Search Results - "van Dam, Sipko"

Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging by Wood, Shona H, van Dam, Sipko, Craig, Thomas, Tacutu, Robi, O'Toole, Amy, Merry, Brian J, de Magalhães, João Pedro

“…Caloric restriction (CR) can increase longevity in rodents and improve memory function in humans. α-Lipoic acid (LA) has been shown to improve memory function…”
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GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases by van Dam, Sipko, Cordeiro, Rui, Craig, Thomas, van Dam, Jesse, Wood, Shona H, de Magalhães, João Pedro

“…Although many diseases have been well characterized at the molecular level, the underlying mechanisms are often unknown. Nearly half of all human genes remain…”
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Gene co-expression analysis for functional classification and gene-disease predictions by van Dam, Sipko, Võsa, Urmo, van der Graaf, Adriaan, Franke, Lude, de Magalhães, João Pedro

“…Abstract Gene co-expression networks can be used to associate genes of unknown function with biological processes, to prioritize candidate disease genes or to…”
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GeneFriends: a human RNA-seq-based gene and transcript co-expression database by van Dam, Sipko, Craig, Thomas, de Magalhães, João Pedro

“…Co-expression networks have proven effective at assigning putative functions to genes based on the functional annotation of their co-expressed partners, in…”
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Insights into the Evolution of Longevity from the Bowhead Whale Genome by Keane, Michael, Semeiks, Jeremy, Webb, Andrew E., Li, Yang I., Quesada, Víctor, Craig, Thomas, Madsen, Lone Bruhn, van Dam, Sipko, Brawand, David, Marques, Patrícia I., Michalak, Pawel, Kang, Lin, Bhak, Jong, Yim, Hyung-Soon, Grishin, Nick V., Nielsen, Nynne Hjort, Heide-Jørgensen, Mads Peter, Oziolor, Elias M., Matson, Cole W., Church, George M., Stuart, Gary W., Patton, John C., George, J. Craig, Suydam, Robert, Larsen, Knud, López-Otín, Carlos, O’Connell, Mary J., Bickham, John W., Thomsen, Bo, de Magalhães, João Pedro

“…The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective…”
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Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer by Edogbanya, Jacob, Tejada‐Martinez, Daniela, Jones, Nigel J., Jaiswal, Amit, Bell, Sarah, Cordeiro, Rui, van Dam, Sipko, Rigden, Daniel J., de Magalhães, João Pedro

“…The C1ORF112 gene initially drew attention when it was found to be strongly co‐expressed with several genes previously associated with cancer and implicated in…”
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A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels by Monaco, Gianni, van Dam, Sipko, Casal Novo Ribeiro, João Luis, Larbi, Anis, de Magalhães, João Pedro

“…A deeper understanding of differences and similarities in transcriptional regulation between species can uncover important information about gene functions and…”
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The necessity of incorporating non-genetic risk factors into polygenic risk score models by van Dam, Sipko, Folkertsma, Pytrik, Castela Forte, Jose, de Vries, Dylan H., Herrera Cunillera, Camila, Gannamani, Rahul, Wolffenbuttel, Bruce H. R.

“…The growing public interest in genetic risk scores for various health conditions can be harnessed to inspire preventive health action. However, current…”
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Effect of a Digitally-Enabled, Preventive Health Program on Blood Pressure in an Adult, Dutch General Population Cohort: An Observational Pilot Study by Castela Forte, José, Folkertsma, Pytrik, Gannamani, Rahul, Kumaraswamy, Sridhar, van Dam, Sipko, Hoogsteen, Jan

“…Worldwide, it is estimated that at least one in four adults suffers from hypertension, and this number is expected to increase as populations grow and age…”
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A Pilot Study on the Prevalence of Micronutrient Imbalances in a Dutch General Population Cohort and the Effects of a Digital Lifestyle Program by Castela Forte, José, Gannamani, Rahul, Folkertsma, Pytrik, Kanthappu, Saro, van Dam, Sipko, Wolffenbuttel, Bruce H R

“…Maintaining an adequate micronutrient status can be achieved by following a complete, diverse diet. Yet, food trends in Western countries show suboptimal…”
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A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms by Plank, Michael, Wuttke, Daniel, van Dam, Sipko, Clarke, Susan A, de Magalhães, João Pedro

“…Caloric restriction, a reduction in calorie intake without malnutrition, retards age-related degeneration and extends lifespan in several organisms. CR induces…”
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A Digitally Enabled Combined Lifestyle Intervention for Weight Loss: Pilot Study in a Dutch General Population Cohort by Gannamani, Rahul, Castela Forte, José, Folkertsma, Pytrik, Hermans, Sven, Kumaraswamy, Sridhar, van Dam, Sipko, Chavannes, Niels, van Os, Hendrikus, Pijl, Hanno, Wolffenbuttel, Bruce H R

