Search Results - "van Royen, Martin E"

Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP by Groeneweg, Femke L, van Royen, Martin E, Fenz, Susanne, Keizer, Veer I P, Geverts, Bart, Prins, Jurrien, de Kloet, E Ron, Houtsmuller, Adriaan B, Schmidt, Thomas S, Schaaf, Marcel J M

“…Recent advances in live cell imaging have provided a wealth of data on the dynamics of transcription factors. However, a consistent quantitative description of…”
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Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals by Zaeck, Luca M., Lamers, Mart M., Verstrepen, Babs E., Bestebroer, Theo M., van Royen, Martin E., Götz, Hannelore, Shamier, Marc C., van Leeuwen, Leanne P. M., Schmitz, Katharina S., Alblas, Kimberley, van Efferen, Suzanne, Bogers, Susanne, Scherbeijn, Sandra, Rimmelzwaan, Guus F., van Gorp, Eric C. M., Koopmans, Marion P. G., Haagmans, Bart L., GeurtsvanKessel, Corine H., de Vries, Rory D.

“…In July 2022, the ongoing monkeypox (MPX) outbreak was declared a public health emergency of international concern. Modified vaccinia Ankara—Bavarian Nordic…”
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Extracellular Vesicle Quantification and Characterization: Common Methods and Emerging Approaches by Hartjes, Thomas A, Mytnyk, Serhii, Jenster, Guido W, van Steijn, Volkert, van Royen, Martin E

“…Extracellular vesicles (EVs) are a family of small membrane vesicles that carry information about cells by which they are secreted. Growing interest in the…”
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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling by Schmitt, Mark, Schewe, Matthias, Sacchetti, Andrea, Feijtel, Danny, van de Geer, Wesley S., Teeuwssen, Miriam, Sleddens, Hein F., Joosten, Rosalie, van Royen, Martin E., van de Werken, Harmen J.G., van Es, Johan, Clevers, Hans, Fodde, Riccardo

“…IBD syndromes such as Crohn’s disease and ulcerative colitis result from the inflammation of specific intestinal segments. Although many studies have reported…”
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Structure of the homodimeric androgen receptor ligand-binding domain by Nadal, Marta, Prekovic, Stefan, Gallastegui, Nerea, Helsen, Christine, Abella, Montserrat, Zielinska, Karolina, Gay, Marina, Vilaseca, Marta, Taulès, Marta, Houtsmuller, Adriaan B., van Royen, Martin E., Claessens, Frank, Fuentes-Prior, Pablo, Estébanez-Perpiñá, Eva

“…The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the aetiology and treatment of diverse…”
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Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer by Schewe, Matthias, Franken, Patrick F., Sacchetti, Andrea, Schmitt, Mark, Joosten, Rosalie, Böttcher, René, van Royen, Martin E., Jeammet, Louise, Payré, Christine, Scott, Patricia M., Webb, Nancy R., Gelb, Michael, Cormier, Robert T., Lambeau, Gérard, Fodde, Riccardo

“…The intestinal stem cell niche provides cues that actively maintain gut homeostasis. Dysregulation of these cues may compromise intestinal regeneration upon…”
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DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II by Steurer, Barbara, Janssens, Roel C., Geijer, Marit E., Aprile-Garcia, Fernando, Geverts, Bart, Theil, Arjan F., Hummel, Barbara, van Royen, Martin E., Evers, Bastiaan, Bernards, René, Houtsmuller, Adriaan B., Sawarkar, Ritwick, Marteijn, Jurgen

“…The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is crucial for proper execution of the DNA damage-induced stress…”
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Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles by Blijdorp, Charles J, Tutakhel, Omar A Z, Hartjes, Thomas A, van den Bosch, Thierry P P, van Heugten, Martijn H, Rigalli, Juan Pablo, Willemsen, Rob, Musterd-Bhaggoe, Usha M, Barros, Eric R, Carles-Fontana, Roger, Carvajal, Cristian A, Arntz, Onno J, van de Loo, Fons A J, Jenster, Guido, Clahsen-van Groningen, Marian C, Cuevas, Cathy A, Severs, David, Fenton, Robert A, van Royen, Martin E, Hoenderop, Joost G J, Bindels, René J M, Hoorn, Ewout J

“…Urinary extracellular vesicles (uEVs) are a promising source for biomarker discovery, but optimal approaches for normalization, quantification, and…”
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Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation by Liebelt, Frauke, Schimmel, Joost, Verlaan – de Vries, Matty, Klemann, Esra, van Royen, Martin E, van der Weegen, Yana, Luijsterburg, Martijn S, Mullenders, Leon H, Pines, Alex, Vermeulen, Wim, Vertegaal, Alfred C O

“…Abstract Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB…”
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SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models by Mykytyn, Anna Z, Breugem, Tim I, Geurts, Maarten H, Beumer, Joep, Schipper, Debby, van Acker, Romy, van den Doel, Petra B, van Royen, Martin E, Zhang, Jingshu, Clevers, Hans, Haagmans, Bart L, Lamers, Mart M

“…SARS-CoV-2 can enter cells after its spike protein is cleaved by either type II transmembrane serine proteases (TTSPs), like TMPRSS2, or cathepsins. It is now…”
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The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide by Prekovic, Stefan, van Royen, Martin E, Voet, Arnout R D, Geverts, Bart, Houtman, Rene, Melchers, Diana, Zhang, Kam Y J, Van den Broeck, Thomas, Smeets, Elien, Spans, Lien, Houtsmuller, Adriaan B, Joniau, Steven, Claessens, Frank, Helsen, Christine

