Search Results - "van Acker, Gijs J D"

Co-localization hypothesis： A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis by van Acker, Gijs J D, Perides, George, Steer, Michael L

“…Acute pancreatitis is generally believed to be a disease in which the pancreas is injured by digestive enzymes that it normally produces. Most of the…”
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Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis by Van Acker, Gijs J D, Weiss, Eric, Steer, Michael L, Perides, George

“…We have hypothesized that the colocalization of digestive zymogens with lysosomal hydrolases, which occurs during the early stages of every experimental…”
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Alternative specimen extraction techniques after laparoscopic emergency colectomy in inflammatory bowel disease by Gardenbroek, Tjibbe J., Eshuis, Emma J., van Acker, Gijs J. D., Tanis, Pieter J., Bemelman, Willem A.

“…Background Omitting the extraction site incision potentially further decreases the abdominal wall trauma in laparoscopic surgery. The purpose of this study was…”
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Tumor Progression Locus-2 Is a Critical Regulator of Pancreatic and Lung Inflammation during Acute Pancreatitis by Van Acker, Gijs J.D., Perides, George, Weiss, Eric R., Das, Santasabuj, Tsichlis, Philip N., Steer, Michael L.

“…Pancreatic and lung inflammation during acute pancreatitis is a poorly understood, but clinically important, phenomenon. The proto-oncogene Tpl2 (tumor…”
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Experimental acute biliary pancreatitis induced by retrograde infusion of bile acids into the mouse pancreatic duct by Perides, George, Steer, Michael L, van Acker, Gijs JD, Laukkarinen, Johanna M

“…Mechanistic studies of acute pancreatitis require animal models because clinical material is generally not available during the early phases of the disease…”
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A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate by Laukkarinen, Johanna M, Van Acker, Gijs J D, Weiss, Eric R, Steer, Michael L, Perides, George

“…Objective:Most mechanistic studies of pancreatitis in mice employ the secretagogue-induced model. The currently reported studies were designed to develop an…”
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Protease-activated Receptor-2 Exerts Contrasting Model-specific Effects on Acute Experimental Pancreatitis by Laukkarinen, Johanna M., Weiss, Eric R., van Acker, Gijs J.D., Steer, Michael L., Perides, George

“…Protease-activated receptor-2 (PAR2) is a 7-transmembrane G-protein-coupled tethered ligand receptor that is expressed by pancreatic acinar and ductal cells…”
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Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity by Van Acker, Gijs J D, Saluja, Ashok K, Bhagat, Lakshmi, Singh, Vijay P, Song, Albert M, Steer, Michael L

“…Intrapancreatic activation of trypsinogen is believed to play a critical role in the initiation of acute pancreatitis, but mechanisms responsible for…”
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Correlation of CT findings with intra-operative outcome in closed-loop small bowel obstruction (CL-SBO) by de Kok, Bente M., Toneman, Masja K., Oei, Stanley, Westerterp, Marinke, van Acker, Gijs J.D., van der Pool, Anne E.M., Zijta, Frank M., Bipat, Shandra

“…•Closed loop small bowel obstruction is a precursor for bowel wall ischemia and necrosis.•CT findings concerning mesenteric and bowel wall changes correlate…”
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Safety and economic analysis of selective histopathology following cholecystectomy: multicentre, prospective, cross-sectional FANCY study by Bastiaenen, Vivian P, van Vliet, Jaap L P, de Savornin Lohman, Elise A J, Corten, Bartholomeus J G A, de Jonge, Joske, Kraima, Anne C, Swank, Hilko A, van Acker, Gijs J D, van Geloven, Anna A W, In 't Hof, Klaas H, Koens, Lianne, de Reuver, Philip R, van Rossem, Charles C, Slooter, Gerrit D, Tanis, Pieter J, Terpstra, Valeska, Dijkgraaf, Marcel G W, Bemelman, Willem A

“…There is ongoing debate concerning the necessity of routine histopathological examination following cholecystectomy. In order to reduce the pathology workload…”
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Technical Perspective for Video Based Assessment of Surgeries in Low-Resource Settings by van Kesteren, Jurre, van Goudoever, Leandra A.E., Conteh, Amara, van Acker, Gijs J.D., Bonjer, H. Jaap, Bolkan, Håkon A.

