Search Results - "van't Hof, Rob J"

Nitric oxide and bone by Van'T Hof, Rob J., Ralston, Stuart H.

“…Summary Nitric oxide (NO) is a free radical which has important effects on bone cell function. The endothelial isoform of nitric oxide synthase (eNOS) is…”
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Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice by Alonso, Nerea, Wani, Sachin, Rose, Lorraine, van't Hof, Rob J., Ralston, Stuart H., Albagha, Omar M.E.

“…ABSTRACT Early onset familial Paget's disease of bone (EoPDB), familial expansile osteolysis, and expansile skeletal hyperphosphatasia are related disorders…”
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Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro by Idris, Aymen I., Rojas, Javier, Greig, Iain R., van’t Hof, Rob J., Ralston, Stuart H.

“…Bisphosphonates are widely used for the treatment of bone diseases associated with increased osteoclastic bone resorption. Bisphosphonates are known to inhibit…”
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Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro by Bakker, Astrid D., Huesa, Carmen, Hughes, Alun, Aspden, Richard M., van’t Hof, Rob J., Klein-Nulend, Jenneke, Helfrich, Miep H.

“…Endothelial nitric oxide synthase (eNOS) has long been held responsible for NO production by mechanically stimulated osteoblasts, but this has recently been…”
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Open source software for semi-automated histomorphometry of bone resorption and formation parameters by van't Hof, Rob J, Rose, Lorraine, Bassonga, Euphemie, Daroszewska, Anna

“…Abstract Micro-CT analysis has become the standard method for assessing bone volume and architecture in small animals. However, micro-CT does not allow the…”
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The Biphenyl-Carboxylate Derivative ABD328 is a Novel Orally Active Antiresorptive Agent by Idris, Aymen I., Coste, Emmanuel, Greig, Iain R., Ralston, Stuart H., van’t Hof, Rob J.

“…We previously described a novel series of biphenyl carboxylic acid derivatives which have potent antiresorptive effects in vitro and in vivo and do not affect…”
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Discovery of biphenylketones as dual modulators of inflammation and bone loss by Greig, Iain R., Coste, Emmanuel, Ralston, Stuart H., van’t Hof, Rob J.

“…Biphenylketones were identified as novel inhibitors of NFκB activation. Structure–activity studies led to the identification of compound 4c, which had good…”
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microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity by Hayman, Dan J., Johnson de Sousa Brito, Francesca M., Lin, Hua, Prior, Amanda, Charlesworth, Gemma, Hao, Yao, Pearson, Rachel D., Soul, Jamie, Clark, Ian M., Piróg, Katarzyna A., Barter, Matt J., van't Hof, Rob J., Young, David A.

“…MicroRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each miRNA to play key roles in many…”
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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology by Huesa, Carmen, Ortiz, Ana C, Dunning, Lynette, McGavin, Laura, Bennett, Louise, McIntosh, Kathryn, Crilly, Anne, Kurowska-Stolarska, Mariola, Plevin, Robin, van 't Hof, Rob J, Rowan, Andrew D, McInnes, Iain B, Goodyear, Carl S, Lockhart, John C, Ferrell, William R

“…Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway…”
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Promoter and intron 1 polymorphisms of COL1A1 interact to regulate transcription and susceptibility to osteoporosis by Jin, Huilin, van't Hof, Rob J., Albagha, Omar M.E., Ralston, Stuart H.

“…Three polymorphisms (−1997G/T; −1663IndelT and +1245G/T) have been identified in the 5′ flank of COL1A1 gene that are associated with osteoporosis but the…”
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Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice by Bloom, Anja C, Collins, Fraser L, van't Hof, Rob J, Ryan, Elizabeth S, Jones, Emma, Hughes, Timothy R, Morgan, B. Paul, Erlandsson, Malin, Bokarewa, Maria, Aeschlimann, Daniel, Evans, Bronwen A.J, Williams, Anwen S

“…Abstract Degenerative joint diseases such as osteoarthritis are characterised by aberrant region-specific bone formation and abnormal bone mineral content. A…”
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Osteoarthritic versus osteoporotic bone and intra-skeletal variations in normal bone: Evaluation with µCT and bone histomorphometry by Zupan, Janja, van't Hof, Rob J., Vindišar, Franci, Haring, Gregor, Trebše, Rihard, Komadina, Radko, Marc, Janja

“…Several studies have shown that in contrast to osteoporosis (OP), osteoarthritis (OA) is characterized by high bone mineral density (BMD). Bone strength not…”
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The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action by Idris, Aymen I., Ralston, Stuart H., van't Hof, Rob J.

“…We have previously shown that the nitrosylated flurbiprofen derivative HCT1026 inhibits bone resorption, both in vivo and in vitro, and that its mechanism of…”
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Development and Characterization of Biphenylsulfonamides as Novel Inhibitors of Bone Resorption by Greig, Iain R, Idris, Aymen I, Ralston, Stuart H, van't Hof, Rob J

“…Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used…”
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Identification of Biphenylcarboxylic Acid Derivatives as a Novel Class of Bone Resorption Inhibitors by van 't Hof, Rob J, Idris, Aymen I, Ridge, Susan A, Dunford, James, Greig, Iain R, Ralston, Stuart H

“…A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and…”
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The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis by Beekman, Kerensa M., Veldhuis-Vlug, Annegreet G., den Heijer, Martin, Maas, Mario, Oleksik, Ania M., Tanck, Michael W., Ott, Susan M., van 't Hof, Rob J., Lips, Paul, Bisschop, Peter H., Bravenboer, Nathalie

“…In patients with postmenopausal osteoporosis low bone volume is associated with high bone marrow adipose tissue (MAT). Moreover, high MAT is associated with…”
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Low protein intake during reproduction compromises the recovery of lactation‐induced bone loss in female mouse dams without affecting skeletal muscles by Kanakis, Ioannis, Alameddine, Moussira, Scalabrin, Mattia, ‘t Hof, Rob J., Liloglou, Triantafillos, Ozanne, Susan E., Goljanek‐Whysall, Katarzyna, Vasilaki, Aphrodite

“…Lactation‐induced bone loss occurs due to high calcium requirements for fetal growth but skeletal recovery is normally achieved promptly postweaning. Dietary…”
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Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis by Kanakis, Ioannis, Liu, Ke, Poulet, Blandine, Javaheri, Behzad, Hof, Rob J., Pitsillides, Andrew A., Bou‐Gharios, George

“…Objective Cartilage destruction in osteoarthritis (OA) is mediated mainly by matrix metalloproteinases (MMPs) and ADAMTS. The therapeutic candidature of…”
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity by Loveridge, Carolyn J., van ’t Hof, Rob J., Charlesworth, Gemma, King, Ayala, Tan, Ee Hong, Rose, Lorraine, Daroszewska, Anna, Prior, Amanda, Ahmad, Imran, Welsh, Michelle, Mui, Ernest J., Ford, Catriona, Salji, Mark, Sansom, Owen, Blyth, Karen, Leung, Hing Y.

“…Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1 -mediated Cre expression is a useful…”
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The essential requirement for Runx1 in the development of the sternum by Liakhovitskaia, Anna, Lana-Elola, Eva, Stamateris, Evangelos, Rice, David P., van 't Hof, Rob J., Medvinsky, Alexander

“…Runx1 is highly expressed in chondroprogenitor and osteoprogenitor cells and in vitro experiments suggest that Runx1 is important in the early stages of…”
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