Search Results - "thor Straten, Per"

Exercise and cancer: from “healthy” to “therapeutic”? by Idorn, Manja, thor Straten, Per

“…Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely…”
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Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution by Pedersen, Line, Idorn, Manja, Olofsson, Gitte H., Lauenborg, Britt, Nookaew, Intawat, Hansen, Rasmus Hvass, Johannesen, Helle Hjorth, Becker, Jürgen C., Pedersen, Katrine S., Dethlefsen, Christine, Nielsen, Jens, Gehl, Julie, Pedersen, Bente K., thor Straten, Per, Hojman, Pernille

“…Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study,…”
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TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting by Peeters, Marlies J. W., Rahbech, Anne, thor Straten, Per

“…The TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) or…”
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Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations by Rius, Cristina, Attaf, Meriem, Tungatt, Katie, Bianchi, Valentina, Legut, Mateusz, Bovay, Amandine, Donia, Marco, Thor Straten, Per, Peakman, Mark, Svane, Inge Marie, Ott, Sascha, Connor, Tom, Szomolay, Barbara, Dolton, Garry, Sewell, Andrew K

“…Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers, have transformed the study of Ag-specific T cells by allowing direct detection,…”
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Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo by Holmen Olofsson, Gitte, Jensen, Agnete Witness Praest, Idorn, Manja, Thor Straten, Per

“…Recent advances in clinical oncology is based on exploiting the capacity of the immune system to combat cancer: immuno-oncology. Thus, immunotherapy of cancer…”
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Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers by Schumacher, Ton N, Hadrup, Sine Reker, Bakker, Arnold H, Shu, Chengyi J, Andersen, Rikke S, van Veluw, Jerre, Hombrink, Pleun, Castermans, Emilie, thor Straten, Per, Blank, Christian, Haanen, John B, Heemskerk, Mirjam H

“…Using combinations of fluorescently labeled peptide–major histocompatability complex (pMHC) tetramers, T-cell populations with multiple antigen specificities…”
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T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors by LYNGAA, Rikke, PEDERSEN, Natasja Wulff, SCHRAMA, David, THRUE, Charlotte Albaek, IBRANI, Dafina, MET, Özcan, PER THOR STRATEN, NGHIEM, Paul, BECKER, Jürgen C, HADRUP, Sine Reker

“…Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with strong evidence of viral carcinogenesis. The association of MCC with the Merkel cell…”
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Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma[S] by Shraibman, Bracha, Barnea, Eilon, Kadosh, Dganit Melamed, Haimovich, Yael, Slobodin, Gleb, Rosner, Itzhak, López-Larrea, Carlos, Hilf, Norbert, Kuttruff, Sabrina, Song, Colette, Britten, Cedrik, Castle, John, Kreiter, Sebastian, Frenzel, Katrin, Tatagiba, Marcos, Tabatabai, Ghazaleh, Dietrich, Pierre-Yves, Dutoit, Valérie, Wick, Wolfgang, Platten, Michael, Winkler, Frank, von Deimling, Andreas, Kroep, Judith, Sahuquillo, Juan, Martinez-Ricarte, Francisco, Rodon, Jordi, Lassen, Ulrik, Ottensmeier, Christian, van der Burg, Sjoerd H., Thor Straten, Per, Poulsen, Hans Skovgaard, Ponsati, Berta, Okada, Hideho, Rammensee, Hans-Georg, Sahin, Ugur, Singh, Harpreet, Admon, Arie

“…Glioblastoma is an aggressive brain tumor, thus early detection and immunotherapy may improve survival. This study includes large-scale analyses of the…”
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Chemokine Receptors and Exercise to Tackle the Inadequacy of T Cell Homing to the Tumor Site by Idorn, Manja, Thor Straten, Per

“…While cancer immune therapy has revolutionized the treatment of metastatic disease across a wide range of cancer diagnoses, a major limiting factor remains…”
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Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model by Idorn, Manja, Skadborg, Signe Koggersbøl, Kellermann, Lauge, Halldórsdóttir, Hólmfrídur Rósa, Holmen Olofsson, Gitte, Met, Özcan, thor Straten, Per

“…Adoptive cell therapy (ACT) using in vitro expanded tumor infiltrating T lymphocytes (TILs) from biopsy material represents a highly promising treatment of…”
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High Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)-a randomized controlled trial by Holmen Olofsson, Gitte, Mikkelsen, Marta Kramer, Ragle, Anne-Mette, Christiansen, Anne Birgitte, Olsen, Anne Pries, Heide-Ottosen, Lise, Horsted, Cecilia Bech, Pedersen, Cia Moon Scharbau, Engell-Noerregaard, Lotte, Lorentzen, Torben, Persson, Gitte Fredberg, Vinther, Anders, Nielsen, Dorte Lisbet, Thor Straten, Per

