Search Results - "van Unen, Vincent"

ImaCytE: Visual Exploration of Cellular Micro-Environments for Imaging Mass Cytometry Data by Somarakis, Antonios, Van Unen, Vincent, Koning, Frits, Lelieveldt, Boudewijn, Hollt, Thomas

“…Tissue functionality is determined by the characteristics of tissue-resident cells and their interactions within their microenvironment. Imaging Mass Cytometry…”
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Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire by Voogd, Linda, Drittij, Anne M.H.F., Dingenouts, Calinda K.E., Franken, Kees L.M.C., Unen, Vincent van, van Meijgaarden, Krista E., Ruibal, Paula, Hagedoorn, Renate S., Leitner, Judith A., Steinberger, Peter, Heemskerk, Mirjam H.M., Davis, Mark M., Scriba, Thomas J., Ottenhoff, Tom H.M., Joosten, Simone A.

“…HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their…”
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Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types by van Unen, Vincent, Höllt, Thomas, Pezzotti, Nicola, Li, Na, Reinders, Marcel J. T., Eisemann, Elmar, Koning, Frits, Vilanova, Anna, Lelieveldt, Boudewijn P. F.

“…Mass cytometry allows high-resolution dissection of the cellular composition of the immune system. However, the high-dimensionality, large size, and non-linear…”
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Progenitor identification and SARS-CoV-2 infection in human distal lung organoids by Salahudeen, Ameen A., Choi, Shannon S., Rustagi, Arjun, Zhu, Junjie, van Unen, Vincent, de la O, Sean M., Flynn, Ryan A., Margalef-Català, Mar, Santos, António J. M., Ju, Jihang, Batish, Arpit, Usui, Tatsuya, Zheng, Grace X. Y., Edwards, Caitlin E., Wagar, Lisa E., Luca, Vincent, Anchang, Benedict, Nagendran, Monica, Nguyen, Khanh, Hart, Daniel J., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Harbury, Pehr B., Glenn, Jeffrey S., Garcia, K. Christopher, Davis, Mark M., Baric, Ralph S., Sabatti, Chiara, Amieva, Manuel R., Blish, Catherine A., Desai, Tushar J., Kuo, Calvin J.

“…The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would…”
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KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 by Li, Jing, Zaslavsky, Maxim, Su, Yapeng, Guo, Jing, Sikora, Michael J, van Unen, Vincent, Christophersen, Asbjørn, Chiou, Shin-Heng, Chen, Liang, Li, Jiefu, Ji, Xuhuai, Wilhelmy, Julie, McSween, Alana M, Palanski, Brad A, Mallajosyula, Venkata Vamsee Aditya, Bracey, Nathan A, Dhondalay, Gopal Krishna R, Bhamidipati, Kartik, Pai, Joy, Kipp, Lucas B, Dunn, Jeffrey E, Hauser, Stephen L, Oksenberg, Jorge R, Satpathy, Ansuman T, Robinson, William H, Dekker, Cornelia L, Steinmetz, Lars M, Khosla, Chaitan, Utz, Paul J, Sollid, Ludvig M, Chien, Yueh-Hsiu, Heath, James R, Fernandez-Becker, Nielsen Q, Nadeau, Kari C, Saligrama, Naresha, Davis, Mark M

“…In this work, we find that CD8 T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49 CD8 regulatory T…”
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High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity by de Vries, Natasja L, van Unen, Vincent, Ijsselsteijn, Marieke E, Abdelaal, Tamim, van der Breggen, Ruud, Farina Sarasqueta, Arantza, Mahfouz, Ahmed, Peeters, Koen C M J, Höllt, Thomas, Lelieveldt, Boudewijn P F, Koning, Frits, de Miranda, Noel F C C

“…A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled…”
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Memory CD4+ T cells are generated in the human fetal intestine by Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P. F., Koning, Frits

“…The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO + T cells reside in the fetal intestine. Here we combined functional assays…”
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Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer by Welters, Marij J P, Ma, Wenbo, Santegoets, Saskia J A M, Goedemans, Renske, Ehsan, Ilina, Jordanova, Ekaterina S, van Ham, Vanessa J, van Unen, Vincent, Koning, Frits, van Egmond, Sylvia I, Charoentong, Pornpimol, Trajanoski, Zlatko, van der Velden, Lilly-Ann, van der Burg, Sjoerd H

“…Human papillomavirus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) has a much better prognosis than HPV-negative OPSCC, and this is linked to…”
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High-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass spectrometry for the determination of membranous receptor expression levels in breast cancer cell lines using receptor-specific hybrid tracers by Van Acker, Thibaut, Buckle, Tessa, Van Malderen, Stijn J.M., van Willigen, Danny M., van Unen, Vincent, van Leeuwen, Fijs W.B., Vanhaecke, Frank

