Search Results - "ten Hoeve, Jelle"

MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing by FARAZI, Thalia A, HORLINGS, Hugo M, KREIKE, Bas, SIE, Daoud, HOVESTADT, Volker, WESSELS, Lodewyk F. A, VAN DE VIJVER, Marc J, TUSCHL, Thomas, TEN HOEVE, Jelle J, MIHAILOVIC, Aleksandra, HALFWERK, Hans, MOROZOV, Pavel, BROWN, Miguel, HAFNER, Markus, REYAL, Fabien, VAN KOUWENHOVE, Marieke

“…MicroRNAs (miRNA) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 noninvasive, 151 invasive breast…”
Get full text

Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients by de Jong, Monique C, Ten Hoeve, Jelle J, Grénman, Reidar, Wessels, Lodewyk F, Kerkhoven, Ron, Te Riele, Hein, van den Brekel, Michiel W M, Verheij, Marcel, Begg, Adrian C

“…Predominant causes of head and neck cancer recurrence after radiotherapy are rapid repopulation, hypoxia, fraction of cancer stem cells, and intrinsic…”
Get full text

Using TRIP for genome-wide position effect analysis in cultured cells by Akhtar, Waseem, Pindyurin, Alexey V, de Jong, Johann, Pagie, Ludo, ten Hoeve, Jelle, Berns, Anton, Wessels, Lodewyk F A, van Steensel, Bas, van Lohuizen, Maarten

“…A detailed protocol for analyzing thousands of reporters integrated in parallel (TRIP) at a genome-wide level to study the influence of local chromatin context…”
Get full text

Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets by Farazi, Thalia A, Ten Hoeve, Jelle J, Brown, Miguel, Mihailovic, Aleksandra, Horlings, Hugo M, van de Vijver, Marc J, Tuschl, Thomas, Wessels, Lodewyk F A

“…Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this…”
Get full text

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis by March, H Nikki, Rust, Alistair G, Wright, Nicholas A, ten Hoeve, Jelle, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J, Wessels, Lodewyk F A, Winton, Douglas J, Adams, David J

“…Douglas Winton and colleagues report the results of a large insertional mutagenesis screen to identify drivers of intestinal tumorigenesis in mice. The study…”
Get full text

Validation of a clinical blood-based decision aid to guide immunotherapy treatment in patients with non-small cell lung cancer by Muller, Mirte, Hoogendoorn, Roland, Moritz, Ruben J.G., van der Noort, Vincent, Lanfermeijer, Mirthe, Korse, Catharina M., van den Broek, Daan, ten Hoeve, Jelle J., Baas, Paul, van Rossum, Huub H., van den Heuvel, Michel M.

“…BACKGROUND: The widespread introduction of immunotherapy in patients with advanced non-small cell lung cancer (NSCLC) has led to durable responses but still…”
Get full text

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance by Ikink, Gerjon J., Boer, Mandy, Bakker, Elvira R. M., Vendel-Zwaagstra, Annabel, Klijn, Chris, ten Hoeve, Jelle, Jonkers, Jos, Wessels, Lodewyk F., Hilkens, John

“…Personalized medicine for cancer patients requires a deep understanding of the underlying genetics that drive cancer and the subsequent identification of…”
Get full text

Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing by Farazi, Thalia A., Brown, Miguel, Morozov, Pavel, ten Hoeve, Jelle J., Ben-Dov, Iddo Z., Hovestadt, Volker, Hafner, Markus, Renwick, Neil, Mihailović, Aleksandra, Wessels, Lodewyk F.A., Tuschl, Thomas

“…The characterization of post-transcriptional gene regulation by small regulatory RNAs of 20–30 nt length, particularly miRNAs and piRNAs, has become a major…”
Get full text

Erratum to: Validation of a clinical blood-based decision aid to guide immunotherapy treatment in patients with non-small cell lung cancer by Muller, Mirte, Hoogendoorn, Roland, Moritz, Ruben J.G., van der Noort, Vincent, Lanfermeijer, Mirthe, Korse, Catharina M., van den Broek, Daan, ten Hoeve, Jelle J., Baas, Paul, van Rossum, Huub H., van den Heuvel, Michel M.

Get full text

RUBIC identifies driver genes by detecting recurrent DNA copy number breaks by van Dyk, Ewald, Hoogstraat, Marlous, ten Hoeve, Jelle, Reinders, Marcel J. T., Wessels, Lodewyk F. A.

