Search Results - "van der Heyden, Michael"
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Semaphorin 3A receptor inhibitor as a novel therapeutic to promote innervation of bioengineered teeth
Published in Journal of tissue engineering and regenerative medicine (01-04-2018)“…The sensory innervation of the dental pulp is essential for tooth function and protection. It is mediated by axons originating from the trigeminal ganglia and…”
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Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model
Published in Cell reports (Cambridge) (01-10-2013)“…The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in…”
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Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo
Published in The Journal of biological chemistry (01-06-2024)“…Neuraminidases (NEUs) also called sialidases are glycosidases which catalyze the removal of terminal sialic acid residues from glycoproteins, glycolipids, and…”
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AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients
Published in Oncotarget (15-11-2014)“…Angiogenesis represents a rate-limiting step during tumor progression. Targeting angiogenesis is already applied in cancer treatment, yet limits of…”
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Disruption of Sema3A/Plexin‐A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination
Published in EMBO molecular medicine (07-11-2019)“…Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions…”
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Spatial organization of the tenascin-C microenvironment in experimental and human cancer
Published in Cell adhesion & migration (01-01-2015)“…The extracellular matrix (ECM) molecule tenascin-C (TNC) promotes tumor progression. This has recently been demonstrated in the stochastic murine RIP1-Tag2…”
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The adhesion modulating properties of tenascin-W
Published in International journal of biological sciences (01-01-2012)“…Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by…”
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ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting
Published in The Journal of cell biology (02-11-2020)“…The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM…”
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Tenascin-C increases lung metastasis by impacting blood vessel invasions
Published in Matrix biology (01-10-2019)“…Metastasis is a major cause of death in cancer patients. The extracellular matrix molecule tenascin-C is a known promoter of metastasis, however the underlying…”
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Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides
Published in Cancers (22-10-2019)“…Components with self-assembly properties derived from plant viruses provide the opportunity to design biological nanoscaffolds for the ordered display of…”
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