Search Results - "van Bruggen, Nick"

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning by Liu, Yi, Basty, Nicolas, Whitcher, Brandon, Bell, Jimmy D, Sorokin, Elena P, van Bruggen, Nick, Thomas, E Louise, Cule, Madeleine

“…Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been…”
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The future of humans as model organisms by FitzGerald, Garret, Botstein, David, Califf, Robert, Collins, Rory, Peters, Keith, Van Bruggen, Nick, Rader, Dan

“…A “human phenomic science” approach could accelerate personalized medicine Ten years ago, Nobel laureate Sydney Brenner remarked, “We don't have to search for…”
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Death Receptors DR6 and TROY Regulate Brain Vascular Development by Tam, Stephen J., Richmond, David L., Kaminker, Joshua S., Modrusan, Zora, Martin-McNulty, Baby, Cao, Tim C., Weimer, Robby M., Carano, Richard A.D., van Bruggen, Nick, Watts, Ryan J.

“…Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By…”
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FDG-PET Imaging for Oxidized LDL in Stable Atherosclerotic Disease: A Phase II Study of Safety, Tolerability, and Anti-Inflammatory Activity by Lehrer-Graiwer, Joshua, MPhil, MD, Singh, Parmanand, MD, Abdelbaky, Amr, MD, Vucic, Esad, MD, Korsgren, Magnus, MD, PhD, Baruch, Amos, PhD, Fredrickson, Jill, PhD, van Bruggen, Nick, PhD, Tang, Meina T., PhD, Frendeus, Bjorn, PhD, Rudd, James H.F., PhD, Hsieh, Frank, PhD, Ballantyne, Christie M., MD, Ghoshhajra, Brian, MD, MBA, Rosenson, Robert S., MD, Koren, Michael, MD, Roth, Eli M., MD, Duprez, Daniel A., MD, PhD, Fayad, Zahi A., PhD, Tawakol, Ahmed A., MD

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Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response by Sampath, Deepak, Oeh, Jason, Wyatt, Shelby K, Cao, Tim C, Koeppen, Hartmut, Eastham-Anderson, Jeffrey, Robillard, Liliane, Ho, Calvin C.K, Ross, Jed, Zhuang, Guanglei, Reslan, Hani Bou, Vitorino, Philip, Barck, Kai H, Ungersma, Sharon E, Vernes, Jean Michel, Caunt, Maresa, Van Bruggen, Nick, Ye, Weilan, Vijapurkar, Ulka, Meng, Yu-Ju Gloria, Ferrara, Napoleone, Friedman, Lori S, Carano, Richard A.D

“…Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery…”
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Evidence for a Protective Role of Metallothionein-1 in Focal Cerebral Ischemia by Menno van Lookeren Campagne, Thibodeaux, Harold, van Bruggen, Nick, Cairns, Belinda, Gerlal, Robert, Palmer, James T., Williams, Simon P., Lowe, David G.

“…Metallothioneins (MTs) are a family of metal binding proteins that have been proposed to participate in a cellular defense against zinc toxicity and free…”
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Assessing tumor angiogenesis using macromolecular MR imaging contrast media by Brasch, R, Pham, C, Shames, D, Roberts, T, van Dijke, K, van Bruggen, N, Mann, J, Ostrowitzki, S, Melnyk, O

“…MRI enhanced with a macromolecular contrast medium (MMCM) has previously been shown to estimate tumor microvascular characteristics that correlate closely with…”
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Increased Binding Activity at an Antioxidant-Responsive Element in the Metallothionein-1 Promoter and Rapid Induction of Metallothionein-1 and -2 in Response to Cerebral Ischemia and Reperfusion by Campagne, Menno van Lookeren, Thibodeaux, Harold, van Bruggen, Nick, Cairns, Belinda, Lowe, David G

“…Metallothioneins (MTs) are cysteine-rich metal-binding proteins that are potentially involved in zinc homeostasis and free radical scavenging. The expression…”
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Magnetic Resonance Imaging Detects Suppression of Tumor Vascular Permeability After Administration of Antibody to Vascular Endothelial Growth Factor by Pham, Christine D., Roberts, Timothy P. L., Van Bruggen, Nick, Melnyk, Ostap, Mann, Jeffry, Ferrara, Napoleon, Cohen, Robert L., Brasch, Robert C.