“…Treatment-induced mutations in the ligand-binding domain of the androgen receptor (AR) are known to change antagonists into agonists. Recently, the F877L…”
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Human branching cholangiocyte organoids recapitulate functional bile duct formation by Roos, Floris J.M., van Tienderen, Gilles S., Wu, Haoyu, Bordeu, Ignacio, Vinke, Dina, Albarinos, Laura Muñoz, Monfils, Kathryn, Niesten, Sabrah, Smits, Ron, Willemse, Jorke, Rosmark, Oskar, Westergren-Thorsson, Gunilla, Kunz, Daniel J., de Wit, Maurice, French, Pim J., Vallier, Ludovic, IJzermans, Jan N.M., Bartfai, Richard, Marks, Hendrik, Simons, Ben D., van Royen, Martin E., Verstegen, Monique M.A., van der Laan, Luc J.W.

“…Human cholangiocyte organoids show great promise for regenerative therapies and in vitro modeling of bile duct development and diseases. However, the cystic…”
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Three-dimensional microscopic analysis of clinical prostate specimens by van Royen, Martin E, Verhoef, Esther I, Kweldam, Charlotte F, van Cappellen, Wiggert A, Kremers, Gert-Jan, Houtsmuller, Adriaan B, van Leenders, Geert J L H

“…Aims Microscopic evaluation of prostate specimens for both clinical and research purposes is generally performed on 5‐μm‐thick tissue sections. Because…”
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Compartmentalization of androgen receptors at endogenous genes in living cells by Yavuz, Selçuk, Kabbech, Hélène, van Staalduinen, Jente, Linder, Simon, van Cappellen, Wiggert A, Nigg, Alex L, Abraham, Tsion E, Slotman, Johan A, Quevedo, Marti, Poot, Raymond A, Zwart, Wilbert, van Royen, Martin E, Grosveld, Frank G, Smal, Ihor, Houtsmuller, Adriaan B

“…Abstract A wide range of nuclear proteins are involved in the spatio-temporal organization of the genome through diverse biological processes such as gene…”
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Three-dimensional analysis reveals two major architectural subgroups of prostate cancer growth patterns by Verhoef, Esther I., van Cappellen, Wiggert A., Slotman, Johan A., Kremers, Gert-Jan, Ewing-Graham, Patricia C., Houtsmuller, Adriaan B., van Royen, Martin E., van Leenders, Geert J. L. H.

“…The Gleason score is one of the most important parameters for therapeutic decision-making in prostate cancer patients. Gleason growth patterns are defined by…”
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Scenarios of future mpox outbreaks among men who have sex with men: a modelling study based on cross-sectional seroprevalence data from the Netherlands, 2022 by Shamier, Marc C, Zaeck, Luca M, Götz, Hannelore M, Vieyra, Bruno, Verstrepen, Babs E, Wijnans, Koen, Welkers, Matthijs Ra, Hoornenborg, Elske, van Cleef, Brigitte Agl, van Royen, Martin E, Jonas, Kai J, Koopmans, Marion Pg, de Vries, Rory D, van de Vijver, David Amc, GeurtsvanKessel, Corine H

“…BackgroundFollowing the 2022-2023 mpox outbreak, crucial knowledge gaps exist regarding orthopoxvirus-specific immunity in risk groups and its impact on future…”
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Novel FXXFF and FXXMF Motifs in Androgen Receptor Cofactors Mediate High Affinity and Specific Interactions with the Ligand-binding Domain by van de Wijngaart, Dennis J., van Royen, Martin E., Hersmus, Remko, Pike, Ashley C.W., Houtsmuller, Adriaan B., Jenster, Guido, Trapman, Jan, Dubbink, Hendrikus J.

“…Upon hormone binding, a hydrophobic coactivator binding groove is induced in the androgen receptor (AR) ligand-binding domain (LBD). This groove serves as high…”
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Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer by Vitale, Silvia R, Helmijr, Jean A, Gerritsen, Marjolein, Coban, Hicret, van Dessel, Lisanne F, Beije, Nick, van der Vlugt-Daane, Michelle, Vigneri, Paolo, Sieuwerts, Anieta M, Dits, Natasja, van Royen, Martin E, Jenster, Guido, Sleijfer, Stefan, Lolkema, Martijn, Martens, John W M, Jansen, Maurice P H M

“…Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study…”
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TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A by Pines, Alex, Dijk, Madelon, Makowski, Matthew, Meulenbroek, Elisabeth M., Vrouwe, Mischa G., van der Weegen, Yana, Baltissen, Marijke, French, Pim J., van Royen, Martin E., Luijsterburg, Martijn S., Mullenders, Leon H., Vermeulen, Michiel, Vermeulen, Wim, Pannu, Navraj S., van Attikum, Haico

“…Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by…”
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Phase Separation Mediated Sub-Nuclear Compartmentalization of Androgen Receptors by Yavuz, Selçuk, Abraham, Tsion E, Houtsmuller, Adriaan B, van Royen, Martin E

“…The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of transcription factors, plays a crucial role not only in the development…”
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