Search Results - "van ’t Hof, Rob"

The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption by Wani, Sachin, Daroszewska, Anna, Salter, Donald M, van 't Hof, Rob J, Ralston, Stuart H, Albagha, Omar M E

“…Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. Genome-wide association studies identified a susceptibility locus for…”
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity by Loveridge, Carolyn J., van ’t Hof, Rob J., Charlesworth, Gemma, King, Ayala, Tan, Ee Hong, Rose, Lorraine, Daroszewska, Anna, Prior, Amanda, Ahmad, Imran, Welsh, Michelle, Mui, Ernest J., Ford, Catriona, Salji, Mark, Sansom, Owen, Blyth, Karen, Leung, Hing Y.

“…Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1 -mediated Cre expression is a useful…”
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Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis by Rebourcet, Diane, O'Shaughnessy, Peter J, Pitetti, Jean-Luc, Monteiro, Ana, O'Hara, Laura, Milne, Laura, Tsai, Yi Ting, Cruickshanks, Lyndsey, Riethmacher, Dieter, Guillou, Florian, Mitchell, Rod T, van't Hof, Rob, Freeman, Tom C, Nef, Serge, Smith, Lee B

“…Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their…”
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Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis by Ramos-Mucci, Lorenzo, Javaheri, Behzad, van 't Hof, Rob, Bou-Gharios, George, Pitsillides, Andrew A, Comerford, Eithne, Poulet, Blandine

“…Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium…”
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IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health by Jaffery, Hussain, Huesa, Carmen, Chilaka, Sabarinadh, Cole, John, Doonan, James, Akbar, Moeed, Dunning, Lynette, Tanner, Kathleen Elizabeth, ‘t Hof, Rob J., McInnes, Iain B., Carmody, Ruaidhrí J., Goodyear, Carl S.

“…Objective IĸB protein B cell lymphoma 3‐encoded protein (BCL3) is a regulator of the NF‐κB family of transcription factors. NF‐κB signaling fundamentally…”
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Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice by Lee, Katie J, Rambault, Lisa, Bou-Gharios, George, Clegg, Peter D, Akhtar, Riaz, Czanner, Gabriela, van 't Hof, Rob, Canty-Laird, Elizabeth G

“…The osteogenesis imperfecta murine (oim) model with solely homotrimeric (α1)3 type I collagen, owing to a dysfunctional α2(I) collagen chain, has a brittle…”
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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology by Huesa, Carmen, Ortiz, Ana C, Dunning, Lynette, McGavin, Laura, Bennett, Louise, McIntosh, Kathryn, Crilly, Anne, Kurowska-Stolarska, Mariola, Plevin, Robin, van 't Hof, Rob J, Rowan, Andrew D, McInnes, Iain B, Goodyear, Carl S, Lockhart, John C, Ferrell, William R

“…Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway…”
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Mitigating lead-induced osteoporosis: The role of butyrate in gut-bone axis restoration by Ge, Yuqiu, Jia, Zhongtang, Zhao, Shiting, Zhang, WenChao, Shi, Xian, Xie, Ruijin, Gong, Yan, Sheng, Jixiang, van 't Hof, Rob J., Yang, Jiatao, Han, Chunqing, Hu, Xiping, Wang, Yafeng, Wu, Yu, Li, Chunping, Wang, Miaomiao

“…Lead (Pb) is an environmentally widespread bone toxic pollutant, contributes to the development of osteoporosis. Butyric acid, mainly produced by the…”
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Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice by Coste, Emmanuel, Greig, Iain R, Mollat, Patrick, Rose, Lorraine, Gray, Mohini, Ralston, Stuart H, van 't Hof, Rob J

“…Inflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic…”
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Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis by Kanakis, Ioannis, Liu, Ke, Poulet, Blandine, Javaheri, Behzad, Hof, Rob J., Pitsillides, Andrew A., Bou‐Gharios, George

“…Objective Cartilage destruction in osteoarthritis (OA) is mediated mainly by matrix metalloproteinases (MMPs) and ADAMTS. The therapeutic candidature of…”
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A comparison of the bone and growth phenotype of mdx , mdx:Cmah -/- and mdx:Utrn +/- murine models with the C57BL/10 wild-type mouse by Wood, Claire L, Suchacki, Karla J, van 't Hof, Rob, Cawthorn, Will P, Dillon, Scott, Straub, Volker, Wong, Sze Choong, Ahmed, Syed F, Farquharson, Colin