“…Macromolecular contrast medium-enhanced magnetic resonance imaging (MR/) and tumor-volume measurements were applied to monitor the effects of anti-vascular…”
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Experimental cerebral venous thrombosis: evaluation using magnetic resonance imaging by Röther, J, Waggie, K, van Bruggen, N, de Crespigny, A J, Moseley, M E

“…Diffusion-weighted (DWI), dynamic contrast-enhanced (perfusion imaging), and conventional spin-echo magnetic resonance imaging (MRI) were applied to…”
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The promise and reality of therapeutic discovery from large cohorts by Melamud, Eugene, Taylor, D Leland, Sethi, Anurag, Cule, Madeleine, Baryshnikova, Anastasia, Saleheen, Danish, van Bruggen, Nick, FitzGerald, Garret A

“…Technological advances in rapid data acquisition have transformed medical biology into a data mining field, where new data sets are routinely dissected and…”
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The promise and reality of therapeutic discovery from large cohorts by Melamud, Eugene, Taylor, D. Leland, Sethi, Anurag, Cule, Madeleine, Baryshnikova, Anastasia, Saleheen, Danish, van Bruggen, Nick, FitzGerald, Garret A

“…Technological advances in rapid data acquisition have transformed medical biology into a data mining field, where new data sets are routinely dissected and…”
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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology by Xiao, Haopeng, Bozi, Luiz H.M., Sun, Yizhi, Riley, Christopher L., Philip, Vivek M., Chen, Mandy, Li, Jiaming, Zhang, Tian, Mills, Evanna L., Emont, Margo P., Sun, Wenfei, Reddy, Anita, Garrity, Ryan, Long, Jiani, Becher, Tobias, Vitas, Laura Potano, Laznik-Bogoslavski, Dina, Ordonez, Martha, Liu, Xinyue, Chen, Xiong, Wang, Yun, Liu, Weihai, Tran, Nhien, Liu, Yitong, Zhang, Yang, Cypess, Aaron M., White, Andrew P., He, Yuchen, Deng, Rebecca, Schöder, Heiko, Paulo, Joao A., Jedrychowski, Mark P., Banks, Alexander S., Tseng, Yu-Hua, Cohen, Paul, Tsai, Linus T., Rosen, Evan D., Klein, Samuel, Chondronikola, Maria, McAllister, Fiona E., Van Bruggen, Nick, Huttlin, Edward L., Spiegelman, Bruce M., Churchill, Gary A., Gygi, Steven P., Chouchani, Edward T.

“…Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse…”
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PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth by Bais, Carlos, Wu, Xiumin, Yao, Jenny, Yang, Suya, Crawford, Yongping, McCutcheon, Krista, Tan, Christine, Kolumam, Ganesh, Vernes, Jean-Michel, Eastham-Anderson, Jeffrey, Haughney, Peter, Kowanetz, Marcin, Hagenbeek, Thijs, Kasman, Ian, Reslan, Hani Bou, Ross, Jed, Van Bruggen, Nick, Carano, Richard A.D., Meng, Yu-Ju Gloria, Hongo, Jo-Anne, Stephan, Jean- Philippe, Shibuya, Masabumi, Ferrara, Napoleone

“…It has been recently reported that treatment with an anti-placenta growth factor (PlGF) antibody inhibits metastasis and primary tumor growth. Here we show…”
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Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response12 by Sampath, Deepak, Oeh, Jason, Wyatt, Shelby K, Cao, Tim C, Koeppen, Hartmut, Eastham-Anderson, Jeffrey, Robillard, Liliane, Ho, Calvin C K, Ross, Jed, Zhuang, Guanglei, Reslan, Hani Bou, Vitorino, Philip, Barck, Kai H, Ungersma, Sharon E, Vernes, Jean Michel, Caunt, Maresa, Van Bruggen, Nick, Ye, Weilan, Vijapurkar, Ulka, Meng, Yu-Ju Gloria, Ferrara, Napoleone, Friedman, Lori S, Carano, Richard A D

“…The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small…”
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Magnetic resonance imaging assessment of cerebral hemodynamics during spreading depression in rats by de Crespigny, A, Röther, J, van Bruggen, N, Beaulieu, C, Moseley, M E

“…High-speed magnetic resonance imaging was used to perform simultaneous measurements of relative cerebral blood volume (rCBV) and water diffusion changes during…”
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Transient focal cerebral ischemia induces sensorimotor deficits in mice by Gerlai, Robert, Thibodeaux, Harold, Palmer, James T, van Lookeren Campagne, Menno, Van Bruggen, Nick

“…Rodents have been extensively used for experimental stroke research with rat and gerbil the preferred species. With the advent of transgenesis and gene…”
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Apparent diffusion coefficient and MR relaxation during osmotic manipulation in isolated turtle cerebellum by O'Shea, Jacqueline M., Williams, Stephen R., van Bruggen, Nick, Gardner-Medwin, Anthony R.

“…The apparent diffusion coefficient (ADC) and relaxation times of water were measured by magnetic resonance imaging (MRI) in the isolated turtle cerebellum…”
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A Model for Quantification of Perfusion in Pulsed Labelling Techniques by Calamante, Fernando, Williams, Stephen R., van Bruggen, Nick, Kwong, Ken K., Turner, Robert

“…A model for quantification of perfusion in pulsed labelling techniques is described, based on solving the modified Bloch equation including the effects of…”
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