Search Results - "van Es, Johan"

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer by Dow, Lukas E., O’Rourke, Kevin P., Simon, Janelle, Tschaharganeh, Darjus F., van Es, Johan H., Clevers, Hans, Lowe, Scott W.

“…The adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling…”
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Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium by Stange, Daniel E., Koo, Bon-Kyoung, Huch, Meritxell, Sibbel, Greg, Basak, Onur, Lyubimova, Anna, Kujala, Pekka, Bartfeld, Sina, Koster, Jan, Geahlen, Jessica H., Peters, Peter J., van Es, Johan H., van de Wetering, Marc, Mills, Jason C., Clevers, Hans

“…Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate…”
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Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters by Tetteh, Paul W., Basak, Onur, Farin, Henner F., Wiebrands, Kay, Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, de Sauvage, Frederic, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

“…Intestinal crypts display robust regeneration upon injury. The relatively rare secretory precursors can replace lost stem cells, but it is unknown if the…”
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Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids by Lõhmussaar, Kadi, Kopper, Oded, Korving, Jeroen, Begthel, Harry, Vreuls, Celien P. H., van Es, Johan H., Clevers, Hans

“…High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine…”
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Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche by Chakrabarti, Rumela, Celià-Terrassa, Toni, Kumar, Sushil, Hang, Xiang, Wei, Yong, Choudhury, Abrar, Hwang, Julie, Peng, Jia, Nixon, Briana, Grady, John J, DeCoste, Christina, Gao, Jie, van Es, Johan H, Li, Ming O, Aifantis, Iannis, Clevers, Hans, Kang, Yibin

“…The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway…”
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Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas by Schepers, Arnout G., Snippert, Hugo J., Stange, Daniel E., van den Born, Maaike, van Es, Johan H., van de Wetering, Marc, Clevers, Hans

“…The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains…”
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De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data by Grün, Dominic, Muraro, Mauro J., Boisset, Jean-Charles, Wiebrands, Kay, Lyubimova, Anna, Dharmadhikari, Gitanjali, van den Born, Maaike, van Es, Johan, Jansen, Erik, Clevers, Hans, de Koning, Eelco J.P., van Oudenaarden, Alexander

“…Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell…”
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Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand by Boj, Sylvia F., van Es, Johan H., Huch, Meritxell, Li, Vivian S.W., José, Anabel, Hatzis, Pantelis, Mokry, Michal, Haegebarth, Andrea, van den Born, Maaike, Chambon, Pierre, Voshol, Peter, Dor, Yuval, Cuppen, Edwin, Fillat, Cristina, Clevers, Hans

“…Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on a role of the encoded transcription factor TCF4 in β cells. Here, a…”
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Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium by Gerbe, François, van Es, Johan H, Makrini, Leila, Brulin, Bénédicte, Mellitzer, Georg, Robine, Sylvie, Romagnolo, Béatrice, Shroyer, Noah F, Bourgaux, Jean-François, Pignodel, Christine, Clevers, Hans, Jay, Philippe

“…The unique morphology of tuft cells was first revealed by electron microscopy analyses in several endoderm-derived epithelia. Here, we explore the relationship…”
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A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche by Artegiani, Benedetta, Lyubimova, Anna, Muraro, Mauro, van Es, Johan H., van Oudenaarden, Alexander, Clevers, Hans

“…Adult neurogenesis in the murine dentate gyrus occurs in a specialized microenvironment that sustains the generation of neurons during life. To fully…”
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Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition by Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.

“…BET family proteins are novel therapeutic targets for cancer and inflammation and represent the first chromatin readers against which small-molecule inhibitors…”
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Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia by Koo, Bon-Kyoung, Johan H. van Es, Maaike van den Born, Hans Clevers

“…Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that…”
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration by Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., Li, Vivian S. W., van de Wetering, Marc, Sato, Toshiro, Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Vries, Robert G., Grompe, Markus, Clevers, Hans

“…A mouse model of liver damage has identified a population of Lrg5 + liver stem cells that can generate hepatoctyes and bile ducts in vivo. Wake-up call for…”
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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium by Sato, Toshiro, Stange, Daniel E, Ferrante, Marc, Vries, Robert G.J, van Es, Johan H, van den Brink, Stieneke, van Houdt, Winan J, Pronk, Apollo, van Gorp, Joost, Siersema, Peter D, Clevers, Hans

“…Background & Aims We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over…”
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Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids by Artegiani, Benedetta, van Voorthuijsen, Lisa, Lindeboom, Rik G.H., Seinstra, Daniëlle, Heo, Inha, Tapia, Pablo, López-Iglesias, Carmen, Postrach, Daniel, Dayton, Talya, Oka, Rurika, Hu, Huili, van Boxtel, Ruben, van Es, Johan H., Offerhaus, Johan, Peters, Peter J., van Rheenen, Jacco, Vermeulen, Michiel, Clevers, Hans

“…The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in cholangiocarcinoma. BAP1 has many proposed molecular targets, while its…”
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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage by van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Yee Nee, Annie Ng, Gregorieff, Alex, Sasaki, Nobuo, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C. M., Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans

“…Notch signalling in the intestinal crypt is modulated to drive commitment to the secretory fate. Clevers and colleagues find that cells expressing the Notch…”
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Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells by Snippert, Hugo J., van der Flier, Laurens G., Sato, Toshiro, van Es, Johan H., van den Born, Maaike, Kroon-Veenboer, Carla, Barker, Nick, Klein, Allon M., van Rheenen, Jacco, Simons, Benjamin D., Clevers, Hans

“…Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at the small intestinal crypt base and divide every day. We have…”
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Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis by Huch, Meritxell, Bonfanti, Paola, Boj, Sylvia F, Sato, Toshiro, Loomans, Cindy J M, van de Wetering, Marc, Sojoodi, Mozhdeh, Li, Vivian S W, Schuijers, Jurian, Gracanin, Ana, Ringnalda, Femke, Begthel, Harry, Hamer, Karien, Mulder, Joyce, van Es, Johan H, de Koning, Eelco, Vries, Robert G J, Heimberg, Harry, Clevers, Hans

“…Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐spondins (RSPOs). Intestinal, stomach and liver Lgr5 + stem…”
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Crypt stem cells as the cells-of-origin of intestinal cancer by van de Wetering, Marc, van Es, Johan H, Sansom, Owen J, Begthel, Harry, van den Born, Maaike, Barker, Nick, Danenberg, Esther, Clarke, Alan R, Clevers, Hans, Ridgway, Rachel A

“…Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin…”
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Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon by Sasaki, Nobuo, Sachs, Norman, Wiebrands, Kay, Ellenbroek, Saskia I. J., Fumagalli, Arianna, Lyubimova, Anna, Begthel, Harry, van den Born, Maaike, van Es, Johan H., Karthaus, Wouter R., Li, Vivian S. W., López-Iglesias, Carmen, Peters, Peter J., van Rheenen, Jacco, van Oudenaarden, Alexander, Clevers, Hans

“…Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small…”
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