“…•Use of surgical training videos in low- and middle-income countries is limited•Chronological steps for shooting a surgical procedure in a low-resource…”
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Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative by Feenstra, Tim M., van Felius, L. Peter, Vriens, Menno R., Stassen, Laurents P. S., van Acker, Gijs J. D., van Dijkum, Els J. M. Nieveen, Schijven, Marlies P., Bonjer, H. Jaap

“…Backgrounds COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital…”
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Predicting the outcome of closed-loop small bowel obstruction by preoperative characteristics by Toneman, Masja K, de Kok, Bente M, Zijta, Frank M, Oei, Stanley, van Acker, Gijs J D, Westerterp, Marinke, van der Pool, Anne E M

“…BACKGROUNDClosed-loop small bowel obstruction (CL-SBO) can threaten the viability of the intestine by obstructing a bowel segment at two adjacent points…”
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Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial by de Groof, E Joline, Buskens, Christianne J, Ponsioen, Cyriel Y, Dijkgraaf, Marcel G W, D'Haens, Geert R A M, Srivastava, Nidhi, van Acker, Gijs J D, Jansen, Jeroen M, Gerhards, Michael F, Dijkstra, Gerard, Lange, Johan F M, Witteman, Ben J M, Kruyt, Philip M, Pronk, Apollo, van Tuyl, Sebastiaan A C, Bodelier, Alexander, Crolla, Rogier M P H, West, Rachel L, Vrijland, Wietske W, Consten, Esther C J, Brink, Menno A, Tuynman, Jurriaan B, de Boer, Nanne K H, Breukink, Stephanie O, Pierik, Marieke J, Oldenburg, Bas, van der Meulen, Andrea E, Bonsing, Bert A, Spinelli, Antonino, Danese, Silvio, Sacchi, Matteo, Warusavitarne, Janindra, Hart, Ailsa, Yassin, Nuha A, Kennelly, Rory P, Cullen, Garret J, Winter, Desmond C, Hawthorne, A Barney, Torkington, Jared, Bemelman, Willem A

“…Currently there is no guideline for the treatment of patients with Crohn's disease and high perianal fistulas. Most patients receive anti-TNF medication, but…”
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Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study by Bastiaenen, Vivian P, Corten, Bartholomeus JGA, de Savornin Lohman, Elise AJ, de Jonge, Joske, Kraima, Anne C, Swank, Hilko A, van Vliet, Jaap LP, van Acker, Gijs JD, van Geloven, Anna AW, in 't Hof, Klaas H, Koens, Lianne, de Reuver, Philip R, van Rossem, Charles C, Slooter, Gerrit D, Tanis, Pieter J, Terpstra, Valeska, Dijkgraaf, Marcel GW, Bemelman, Willem A

“…IntroductionRoutine histopathological examination following appendicectomy and cholecystectomy has significant financial implications and comprises a…”
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Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats by Bhagat, Lakshmi, Singh, Vijay P., Song, Albert M., Van Acker, Gijs J.D., Agrawal, Sudhir, Steer, Michael L., Saluja, Ashok K.

“…Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not…”
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Oncological Safety and Potential Cost Savings of Routine Versus Selective Histopathological Examination Following Appendectomy: Results of the Multicenter, Prospective, Cross-Sectional FANCY Study by Bastiaenen, Vivian P., de Jonge, Joske, Corten, Bartholomeus J. G. A., Lohman, Elise A. J. de Savornin, Kraima, Anne C., Swank, Hilko A., van Vliet, Jaap L. P., van Acker, Gijs J. D., van Geloven, Anna A. W., Hof, Klaas H. ‘t, Koens, Lianne, de Reuver, Philip R., van Rossem, Charles C., Slooter, Gerrit D., Tanis, Pieter J., Terpstra, Valeska, Dijkgraaf, Marcel G. W., Bemelman, Willem A.

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Oncological Safety and Potential Cost Savings of Routine vs Selective Histopathological Examination After Appendectomy: Results of the Multicenter, Prospective, Cross-Sectional FANCY Study by Bastiaenen, Vivian P, de Jonge, Joske, Corten, Bartholomeus J G A, de Savornin Lohman, Elise A J, Kraima, Anne C, Swank, Hilko A, van Vliet, Jaap L P, van Acker, Gijs J D, van Geloven, Anna A W, In 't Hof, Klaas H, Koens, Lianne, de Reuver, Philip R, van Rossem, Charles C, Slooter, Gerrit D, Tanis, Pieter J, Terpstra, Valeska, Dijkgraaf, Marcel G W, Bemelman, Willem A

“…To investigate the oncological safety and potential cost savings of selective histopathological examination after appendectomy. The necessity of routine…”
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Protease-activated Receptor-2 Exerts Contrasting Model-specific Effects on Acute Experimental PancreatitisS by Laukkarinen, Johanna M., Weiss, Eric R., van Acker, Gijs J. D., Steer, Michael L., Perides, George

“…Protease-activated receptor-2 (PAR2) is a 7-transmembrane G-protein-coupled tethered ligand receptor that is expressed by pancreatic acinar and ductal cells…”
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Transpapillary gallbladder drainage with 'pigtail' stent by Toneman, Masja K, Perk, Lars E, van Acker, Gijs J D

“…The transpapillary double 'pigtail' stent is placed endoscopically to drain the gallbladder after remission of a (recurrent) acute cholecystitis in patients…”
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