“…The muscular dystrophy X-linked ( ) mouse is commonly used as a mouse model of Duchenne muscular dystrophy (DMD). Its phenotype is, however, mild, and other…”
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Open source software for semi-automated histomorphometry of bone resorption and formation parameters by van't Hof, Rob J, Rose, Lorraine, Bassonga, Euphemie, Daroszewska, Anna

“…Abstract Micro-CT analysis has become the standard method for assessing bone volume and architecture in small animals. However, micro-CT does not allow the…”
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Combined growth hormone and insulin-like growth factor-1 rescues growth retardation in glucocorticoid-treated mdxmice but does not prevent osteopenia by Wood, Claire L, van ‘t Hof, Rob, Dillon, Scott, Straub, Volker, Wong, Sze C, Ahmed, S Faisal, Farquharson, Colin

“…Short stature and osteoporosis are common in Duchenne muscular dystrophy (DMD) and its pathophysiology may include an abnormality of the growth…”
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The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis by Beekman, Kerensa M., Veldhuis-Vlug, Annegreet G., den Heijer, Martin, Maas, Mario, Oleksik, Ania M., Tanck, Michael W., Ott, Susan M., van 't Hof, Rob J., Lips, Paul, Bisschop, Peter H., Bravenboer, Nathalie

“…In patients with postmenopausal osteoporosis low bone volume is associated with high bone marrow adipose tissue (MAT). Moreover, high MAT is associated with…”
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Low protein intake during reproduction compromises the recovery of lactation‐induced bone loss in female mouse dams without affecting skeletal muscles by Kanakis, Ioannis, Alameddine, Moussira, Scalabrin, Mattia, ‘t Hof, Rob J., Liloglou, Triantafillos, Ozanne, Susan E., Goljanek‐Whysall, Katarzyna, Vasilaki, Aphrodite

“…Lactation‐induced bone loss occurs due to high calcium requirements for fetal growth but skeletal recovery is normally achieved promptly postweaning. Dietary…”
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Molecular insights into an ancient form of Paget’s disease of bone by Shaw, Barry, Burrell, Carla L., Green, Darrell, Navarro-Martinez, Ana, Scott, Daniel, Daroszewska, Anna, van ’t Hof, Rob, Smith, Lynn, Hargrave, Frank, Mistry, Sharad, Bottrill, Andrew, Kessler, Benedikt M., Fischer, Roman, Singh, Archana, Dalmay, Tamas, Fraser, William D., Henneberger, Kirstin, King, Turi, Gonzalez, Silvia, Layfield, Robert

“…Paget’s disease of bone (PDB) is a chronic skeletal disorder that can affect one or several bones in individuals older than 55 y of age. PDB-like changes have…”
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Identification of Novel Biphenyl Carboxylic Acid Derivatives as Novel Antiresorptive Agents that Do Not Impair Parathyroid Hormone-Induced Bone Formation by Idris, Aymen I, Greig, Iain R, Bassonga-Landao, Euphemie, Ralston, Stuart H, van 't Hof, Rob J

“…Bisphosphonates are widely used in the treatment of osteoporosis, but they inhibit bone formation and blunt the anabolic effect of PTH. Here we describe a…”
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The essential requirement for Runx1 in the development of the sternum by Liakhovitskaia, Anna, Lana-Elola, Eva, Stamateris, Evangelos, Rice, David P., van 't Hof, Rob J., Medvinsky, Alexander

“…Runx1 is highly expressed in chondroprogenitor and osteoprogenitor cells and in vitro experiments suggest that Runx1 is important in the early stages of…”
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Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice by Mackenzie, Neil Charles Wallace, Zhu, Dongxing, Milne, Elspeth M, van 't Hof, Rob, Martin, Aline, Darryl Quarles, Leigh, Quarles, Darryl Leigh, Millán, José Luis, Farquharson, Colin, MacRae, Vicky Elisabeth

“…Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised…”
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ABD56 causes osteoclast apoptosis by inhibiting the NFκB and ERK pathways by Idris, Aymen, Mrak, Emanuela, Greig, Iain, Guidobono, Francesca, Ralston, Stuart H., van ’t Hof, Rob

“…We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However,…”
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