“…The frequent recurrence of copy number aberrations across tumour samples is a reliable hallmark of certain cancer driver genes. However, state-of-the-art…”
Get full text

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma by Kas, Sjors M, de Ruiter, Julian R, Schipper, Koen, Annunziato, Stefano, Schut, Eva, Klarenbeek, Sjoerd, Drenth, Anne Paulien, van der Burg, Eline, Klijn, Christiaan, ten Hoeve, Jelle J, Adams, David J, Koudijs, Marco J, Wesseling, Jelle, Nethe, Micha, Wessels, Lodewyk F A, Jonkers, Jos

“…Jos Jonkers, Lodewyk Wessels and colleagues use a Sleeping Beauty transposon mutagenesis screen to identify genes required for invasive lobular breast…”
Get full text

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors by Koudijs, Marco J, Klijn, Christiaan, van der Weyden, Louise, Kool, Jaap, ten Hoeve, Jelle, Sie, Daoud, Prasetyanti, Pramudita R, Schut, Eva, Kas, Sjors, Whipp, Theodore, Cuppen, Edwin, Wessels, Lodewyk, Adams, David J, Jonkers, Jos

“…Retroviral and transposon-based insertional mutagenesis (IM) screens are widely used for cancer gene discovery in mice. Exploiting the full potential of IM…”
Get full text

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors by Klijn, Christiaan, Koudijs, Marco J, Kool, Jaap, ten Hoeve, Jelle, Boer, Mandy, de Moes, Joost, Akhtar, Waseem, van Miltenburg, Martine, Vendel-Zwaagstra, Annabel, Reinders, Marcel J T, Adams, David J, van Lohuizen, Maarten, Hilkens, John, Wessels, Lodewyk F A, Jonkers, Jos

“…Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the…”
Get full text

Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment by Rigter, Lisanne S, Snaebjornsson, Petur, Rosenberg, Efraim H, Atmodimedjo, Peggy N, Aleman, Berthe M, Ten Hoeve, Jelle, Geurts-Giele, Willemina R, van Ravesteyn, Thomas W, Hoeksel, Johan, Meijer, Gerrit A, Te Riele, Hein, van Leeuwen, Flora E, Dinjens, Winand N, van Leerdam, Monique E

“…Hodgkin's lymphoma survivors who were treated with infradiaphragmatic radiotherapy or procarbazine-containing chemotherapy have a fivefold increased risk of…”
Get more information

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer by Rad, Roland, Rad, Lena, Wang, Wei, Strong, Alexander, Ponstingl, Hannes, Bronner, Iraad F, Mayho, Matthew, Steiger, Katja, Weber, Julia, Hieber, Maren, Veltkamp, Christian, Eser, Stefan, Geumann, Ulf, Öllinger, Rupert, Zukowska, Magdalena, Barenboim, Maxim, Maresch, Roman, Cadiñanos, Juan, Friedrich, Mathias, Varela, Ignacio, Constantino-Casas, Fernando, Sarver, Aaron, ten Hoeve, Jelle, Prosser, Haydn, Seidler, Barbara, Bauer, Judith, Heikenwälder, Mathias, Metzakopian, Emmanouil, Krug, Anne, Ehmer, Ursula, Schneider, Günter, Knösel, Thomas, Rümmele, Petra, Aust, Daniela, Grützmann, Robert, Pilarsky, Christian, Ning, Zemin, Wessels, Lodewyk, Schmid, Roland M, Quail, Michael A, Vassiliou, George, Esposito, Irene, Liu, Pentao, Saur, Dieter, Bradley, Allan

“…Roland Rad and colleagues report development of a new conditional piggyBac transposition system for performing insertional mutagenesis screens in mice. They…”
Get full text

Corrigendum: using TRIP for genome-wide position effect analysis in cultured cells by Akhtar, Waseem, Pindyurin, Alexey V, de Jong, Johann, Pagie, Ludo, Ten Hoeve, Jelle, Berns, Anton, Wessels, Lodewyk F A, van Steensel, Bas, van Lohuizen, Maarten

Get full text

Erratum: Corrigendum: Using TRIP for genome-wide position effect analysis in cultured cells by Akhtar, Waseem, Pindyurin, Alexey V, de Jong, Johann, Pagie, Ludo, ten Hoeve, Jelle, Berns, Anton, Wessels, Lodewyk F A, van Steensel, Bas, van Lohuizen, Maarten

Get full text

Correction: Corrigendum: Using TRIP for genome-wide position effect analysis in cultured cells by Akhtar, Waseem, Pindyurin, Alexey V, de Jong, Johann, Pagie, Ludo, ten Hoeve, Jelle, Berns, Anton, Wessels, Lodewyk F A, van Steensel, Bas, van Lohuizen, Maarten

“…Nat. Protoc. 9, 1255–1281 (2014); doi:10.1038/nprot.2014.072; published online 8 May 2014; corrected after print 16 January 2015 In the version of this article…”
Get full text

AACR Project GENIE: Powering Precision Medicine through an International Consortium

“…The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating…”
Get more information

Optimizing sharing of hospital biobank samples by Riegman, Peter H J, de Jong, Bas, Daidone, Maria Grazia, Söderström, Tommy, Thompson, James, Hall, Jacqueline A, Mendy, Maimuna, Ten Hoeve, Jelle, Broeks, Annegien, Reed, Wenche, Morente, Manuel M, López-Guerrero, José Antonio, Collins, V Peter, Rogan, Jane, Ringborg, Ulrik

“…Implementing technical guidelines and standards as well as ways to boost cooperation should facilitate sharing of hospital biobank samples…”
Get more information