Search Results - "van Schaik, Willem"
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Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era
Published in Current opinion in microbiology (01-02-2013)“…Highlights ► Enterococci are ancient commensals in the GI tracts of hosts ranging from insects to man. ► Enterococci are now leading causes of multidrug…”
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Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system
Published in FEMS microbiology ecology (01-07-2018)“…Effluents from wastewater treatment plants (WWTPs) have been proposed to act as point sources of antibiotic-resistant bacteria (ARB) and antimicrobial…”
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Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial
Published in Nature communications (16-02-2022)“…Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of…”
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Core Genome Multilocus Sequence Typing Scheme for High- Resolution Typing of Enterococcus faecium
Published in Journal of clinical microbiology (01-12-2015)“…Enterococcus faecium, a common inhabitant of the human gut, has emerged in the last 2 decades as an important multidrug-resistant nosocomial pathogen. Since…”
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The human gut resistome
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-06-2015)“…In recent decades, the emergence and spread of antibiotic resistance among bacterial pathogens has become a major threat to public health. Bacteria can acquire…”
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CRISPR-Cas9-mediated genome editing in vancomycin-resistant Enterococcus faecium
Published in FEMS microbiology letters (01-11-2019)“…ABSTRACT The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections…”
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Enterobacteriaceae and Bacteroidaceae provide resistance to travel-associated intestinal colonization by multi-drug resistant Escherichia coli
Published in Gut microbes (31-12-2022)“…Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among international travelers…”
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Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects
Published in Microbiome (14-08-2017)“…The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an…”
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Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium
Published in PLoS genetics (01-06-2012)“…Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance…”
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AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity
Published in PLoS pathogens (01-08-2012)“…Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses in microorganisms. Here, we identified an oxidative…”
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Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates
Published in mSphere (11-03-2020)“…Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically…”
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Global Regulator CodY Regulates Toxin Gene Expression in Bacillus anthracis and Is Required for Full Virulence
Published in Infection and Immunity (01-10-2009)“…In gram-positive bacteria, CodY is an important regulator of genes whose expression changes upon nutrient limitation and acts as a repressor of virulence gene…”
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Horizontal transfer of antibiotic resistance genes in the human gut microbiome
Published in Current opinion in microbiology (01-02-2020)“…•The human gut microbiome harbours antibiotic resistance genes (‘the resistome’).•Antibiotic resistance genes can spread in the gut microbiome through…”
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Characterization of Enterococcus Isolates Colonizing the Intestinal Tract of Intensive Care Unit Patients Receiving Selective Digestive Decontamination
Published in Frontiers in microbiology (28-08-2017)“…Enterococci have emerged as important opportunistic pathogens in intensive care units (ICUs). In this study, enterococcal population size and isolates…”
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Challenges and opportunities for whole‐genome sequencing–based surveillance of antibiotic resistance
Published in Annals of the New York Academy of Sciences (01-01-2017)“…Infections caused by drug‐resistant bacteria are increasingly reported across the planet, and drug‐resistant bacteria are recognized to be a major threat to…”
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Baas Becking meets One Health
Published in Nature microbiology (01-04-2022)“…“Everything is everywhere, but, the environment selects” — a hypothesis formulated by Lourens Baas Becking in 1934 — is used to frame research that analyses…”
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Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis
Published in Clinical microbiology reviews (01-10-2017)“…Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient populations in hospitals around the world. Intensive care unit (ICU)…”
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The Recombinase IntA Is Required for Excision of esp-Containing ICEEfm1 in Enterococcus faecium
Published in Journal of Bacteriology (01-02-2011)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of a Novel Genomic Island Specific to Hospital-Acquired Clonal Complex 17 Enterococcus faecium Isolates
Published in Applied and Environmental Microbiology (01-11-2008)“…Hospital-acquired clonal complex 17 (CC17) Enterococcus faecium strains are genetically distinct from indigenous strains and are enriched with resistance genes…”
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On the (im)possibility of reconstructing plasmids from whole-genome short-read sequencing data
Published in Microbial genomics (01-10-2017)“…To benchmark algorithms for automated plasmid sequence reconstruction from short-read sequencing data, we selected 42 publicly available complete bacterial…”
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