“…This work evaluates the possibility of placement of high-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass…”
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Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease by Mayassi, Toufic, Ladell, Kristin, Gudjonson, Herman, McLaren, James E., Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie, Price, David A., Jabri, Bana

“…Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic…”
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Predicting Cell Populations in Single Cell Mass Cytometry Data by Abdelaal, Tamim, Unen, Vincent, Höllt, Thomas, Koning, Frits, Reinders, Marcel J.T., Mahfouz, Ahmed

“…Mass cytometry by time‐of‐flight (CyTOF) is a valuable technology for high‐dimensional analysis at the single cell level. Identification of different cell…”
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Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine by Li, Na, van Unen, Vincent, Höllt, Thomas, Thompson, Allan, van Bergen, Jeroen, Pezzotti, Nicola, Eisemann, Elmar, Vilanova, Anna, Chuva de Sousa Lopes, Susana M, Lelieveldt, Boudewijn P F, Koning, Frits

“…Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although several ILC subsets have been…”
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Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets by van Unen, Vincent, Li, Na, Molendijk, Ilse, Temurhan, Mine, Höllt, Thomas, van der Meulen-de Jong, Andrea E., Verspaget, Hein W., Mearin, M. Luisa, Mulder, Chris J., van Bergen, Jeroen, Lelieveldt, Boudewijn P.F., Koning, Frits

“…Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role…”
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Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice by Ding, Jie, Lee, Sung-Jin, Vlahos, Lukas, Yuki, Kanako, Rada, Cara C., van Unen, Vincent, Vuppalapaty, Meghah, Chen, Hui, Sura, Asmiti, McCormick, Aaron K., Tomaske, Madeline, Alwahabi, Samira, Nguyen, Huy, Nowatzke, William, Kim, Lily, Kelly, Lisa, Vollrath, Douglas, Califano, Andrea, Yeh, Wen-Chen, Li, Yang, Kuo, Calvin J.

“…Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and…”
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CyteGuide: Visual Guidance for Hierarchical Single-Cell Analysis by Hollt, Thomas, Pezzotti, Nicola, van Unen, Vincent, Koning, Frits, Lelieveldt, Boudewijn P. F., Vilanova, Anna

“…Single-cell analysis through mass cytometry has become an increasingly important tool for immunologists to study the immune system in health and disease. Mass…”
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Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus by Laban, Sandra, Suwandi, Jessica S, van Unen, Vincent, Pool, Jos, Wesselius, Joris, Höllt, Thomas, Pezzotti, Nicola, Vilanova, Anna, Lelieveldt, Boudewijn P F, Roep, Bart O

“…Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these…”
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Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity by de Jong, Sanne E., van Unen, Vincent, Manurung, Mikhael D., Stam, Koen A., Goeman, Jelle J., Jochems, Simon P., Höllt, Thomas, Pezzotti, Nicola, Mouwenda, Yoanne D., Betouke Ongwe, Madeleine Eunice, Lorenz, Freia-Raphaella, Kruize, Yvonne C. M., Azimi, Shohreh, König, Marion H., Vilanova, Anna, Eisemann, Elmar, Lelieveldt, Boudewijn P. F., Roestenberg, Meta, Sim, B. Kim Lee, Reinders, Marcel J. T., Fendel, Rolf, Hoffman, Stephen L., Kremsner, Peter G., Koning, Frits, Mordmüller, Benjamin, Lell, Bertrand, Yazdanbakhsh, Maria

“…Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine…”
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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation by Guo, Nannan, Li, Na, Jia, Li, Jiang, Qinyue, Schreurs, Mette, van Unen, Vincent, de Sousa Lopes, Susana M. Chuva, Vloemans, Alexandra A., Eggermont, Jeroen, Lelieveldt, Boudewijn, Staal, Frank J. T., de Miranda, Noel F. C. C., Pascutti, M. Fernanda, Koning, Frits

“…The intestine represents the largest immune compartment in the human body, yet its development and organisation during human foetal development is largely…”
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Mass cytometric analysis unveils a disease-specific immune cell network in the bone marrow in acquired aplastic anemia by Pool, Emma S, Kooy-Winkelaar, Yvonne, van Unen, Vincent, Falkenburg, J H Frederik, Koning, Frits, Heemskerk, Mirjam H M, Tjon, Jennifer M-L

“…Idiopathic acquired aplastic anemia (AA) is considered an immune-mediated syndrome of bone marrow failure since approximately 70% of patients respond to…”
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A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue by Guo, Nannan, van Unen, Vincent, Ijsselsteijn, Marieke E, Ouboter, Laura F, van der Meulen, Andrea E, Chuva de Sousa Lopes, Susana M, de Miranda, Noel F C C, Koning, Frits, Li, Na

“…Imaging mass cytometry (IMC) is able to quantify the expression of dozens of markers at sub-cellular resolution on a single tissue section by combining a novel…”
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