Search Results - "van't Veer, LJ"
-
1
Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial
Published in JNCI : Journal of the National Cancer Institute (2017)“…Ongoing controversy over the optimal approach to breast cancer screening has led to discordant professional society recommendations, particularly in women age…”
Get full text
Journal Article -
2
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Published in JAMA oncology (01-11-2017)“…The frequency of cancers with indolent behavior has increased with screening. Better tools to identify indolent tumors are needed to avoid overtreatment. To…”
Get more information
Journal Article -
3
-
4
Refinement of breast cancer classification by molecular characterization of histological special types
Published in The Journal of pathology (01-10-2008)“…Most invasive breast cancers are classified as invasive ductal carcinoma not otherwise specified (IDC NOS), whereas about 25% are defined as histological…”
Get full text
Journal Article -
5
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Published in Nature genetics (01-04-2013)“…Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls,…”
Get full text
Journal Article -
6
Breast cancer metastasis: markers and models
Published in Nature reviews. Cancer (01-08-2005)“…Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant organs. At primary diagnosis, prognostic markers are used to…”
Get full text
Journal Article -
7
Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer
Published in JNCI : Journal of the National Cancer Institute (01-07-2018)“…Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors…”
Get full text
Journal Article -
8
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival
Published in Journal of clinical oncology (01-04-2023)“…A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS ) is associated with risk of breast cancer and contralateral breast cancer. This…”
Get full text
Journal Article -
9
CHEK21100delC Heterozygosity in Women With Breast Cancer Associated With Early Death, Breast Cancer–Specific Death, and Increased Risk of a Second Breast Cancer
Published in Journal of clinical oncology (10-12-2012)“…We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific death, and risk of a…”
Get full text
Journal Article -
10
PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2
Published in British journal of cancer (21-08-2012)“…Background: Predict ( www.predict.nhs.uk ) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the…”
Get full text
Journal Article -
11
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Published in Nature communications (23-09-2014)“…GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50…”
Get full text
Journal Article -
12
Robustness, Scalability, and Integration of a Wound-Response Gene Expression Signature in Predicting Breast Cancer Survival
Published in Proceedings of the National Academy of Sciences - PNAS (08-03-2005)“…Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously…”
Get full text
Journal Article -
13
Prediction and clinical utility of a contralateral breast cancer risk model
Published in Breast cancer research : BCR (17-12-2019)“…Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable…”
Get full text
Journal Article -
14
A common coding variant in CASP8 is associated with breast cancer risk
Published in Nature genetics (01-03-2007)“…The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to…”
Get full text
Journal Article -
15
Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1
Published in American journal of human genetics (05-12-2013)“…The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association…”
Get full text
Journal Article -
16
Body mass index and breast cancer survival: a Mendelian randomization analysis
Published in International journal of epidemiology (01-12-2017)“…There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying…”
Get full text
Journal Article -
17
A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer
Published in Breast cancer research and treatment (01-02-2022)“…Purpose The Breast Cancer Surveillance Consortium (BCSC) model is a widely used risk model that predicts 5- and 10-year risk of developing invasive breast…”
Get full text
Journal Article -
18
Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts
Published in Breast cancer research and treatment (01-06-2020)“…Background Three tools are currently available to predict the risk of contralateral breast cancer (CBC). We aimed to compare the performance of the Manchester…”
Get full text
Journal Article -
19
Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
Published in Cancer research (Chicago, Ill.) (15-10-2005)“…Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of…”
Get full text
Journal Article -
20
Gene expression profiling predicts clinical outcome of breast cancer
Published in Nature (London) (31-01-2002)“…Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for…”
Get full text
Journal Article