“…Overweight and obesity rates among the general population of the Netherlands keep increasing. Combined lifestyle interventions (CLIs) focused on physical…”
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Changes in Blood Lipid Levels After a Digitally Enabled Cardiometabolic Preventive Health Program: Pre-Post Study in an Adult Dutch General Population Cohort by Castela Forte, José, Gannamani, Rahul, Folkertsma, Pytrik, Kumaraswamy, Sridhar, Mount, Sarah, van Dam, Sipko, Hoogsteen, Jan

“…Despite widespread education, many individuals fail to follow basic health behaviors such as consuming a healthy diet and exercising. Positive changes in…”
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Development and Validation of Decision Rules Models to Stratify Coronary Artery Disease, Diabetes, and Hypertension Risk in Preventive Care: Cohort Study of Returning UK Biobank Participants by Castela Forte, José, Folkertsma, Pytrik, Gannamani, Rahul, Kumaraswamy, Sridhar, Mount, Sarah, de Koning, Tom J, van Dam, Sipko, Wolffenbuttel, Bruce H R

“…Many predictive models exist that predict risk of common cardiometabolic conditions. However, a vast majority of these models do not include genetic risk…”
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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases by de Klein, Niek, Tsai, Ellen A., Vochteloo, Martijn, Baird, Denis, Huang, Yunfeng, Chen, Chia-Yen, van Dam, Sipko, Oelen, Roy, Deelen, Patrick, Bakker, Olivier B., El Garwany, Omar, Ouyang, Zhengyu, Marshall, Eric E., Zavodszky, Maria I., van Rheenen, Wouter, Bakker, Mark K., Veldink, Jan, Gaunt, Tom R., Runz, Heiko, Franke, Lude, Westra, Harm-Jan

“…Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized…”
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GDF-15 improves the predictive capacity of Steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies by Kokkorakis, Michail, Folkertsma, Pytrik, Forte, José Castela, Wolffenbuttel, Bruce H.R., van Dam, Sipko, Mantzoros, Christos S.

“…Noninvasive tools (NITs) are currently used to stratify the risk of having or developing hepatic steatosis or fibrosis. Their performance and a…”
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Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies by Acuna-Hidalgo, Rocio, Deriziotis, Pelagia, Steehouwer, Marloes, Gilissen, Christian, Graham, Sarah A, van Dam, Sipko, Hoover-Fong, Julie, Telegrafi, Aida B, Destree, Anne, Smigiel, Robert, Lambie, Lindsday A, Kayserili, Hülya, Altunoglu, Umut, Lapi, Elisabetta, Uzielli, Maria Luisa, Aracena, Mariana, Nur, Banu G, Mihci, Ercan, Moreira, Lilia M A, Borges Ferreira, Viviane, Horovitz, Dafne D G, da Rocha, Katia M, Jezela-Stanek, Aleksandra, Brooks, Alice S, Reutter, Heiko, Cohen, Julie S, Fatemi, Ali, Smitka, Martin, Grebe, Theresa A, Di Donato, Nataliya, Deshpande, Charu, Vandersteen, Anthony, Marques Lourenço, Charles, Dufke, Andreas, Rossier, Eva, Andre, Gwenaelle, Baumer, Alessandra, Spencer, Careni, McGaughran, Julie, Franke, Lude, Veltman, Joris A, De Vries, Bert B A, Schinzel, Albert, Fisher, Simon E, Hoischen, Alexander, van Bon, Bregje W

“…Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of…”
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Effective questionnaire-based prediction models for type 2 diabetes across several ethnicities: a model development and validation study by Kokkorakis, Michail, Folkertsma, Pytrik, van Dam, Sipko, Sirotin, Nicole, Taheri, Shahrad, Chagoury, Odette, Idaghdour, Youssef, Henning, Robert H., Forte, José Castela, Mantzoros, Christos S., de Vries, Dylan H., Wolffenbuttel, Bruce H.R.

“…Type 2 diabetes disproportionately affects individuals of non-White ethnicity through a complex interaction of multiple factors. Therefore, early disease…”
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Gathering insights on disease etiology from gene expression profiles of healthy tissues by Silva, A. Sofia, Wood, Shona H., van Dam, Sipko, Berres, Sven, McArdle, Anne, de Magalhães, João Pedro

“…Motivation: Gene expression profiles have been widely used to study disease states. It may be possible, however, to gather insights into human diseases by…”
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Development and Exploitation of GeneFriends: An Online Database for Gene and Transcript Co-Expression Analysis by van Dam, Sipko

“…Although many diseases have been well characterized at the molecular level, the underlying mechanisms often remain unclear. This may be attributed to the large…”
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