were performed on segmented poly(ether ester)s based on polyethylene glycol (PEG) and poly(butylene terephthalate) (PBT)…”
Get full text

Raman Imaging of PLGA Microsphere Degradation Inside Macrophages by van Apeldoorn, Aart A, van Manen, Henk-Jan, Bezemer, Jeroen M, de Bruijn, Joost D, van Blitterswijk, Clemens A, Otto, Cees

“…Understanding the degradation behavior of polymeric microspheres is crucial for the successful application of such devices in controlled drug delivery. The…”
Get full text

Poly(ether ester amide)s for tissue engineering by Deschamps, A.A., van Apeldoorn, A.A., de Bruijn, J.D., Grijpma, D.W., Feijen, J.

“…Poly(ether ester amide) (PEEA) copolymers based on poly(ethylene glycol) (PEG), 1,4-butanediol and dimethyl-7,12-diaza-6,13-dione-1,18-octadecanedioate were…”
Get full text

P.117: Preventing Beta-cell Death Using a Palmitoylated JNK Inhibitory Peptide to Block the Apoptotic Pathway by da Silva Filho, Omar Paulino, van Apeldoorn, Aart A.

Get full text

Parallel high-resolution confocal Raman SEM analysis of inorganic and organic bone matrix constituents by van Apeldoorn, A.A, Aksenov, Y, Stigter, M, Hofland, I, de Bruijn, J.D, Koerten, H.K, Otto, C, Greve, J, van Blitterswijk, C.A

“…-formed bone extracellular matrix (ECM) produced by rat osteoprogenitor cells resembles mature bone chemically. We gained insight into the structure and…”
Get full text

The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-ε-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets by Smink, Alexandra M, Li, Shiri, Hertsig, Don T, de Haan, Bart J, Schwab, Leendert, van Apeldoorn, Aart A, de Koning, Eelco, Faas, Marijke M, Lakey, Jonathan R.T, de Vos, Paul

“…BACKGROUNDThe liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to retrieve the graft…”
Get full text

The feasibility of Cryo In‐SEM Raman microspectroscopy by HAZEKAMP, J., REED, M. G., HOWARD, C.V., VAN APELDOORN, A. A., OTTO, C.

“…Summary The combination of noninvasive compositional analysis by Raman microspectrometry with high‐resolution imaging in the scanning electron microscope…”
Get full text

General practitioners' views on cardiovascular prevention for ethnic minorities-a qualitative study in the Netherlands by van Apeldoorn, Joshua A N, Roozekrans, Alet K, Harskamp, Ralf E, Richard, Edo, Agyemang, Charles, Moll van Charante, Eric P

“…While ethnic minorities in Europe are disproportionally affected by cardiovascular disease (CVD), little is known about how general practitioners (GPs)…”
Get full text

Fucoidan Hydrogels Significantly Alleviate Oxidative Stress and Enhance the Endocrine Function of Encapsulated Beta Cells by Reys, Lara L., Vaithilingam, Vijayaganapathy, Sthijns, Mireille M. J. P. E., Soares, Eduardo, Rademakers, Timo, Vries, Rick, Mohammed, Sami G., Bont, Denise, Jetten, Marlon J., Hermanns, Carolin, Filho, Omar Paulino da Silva, Stell, Adam, Mourad, Nizar I., Gianello, Pierre, LaPointe, Vanessa L. S., Silva, Simone S., Reis, Rui L., Silva, Tiago H., Apeldoorn, Aart A.

“…Microencapsulating pancreatic islets in immunoprotective alginate hydrogels is a promising strategy for treatment of type 1 diabetes. However, this strategy is…”
Get full text

Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells by SIEBE SPIJKER, H, RAVELLI, Raimond B. G, MUMMERY, Christine L, CARLOTTI, Françoise, DE KONING, Eelco J. P, MIEKE MOMMAAS-KIENHUIS, A, VAN APELDOORN, Aart A, ENGELSE, Marten A, ZALDUMBIDE, Arnaud, BONNER-WEIR, Susan, RABELINK, Ton J, HOEBEN, Rob C, CLEVERS, Hans

“…Conversion of one terminally differentiated cell type into another (or transdifferentiation) usually requires the forced expression of key transcription…”
Get full text

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans by Marchioli, Giulia, Luca, Andrea Di, de Koning, Eelco, Engelse, Marten, Van Blitterswijk, Clemens A., Karperien, Marcel, Van Apeldoorn, Aart A., Moroni, Lorenzo

“…Although regarded as a promising treatment for type 1 diabetes, clinical islet transplantation in the portal vein is still hindered by a low transplantation…”
Get full text

Adding ethnicity to cardiovascular risk prediction: External validation and model updating of SCORE2 using data from the HELIUS population cohort by van Apeldoorn, Joshua A.N., Hageman, Steven H.J., Harskamp, Ralf E., Agyemang, Charles, van den Born, Bert-Jan H., van Dalen, Jan Willem, Galenkamp, Henrike, Hoevenaar-Blom, Marieke P., Richard, Edo, van Valkengoed, Irene G.M., Visseren, Frank L.J., Dorresteijn, Jannick A.N., Moll van Charante, Eric P.

“…Current prediction models for mainland Europe do not include ethnicity, despite ethnic disparities in cardiovascular disease (CVD) risk. SCORE2 performance was…”
Get full text