Search Results - "van Noort, John"

Chromatin fibers stabilize nucleosomes under torsional stress by Kaczmarczyk, Artur, Meng, He, Ordu, Orkide, Noort, John van, Dekker, Nynke H.

“…Torsional stress generated during DNA replication and transcription has been suggested to facilitate nucleosome unwrapping and thereby the progression of…”
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Quantitative analysis of single-molecule force spectroscopy on folded chromatin fibers by Meng, He, Andresen, Kurt, van Noort, John

“…Single-molecule techniques allow for picoNewton manipulation and nanometer accuracy measurements of single chromatin fibers. However, the complexity of the…”
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Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo by Arias-Alpizar, Gabriela, Kong, Li, Vlieg, Redmar C., Rabe, Alexander, Papadopoulou, Panagiota, Meijer, Michael S., Bonnet, Sylvestre, Vogel, Stefan, van Noort, John, Kros, Alexander, Campbell, Frederick

“…Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any encapsulated contents, in vivo. Herein, we describe, and visualise…”
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Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis by Cortijo, Sandra, Charoensawan, Varodom, Brestovitsky, Anna, Buning, Ruth, Ravarani, Charles, Rhodes, Daniela, van Noort, John, Jaeger, Katja E., Wigge, Philip A.

“…Temperature influences the distribution, range, and phenology of plants. The key transcriptional activators of heat shock response in eukaryotes, the heat…”
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A critical role for linker DNA in higher-order folding of chromatin fibers by Brouwer, Thomas, Pham, Chi, Kaczmarczyk, Artur, de Voogd, Willem-Jan, Botto, Margherita, Vizjak, Petra, Mueller-Planitz, Felix, van Noort, John

“…Abstract Nucleosome-nucleosome interactions drive the folding of nucleosomal arrays into dense chromatin fibers. A better physical account of the folding of…”
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Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach by Eslami-Mossallam, Behrouz, Schram, Raoul D, Tompitak, Marco, van Noort, John, Schiessel, Helmut

“…Eukaryotic DNA is strongly bent inside fundamental packaging units: the nucleosomes. It is known that their positions are strongly influenced by the mechanical…”
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Coexistence of Twisted, Plectonemic, and Melted DNA in Small Topological Domains by Meng, He, Bosman, Johan, van der Heijden, Thijn, van Noort, John

“…DNA responds to small changes in force and torque by over- or undertwisting, forming plectonemes, and/or melting bubbles. Although transitions between either…”
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Mechanical and structural properties of archaeal hypernucleosomes by Henneman, Bram, Brouwer, Thomas B, Erkelens, Amanda M, Kuijntjes, Gert-Jan, van Emmerik, Clara, van der Valk, Ramon A, Timmer, Monika, Kirolos, Nancy C S, van Ingen, Hugo, van Noort, John, Dame, Remus T

“…Abstract Many archaea express histones, which organize the genome and play a key role in gene regulation. The structure and function of archaeal histone–DNA…”
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Parallel Nanometric 3D Tracking of Intracellular Gold Nanorods Using Multifocal Two-Photon Microscopy by van den Broek, Bram, Ashcroft, Brian, Oosterkamp, Tjerk H, van Noort, John

“…We report a novel technique for long-term parallel three dimensional (3D)-tracking of gold nanorods in live cells with nanometer resolution. Gold nanorods…”
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Overcoming chromatin barriers by de Jong, Babette E, van Noort, John

“…Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy…”
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Single-molecule structural and kinetic studies across sequence space by Severins, Ivo, Bastiaanssen, Carolien, Kim, Sung Hyun, Simons, Roy B, van Noort, John, Joo, Chirlmin

“…At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic…”
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A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation by Neumann, Heinz, Hancock, Susan M., Buning, Ruth, Routh, Andrew, Chapman, Lynda, Somers, Joanna, Owen-Hughes, Tom, van Noort, John, Rhodes, Daniela, Chin, Jason W.

“…Lysine acetylation of histones defines the epigenetic status of human embryonic stem cells and orchestrates DNA replication, chromosome condensation,…”
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Unraveling DNA Organization with Single-Molecule Force Spectroscopy Using Magnetic Tweezers by Brouwer, Thomas B, Kaczmarczyk, Artur, Pham, Chi, van Noort, John

“…Genomes carry the genetic blueprint of all living organisms. Their organization requires strong condensation as well as carefully regulated accessibility to…”
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Reconstituted TAD-size chromatin fibers feature heterogeneous nucleosome clusters by Korolev, Nikolay, Zinchenko, Anatoly, Soman, Aghil, Chen, Qinming, Wong, Sook Yi, Berezhnoy, Nikolay V., Basak, Rajib, van der Maarel, Johan R. C., van Noort, John, Nordenskiöld, Lars

“…Large topologically associated domains (TADs) contain irregularly spaced nucleosome clutches, and interactions between such clutches are thought to aid the…”
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Sequence-based prediction of single nucleosome positioning and genome-wide nucleosome occupancy by van der Heijden, Thijn, van Vugt, Joke J.F.A, Logie, Colin, van Noort, John

“…Nucleosome positioning dictates eukaryotic DNA compaction and access. To predict nucleosome positions in a statistical mechanics model, we exploited the…”
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Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin by Hermans, Nicolaas, Huisman, Juriën Jori, Brouwer, Thomas Bauke, Schächner, Christopher, van Heusden, G. Paul H., Griesenbeck, Joachim, van Noort, John

“…The organization of DNA into chromatin is thought to regulate gene expression in eukaryotes. To study its structure in vitro , there is a need for techniques…”
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Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue by Gora, Radoslaw J, de Jong, Babette, van Hage, Patrick, Rhiemus, Mary Ann, van Steenis, Fjodor, van Noort, John, Schmidt, Thomas, Schaaf, Marcel J M

“…Developments in single-molecule microscopy (SMM) have enabled imaging individual proteins in biological systems, focusing on the analysis of protein mobility…”
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Dual Architectural Roles of HU: Formation of Flexible Hinges and Rigid Filaments by van Noort, John, Verbrugge, Sander, Goosen, Nora, Dekker, Cees, Dame, Remus Thei, Cozzarelli, Nicholas R.

“…The nucleoid-associated protein HU is one of the most abundant proteins in Escherichia coli and has been suggested to play an important role in bacterial…”
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10 years of tension on chromatin: results from single molecule force spectroscopy by Chien, Fan-Tso, van Noort, John

“…The compact, yet dynamic organization of chromatin plays an essential role in regulating gene expression. Although the static structure of chromatin fibers has…”
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Accuracy of the detection of binding events using 3D single particle tracking by Carozza, Sara, Culkin, Jamie, van Noort, John

“…Nanoparticles can be used as markers to track the position of biomolecules, such as single proteins, inside living cells. The activity of a protein can…”
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