“…The increasing role of exercise training in cancer care is built on evidence that exercise can reduce side effects of treatment, improve physical functioning…”
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Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling by Donia, Marco, Harbst, Katja, van Buuren, Marit, Kvistborg, Pia, Lindberg, Mattias F, Andersen, Rikke, Idorn, Manja, Munir Ahmad, Shamaila, Ellebæk, Eva, Mueller, Anja, Fagone, Paolo, Nicoletti, Ferdinando, Libra, Massimo, Lauss, Martin, Hadrup, Sine Reker, Schmidt, Henrik, Andersen, Mads Hald, Thor Straten, Per, Nilsson, Jonas A, Schumacher, Ton N, Seliger, Barbara, Jönsson, Göran, Svane, Inge Marie

“…Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression…”
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Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients by Ellebaek, Eva, Iversen, Trine Zeeberg, Junker, Niels, Donia, Marco, Engell-Noerregaard, Lotte, Met, Özcan, Hölmich, Lisbet Rosenkrantz, Andersen, Rikke Sick, Hadrup, Sine Reker, Andersen, Mads Hald, thor Straten, Per, Svane, Inge Marie

“…Adoptive cell therapy may be based on isolation of tumor-specific T cells, e.g. autologous tumor infiltrating lymphocytes (TIL), in vitro activation and…”
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Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells by Glöckner, Hannah Jorinde, Martinenaite, Evelina, Landkildehus Lisle, Thomas, Grauslund, Jacob, Ahmad, Shamaila, Met, Özcan, Thor Straten, Per, Hald Andersen, Mads

“…Arginase-1 (Arg1) is expressed by regulatory myeloid cells in the tumor microenvironment (TME), where they play a pro-tumorigenic and T-cell suppressive role…”
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The Universal Character of the Tumor-Associated Antigen Survivin by HALD ANDERSEN, Mads, MARIE SVANE, Inge, BECKER, Jurgen C, THOR STRATEN, Per

“…Survivin is expressed in most human neoplasms, but is absent in normal, differentiated tissues. Survivin is a bifunctional inhibitor of apoptosis protein that…”
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Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B by SKOV, Søren, PEDERSEN, Marianne Terndrup, ANDRESEN, Lars, STRATEN, Per Thor, WOETMANN, Anders, ØDUM, Niels

“…We show that histone deacetylase (HDAC) inhibitors lead to functional expression of MHC class I-related chain A and B (MICA/B) on cancer cells, making them…”
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Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial by Schuhmacher, Juliane, Heidu, Sonja, Balchen, Torben, Richardson, Jennifer Rebecca, Schmeltz, Camilla, Sonne, Jesper, Schweiker, Jonas, Rammensee, Hans-Georg, Thor Straten, Per, Røder, Martin Andreas, Brasso, Klaus, Gouttefangeas, Cécile

“…BackgroundPeptide-based vaccination is a rational option for immunotherapy of prostate cancer. In this first-in-man phase I/II study, we assessed the safety,…”
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Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction by Idorn, Manja, Olsen, Maria, Halldórsdóttir, Hólmfrídur Rósa, Skadborg, Signe Koggersbøl, Pedersen, Magnus, Høgdall, Claus, Høgdall, Estrid, Met, Özcan, thor Straten, Per

“…Chemokines are essential mediators of cellular trafficking, interactions and tumor development. Though adoptive cell therapy (ACT) has been a tremendous…”
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Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression by Carnaz Simões, Ana Micaela, Holmström, Morten Orebo, Aehnlich, Pia, Rahbech, Anne, Radziwon-Balicka, Aneta, Zamora, Carlos, Wirenfeldt Klausen, Tobias, Skov, Vibe, Kjær, Lasse, Ellervik, Christina, Fassi, Daniel El, Vidal, Silvia, Hasselbalch, Hans Carl, Andersen, Mads Hald, Thor Straten, Per

“…Myeloproliferative neoplasms (MPN) are chronic cancers of the hematopoietic stem cells in the bone marrow, and patients often harbor elevated numbers of…”
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Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase by Munir, Shamaila, Larsen, Stine Kiaer, Iversen, Trine Zeeberg, Donia, Marco, Klausen, Tobias Wirenfeldt, Svane, Inge Marie, Straten, Per Thor, Andersen, Mads Hald

“…The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as…”
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