Search Results - "van Wezel, Gilles P."

antiSMASH 6.0: improving cluster detection and comparison capabilities by Blin, Kai, Shaw, Simon, Kloosterman, Alexander M, Charlop-Powers, Zach, van Wezel, Gilles P, Medema, Marnix H, Weber, Tilmann

“…Abstract Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to…”
Get full text

Ecology and genomics of Actinobacteria: new concepts for natural product discovery by van Bergeijk, Doris A., Terlouw, Barbara R., Medema, Marnix H., van Wezel, Gilles P.

“…Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic versatility. They produce most of the clinically used antibiotics and…”
Get full text

Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species by Avalos, Mariana, Garbeva, Paolina, Raaijmakers, Jos M., van Wezel, Gilles P.

“…Soil-inhabiting streptomycetes are nature’s medicine makers, producing over half of all known antibiotics and many other bioactive natural products. However,…”
Get full text

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics by Machushynets, Nataliia V., Elsayed, Somayah S., Du, Chao, Siegler, Maxime A., de la Cruz, Mercedes, Genilloud, Olga, Hankemeier, Thomas, van Wezel, Gilles P.

“…Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging…”
Get full text

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery by Kloosterman, Alexander M., Shelton, Kyle E., van Wezel, Gilles P., Medema, Marnix H., Mitchell, Douglas A.

“…Bioinformatics-powered discovery of novel ribosomal natural products (RiPPs) has historically been hindered by the lack of a common genetic feature across RiPP…”
Get full text

antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation by Blin, Kai, Shaw, Simon, Augustijn, Hannah E, Reitz, Zachary L, Biermann, Friederike, Alanjary, Mohammad, Fetter, Artem, Terlouw, Barbara R, Metcalf, William W, Helfrich, Eric J N, van Wezel, Gilles P, Medema, Marnix H, Weber, Tilmann

“…Abstract Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial,…”
Get full text

Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach by Jansma, Jack, Thome, Nicola U., Schwalbe, Markus, Chatziioannou, Anastasia Chrysovalantou, Elsayed, Somayah S., van Wezel, Gilles P., van den Abbeele, Pieter, van Hemert, Saskia, El Aidy, Sahar

“…The gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host…”
Get full text

Phylogenomic analyses and distribution of terpene synthases among Streptomyces by Martín-Sánchez, Lara, Singh, Kumar Saurabh, Avalos, Mariana, van Wezel, Gilles P, Dickschat, Jeroen S, Garbeva, Paolina

“…Terpene synthases are widely distributed among microorganisms and have been mainly studied in members of the genus . However, little is known about the…”
Get full text

Chemical ecology of antibiotic production by actinomycetes by van der Meij, Anne, Worsley, Sarah F., Hutchings, Matthew I., van Wezel, Gilles P.

“…Abstract Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural products relevant for agriculture, biotechnology and…”
Get full text

Taxonomy, Physiology, and Natural Products of Actinobacteria by Barka, Essaid Ait, Vatsa, Parul, Sanchez, Lisa, Gaveau-Vaillant, Nathalie, Jacquard, Cedric, Meier-Kolthoff, Jan P, Klenk, Hans-Peter, Clément, Christophe, Ouhdouch, Yder, van Wezel, Gilles P

“…Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed…”
Get full text

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets by Świątek-Połatyńska, Magdalena A, Bucca, Giselda, Laing, Emma, Gubbens, Jacob, Titgemeyer, Fritz, Smith, Colin P, Rigali, Sébastien, van Wezel, Gilles P

“…Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and…”
Get full text

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides by Kloosterman, Alexander M, Cimermancic, Peter, Elsayed, Somayah S, Du, Chao, Hadjithomas, Michalis, Donia, Mohamed S, Fischbach, Michael A, van Wezel, Gilles P, Medema, Marnix H

“…Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them…”
Get full text

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome by Carrión, Víctor J, Perez-Jaramillo, Juan, Cordovez, Viviane, Tracanna, Vittorio, de Hollander, Mattias, Ruiz-Buck, Daniel, Mendes, Lucas W, van Ijcken, Wilfred F J, Gomez-Exposito, Ruth, Elsayed, Somayah S, Mohanraju, Prarthana, Arifah, Adini, van der Oost, John, Paulson, Joseph N, Mendes, Rodrigo, van Wezel, Gilles P, Medema, Marnix H, Raaijmakers, Jos M

“…Microorganisms living inside plants can promote plant growth and health, but their genomic and functional diversity remain largely elusive. Here, metagenomics…”
Get full text

Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production by Sulheim, Snorre, Kumelj, Tjaša, van Dissel, Dino, Salehzadeh-Yazdi, Ali, Du, Chao, van Wezel, Gilles P., Nieselt, Kay, Almaas, Eivind, Wentzel, Alexander, Kerkhoven, Eduard J.

“…Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the…”
Get full text

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances by van Wezel, Gilles P, McDowall, Kenneth J

“…Streptomycetes and other actinobacteria are renowned as a rich source of natural products of clinical, agricultural and biotechnological value. They are being…”
Get more information

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era by van der Heul, Helga U, Bilyk, Bohdan L, McDowall, Kenneth J, Seipke, Ryan F, van Wezel, Gilles P

“…Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has brought prominence to the Streptomycetaceae, a family of Gram-positive…”
Get more information

Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies by Claessen, Dennis, Rozen, Daniel E., Kuipers, Oscar P., Søgaard-Andersen, Lotte, van Wezel, Gilles P.

“…Key Points Bacterial multicellularity takes several phenotypically diverse forms and has independently evolved in different species. Simple bacterial…”
Get full text

Anthracyclines: biosynthesis, engineering and clinical applications by Hulst, Mandy B, Grocholski, Thadee, Neefjes, Jacques J C, van Wezel, Gilles P, Metsä-Ketelä, Mikko

“…Covering: January 1995 to June 2021Anthracyclines are glycosylated microbial natural products that harbour potent antiproliferative activities. Doxorubicin has…”
Get more information

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces by van Bergeijk, Doris A., Elsayed, Somayah S., Du, Chao, Santiago, Isabel Nuñez, Roseboom, Anna M., Zhang, Le, Carrión, Victor J., Spaink, Herman P., van Wezel, Gilles P.

“…Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be…”
Get full text

Triggers and cues that activate antibiotic production by actinomycetes by Zhu, Hua, Sandiford, Stephanie K., van Wezel, Gilles P.

“…Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the majority of the known antibiotics. The increasing difficulty to…”
Get full text