Search Results - "van Petegem, Filip"

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM by Woll, Kellie A., Haji-Ghassemi, Omid, Van Petegem, Filip

“…Ryanodine Receptors (RyRs) are massive channels that release Ca 2+ from the endoplasmic and sarcoplasmic reticulum. Hundreds of mutations are linked to…”
Get full text

Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain by Yuchi, Zhiguang, Lau, Kelvin, Van Petegem, Filip

“…Ryanodine Receptors (RyRs) are huge Ca2+ release channels in the endoplasmic reticulum membrane and form targets for phosphorylation and disease mutations. We…”
Get full text

Structural basis for diamide modulation of ryanodine receptor by Ma, Ruifang, Haji-Ghassemi, Omid, Ma, Dan, Jiang, Heng, Lin, Lianyun, Yao, Li, Samurkas, Arthur, Li, Yuxin, Wang, Yiwen, Cao, Peng, Wu, Shian, Zhang, Yan, Murayama, Takashi, Moussian, Bernard, Van Petegem, Filip, Yuchi, Zhiguang

“…The diamide insecticide class is one of the top-selling insecticides globally. They are used to control a wide range of pests by targeting their ryanodine…”
Get full text

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations by Yang, Zheng Fang, Panwar, Pankaj, McFarlane, Ciaran R, Tuinte, Wietske E, Campiglio, Marta, Van Petegem, Filip

“…SignificanceIon channels have evolved the ability to communicate with one another, either through protein-protein interactions, or indirectly via intermediate…”
Get full text

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease by Scortecci, Jessica Fernandes, Molday, Laurie L., Curtis, Susan B., Garces, Fabian A., Panwar, Pankaj, Van Petegem, Filip, Molday, Robert S.

“…ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of…”
Get full text

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant by Yuchi, Zhiguang, Yuen, Siobhan M. Wong King, Lau, Kelvin, Underhill, Ainsley Q., Cornea, Razvan L., Fessenden, James D., Van Petegem, Filip

“…Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in…”
Get full text

Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification by Asghari, Parisa, Scriven, David Rl, Ng, Myles, Panwar, Pankaj, Chou, Keng C, van Petegem, Filip, Moore, Edwin Dw

“…The effects of the immunophilins, FKBP12 and FKBP12.6, and phosphorylation on type II ryanodine receptor (RyR2) arrangement and function were examined using…”
Get full text

Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry by Roston, Thomas M, Haji-Ghassemi, Omid, LaPage, Martin J, Batra, Anjan S, Bar-Cohen, Yaniv, Anderson, Chris, Lau, Yung R, Maginot, Kathleen, Gebauer, Roman A, Etheridge, Susan P, Potts, James E, Van Petegem, Filip, Sanatani, Shubhayan

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is often a life-threatening arrhythmia disorder with variable penetrance and expressivity. Little…”
Get full text

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms by Lau, Kelvin, Chan, Mandy M. Y, Van Petegem, Filip

“…Ryanodine receptors (RyRs) are large ion channels that are responsible for the release of Ca2+ from the sarcoplasmic/endoplasmic reticulum. Calmodulin (CaM) is…”
Get full text

Seeing the Forest through the Trees: towards a Unified View on Physiological Calcium Regulation of Voltage-Gated Sodium Channels by Van Petegem, Filip, Lobo, Paolo A., Ahern, Christopher A.

“…Voltage-gated sodium channels (NaVs) underlie the upstroke of the action potential in the excitable tissues of nerve and muscle. After opening, NaVs rapidly…”
Get full text

Ryanodine Receptors: Allosteric Ion Channel Giants by Van Petegem, Filip

“…The endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) form major intracellular Ca2+ stores. Ryanodine receptors (RyRs) are large tetrameric ion…”
Get full text

RNA Polymerase II transcription independent of TBP in murine embryonic stem cells by Kwan, James Z J, Nguyen, Thomas F, Uzozie, Anuli C, Budzynski, Marek A, Cui, Jieying, Lee, Joseph M C, Van Petegem, Filip, Lange, Philipp F, Teves, Sheila S

“…Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have…”
Get full text

The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations by Kimlicka, Lynn, Tung, Ching-Chieh, Carlsson, Anna-Carin Cecilia, Lobo, Paolo Antonio, Yuchi, Zhiguang, Van Petegem, Filip

“…Ryanodine receptors (RyRs) are calcium release channels located in the membrane of the endoplasmic and sarcoplasmic reticulum and play a major role in muscle…”
Get full text

The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching by Lobo, Paolo A., Kimlicka, Lynn, Tung, Ching-Chieh, Van Petegem, Filip

“…Mutations in the cardiac Ryanodine Receptor (RYR2) are linked to triggered arrhythmias. Removal of exon 3 results in a severe form of catecholaminergic…”
Get full text

A Novel RYR2 Loss-of-Function Mutation (I4855M) is Associated with Left Ventricular Non-compaction and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia by Roston, Thomas M., MD, Guo, Wenting, MSc, Krahn, Andrew D., MD, Wang, Ruiwu, PhD, van Petegem, Filip, PhD, Sanatani, Shubhayan, MD, Chen, S.R. Wayne, PhD, Lehman, Anna, MD

“…Abstract Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion channelopathy usually caused by gain-of-function mutations ryanodine…”
Get full text

Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors by Woll, Kellie A, Van Petegem, Filip

“…Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine…”
Get full text

Talin Autoinhibition Is Required for Morphogenesis by Ellis, Stephanie J., Goult, Benjamin T., Fairchild, Michael J., Harris, Nathan J., Long, Jenny, Lobo, Paolo, Czerniecki, Stefan, Van Petegem, Filip, Schöck, Frieder, Peifer, Mark, Tanentzapf, Guy

“…The establishment of a multicellular body plan requires coordinating changes in cell adhesion and the cytoskeleton to ensure proper cell shape and position…”
Get full text

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC by Stevens, Charles M., Rayani, Kaveh, Genge, Christine E., Singh, Gurpreet, Liang, Bo, Roller, Janine M., Li, Cindy, Li, Alison Yueh, Tieleman, D. Peter, van Petegem, Filip, Tibbits, Glen F.

“…Zebrafish, as a model for teleost fish, have two paralogous troponin C (TnC) genes that are expressed in the heart differentially in response to temperature…”
Get full text

Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation–contraction coupling by Rufenach, Britany, Van Petegem, Filip

“…In skeletal muscle tissue, an intriguing mechanical coupling exists between two ion channels from different membranes: the L-type voltage-gated calcium channel…”
Get full text

Binary architecture of the Nav1.2-β2 signaling complex by Das, Samir, Gilchrist, John, Bosmans, Frank, Van Petegem, Filip

“…To investigate the mechanisms by which β-subunits influence Nav channel function, we solved the crystal structure of the β2 extracellular domain at 1.35Å. We…”
Get full text