Search Results - "van Aalten, Daan MF"

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations by Kumar, Atul, Tamjar, Jevgenia, Waddell, Andrew D, Woodroof, Helen I, Raimi, Olawale G, Shaw, Andrew M, Peggie, Mark, Muqit, Miratul Mk, van Aalten, Daan Mf

“…Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase…”
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Tissue-specific O- GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning by Yu, Haibin, Liu, Dandan, Zhang, Yaowen, Tang, Ruijun, Fan, Xunan, Mao, Song, Lv, Lu, Chen, Fang, Qin, Hongtao, Zhang, Zhuohua, van Aalten, Daan M F, Yang, Bing, Yuan, Kai

“…GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation is associated with neurological disorders that…”
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O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release by Pathak, Shalini, Borodkin, Vladimir S, Albarbarawi, Osama, Campbell, David G, Ibrahim, Adel, van Aalten, Daan MF

“…Transforming growth factor (TGF)‐β‐activated kinase 1 (TAK1) is a key serine/threonine protein kinase that mediates signals transduced by pro‐inflammatory…”
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Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope by Lamb, Daniel, Schüttelkopf, Alexander W, van Aalten, Daan M F, Brighty, David W

“…Human T-cell leukaemia virus (HTLV-1) and bovine leukaemia virus (BLV) entry into cells is mediated by envelope glycoprotein catalyzed membrane fusion and is…”
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation by Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK

“…Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that…”
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Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability by Czajewski, Ignacy, Swain, Bijayalaxmi, Xu, Jiawei, McDowall, Laurin, Ferenbach, Andrew T, van Aalten, Daan MF

“…O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations…”
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Pseudokinases-remnants of evolution or key allosteric regulators? by Zeqiraj, Elton, van Aalten, Daan MF

“…Protein kinases provide a platform for the integration of signal transduction networks. A key feature of transmitting these cellular signals is the ability of…”
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Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1 by Zhang, Ning, Gordon, Sarah L, Fritsch, Maximilian J, Esoof, Noor, Campbell, David G, Gourlay, Robert, Velupillai, Srikannathasan, Macartney, Thomas, Peggie, Mark, van Aalten, Daan M F, Cousin, Michael A, Alessi, Dario R

“…Synaptic vesicle protein 2A (SV2A) is a ubiquitous component of synaptic vesicles (SVs). It has roles in both SV trafficking and neurotransmitter release. We…”
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The citron homology domain as a scaffold for Rho1 signaling by Bartual, Sergio G., Wei, Wenfan, Zhou, Yao, Pravata, Veronica M., Fang, Wenxia, Yan, Kaizhou, Ferenbach, Andrew T., Lockhart, Deborah E. A., van Aalten, Daan M. F.

“…Aspergillus fumigatus is a human opportunistic pathogen showing emerging resistance against a limited repertoire of antifungal agents available. The GTPase…”
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Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum by Ostrowski, Adam, Gundogdu, Mehmet, Ferenbach, Andrew T., Lebedev, Andrey A., van Aalten, Daan M.F.

“…Post-translational modification of proteins is a ubiquitous mechanism of signal transduction in all kingdoms of life. One such modification is addition of…”
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The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces by Wong, Edmond, Vaaje-Kolstad, Gustav, Ghosh, Avishek, Hurtado-Guerrero, Ramon, Konarev, Peter V, Ibrahim, Adel F M, Svergun, Dmitri I, Eijsink, Vincent G H, Chatterjee, Nabendu S, van Aalten, Daan M F

“…Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of…”
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Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition by Speakman, Christopher M., Domke, Tanja C.E., Wongpaiboonwattana, Wikrom, Sanders, Kelly, Mudaliar, Manikhandan, van Aalten, Daan M.F., Barton, Geoffrey J., Stavridis, Marios P.

“…The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by…”
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The Non-catalytic Chitin-binding Protein CBP21 from Serratia marcescens Is Essential for Chitin Degradation by Vaaje-Kolstad, Gustav, Horn, Svein J., van Aalten, Daan M.F., Synstad, Bjørnar, Eijsink, Vincent G.H.

“…The Gram-negative soil bacterium Serratia marcescens uses three different family 18 chitinases to degrade chitin, an abundant insoluble carbohydrate polymer…”
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GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP‐4‐dehydrorhamnose reductases (RmlD) by Beek, Samantha L., Le Breton, Yoann, Ferenbach, Andrew T., Chapman, Robert N., Aalten, Daan M. F., Navratilova, Iva, Boons, Geert‐Jan, McIver, Kevin S., Sorge, Nina M., Dorfmueller, Helge C.

“…Summary The sugar nucleotide dTDP‐L‐rhamnose is critical for the biosynthesis of the Group A Carbohydrate, the molecular signature and virulence determinant of…”
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GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation by Dorfmueller, Helge C, Borodkin, Vladimir S, Schimpl, Marianne, van Aalten, Daan M F

“…O-GlcNAcylation is an essential, dynamic and inducible post-translational glycosylation of cytosolic proteins in metazoa and can show interplay with protein…”
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Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes by Kapuria, Vaibhav, Röhrig, Ute F, Bhuiyan, Tanja, Borodkin, Vladimir S, van Aalten, Daan M F, Zoete, Vincent, Herr, Winship

“…In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO-GlcNAcylation of many cellular…”
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Molecular mechanisms of O-GlcNAcylation by Hurtado-Guerrero, Ramon, Dorfmueller, Helge C, van Aalten, Daan MF

“…Protein glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) is a reversible post-translational modification of serines/threonines on metazoan proteins…”
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Crystal Structure and Binding Properties of the Serratia marcescens Chitin-binding Protein CBP21 by Vaaje-Kolstad, Gustav, Houston, Douglas R., Riemen, Anna H.K., Eijsink, Vincent G.H., van Aalten, Daan M.F.

“…Chitin proteins are commonly found in bacteria that utilize chitin as a source of energy. CBP21 is a chitin-binding protein from Serratia marcescens, a…”
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Structure and Metal-Dependent Mechanism of Peptidoglycan Deacetylase, a Streptococcal Virulence Factor by Blair, David E., Alexander W. Schüttelkopf, James I. Mac Rae, Daan M. F. van Aalten

“…Streptococcus pneumoniae peptidoglycan GlcNAc deacetylase (SpPgdA) protects the Gram-positive bacterial cell wall from host lysozymes by deacetylating…”
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Genetic and structural validation of Aspergillus fumigatus UDP‐N‐acetylglucosamine pyrophosphorylase as an antifungal target by Fang, Wenxia, Du, Ting, Raimi, Olawale G., Hurtado‐Guerrero, Ramon, Urbaniak, Michael D., Ibrahim, Adel F. M., Ferguson, Michael A. J., Jin, Cheng, Aalten, Daan M. F.

“…Summary The sugar nucleotide UDP‐N‐acetylglucosamine (UDP‐GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor…”
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