Search Results - "ten Hacken, Nick H. T."

AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers by Faiz, Alen, van den Berge, Maarten, Vermeulen, Cornelis J, Ten Hacken, Nick H T, Guryev, Victor, Pouwels, Simon D

“…Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor…”
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Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung by Dijkstra, Antoon, Postma, Dirkje S., Noordhoek, Jacobien A., Lodewijk, Monique E., Kauffman, Henk F., ten Hacken, Nick H. T., Timens, Wim

“…In view of the associations of “a disintegrin and metalloprotease” (ADAM) with respiratory diseases, we assessed the expression of various ADAMs in human lung…”
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Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review by van der Wiel, Erica, MD, ten Hacken, Nick H.T., MD, PhD, Postma, Dirkje S., MD, PhD, van den Berge, Maarten, MD, PhD

“…Traditionally, asthma has been considered a disease that predominantly involves the large airways. Today, this concept is being challenged, and increasing…”
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Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma by Cox, Claire A, Boudewijn, Ilse M, Vroegop, Sebastiaan J, Schokker, Siebrig, Lexmond, Anne J, Frijlink, Henderik W, Hagedoorn, Paul, Vonk, Judith M, Farenhorst, Martijn P, Ten Hacken, Nick H T, Kerstjens, Huib A M, van den Berge, Maarten

“…Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV . Provocation tests only use…”
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Affimers as an Alternative to Antibodies in an Affinity LC–MS Assay for Quantification of the Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Human Serum by Klont, Frank, Hadderingh, Marrit, Horvatovich, Péter, ten Hacken, Nick H. T, Bischoff, Rainer

“…Antibodies are indispensable tools in biomedical research, but their size, complexity, and sometimes lack of reproducibility created a need for the development…”
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Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls by Kruk, Dennis, Yeung, Anna C Y, Faiz, Alen, Ten Hacken, Nick H T, Timens, Wim, van Kuppevelt, Toin H, Daamen, Willeke, Hof, Danique, Harmsen, Martin C, Rojas, Mauricio, Heijink, Irene H

“…Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured…”
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Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans by Klont, Frank, Horvatovich, Peter, Bowler, Russell P, van Rikxoort, Eva, Charbonnier, Jean-Paul, Kwiatkowski, Marcel, Lynch, David A, Humphries, Stephen, Bischoff, Rainer, Ten Hacken, Nick H T, Pouwels, Simon D

“…There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE…”
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Treatment of bronchiectasis in adults by Hacken, Nick H T ten, Wijkstra, Peter J, Kerstjens, Huib A M

“…A study of 150 adults with bronchiectasis in the UK found that 53% of cases were idiopathic; 29% were post-infectious; 8% were caused by an immune defect, 7%…”
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The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils by Wiersma, Valerie R., Hoonhorst, Susan J. M., ten Hacken, Nick H. T., van den Berge, Maarten, Slebos, Dirk-Jan, Pouwels, Simon D.

“…The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and…”
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Advanced glycation endproducts and their receptor in different body compartments in COPD by Hoonhorst, Susan J M, Lo Tam Loi, Adèle T, Pouwels, Simon D, Faiz, Alen, Telenga, Eef D, van den Berge, Maarten, Koenderman, Leo, Lammers, Jan-Willem J, Boezen, H Marike, van Oosterhout, Antoon J M, Lodewijk, Monique E, Timens, Wim, Postma, Dirkje S, Ten Hacken, Nick H T

“…Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by chronic airway inflammation and emphysema, and is caused by exposure to…”
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CT-Based Local Distribution Metric Improves Characterization of COPD by Hoff, Benjamin A., Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S., Lammers, Jan-Willem J., ten Hacken, Nick H. T., Koenderman, Leo, Johnson, Timothy D., Verleden, Stijn E., de Jong, Pim A., Mohamed Hoesein, Firdaus A. A., van den Berge, Maarten, Ross, Brian D., Galbán, Craig J.

“…Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and…”
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Comparison of Multiple Diagnostic Tests to Measure Dynamic Hyperinflation in Patients with Severe Emphysema Treated with Endobronchial Coils by van Dijk, Marlies, Hartman, Jorine E., Augustijn, Sonja W. S., ten Hacken, Nick H. T., Klooster, Karin, Slebos, Dirk-Jan

“…Purpose For this study, we aimed to compare dynamic hyperinflation measured by cardiopulmonary exercise testing (CPET), a six-minute walking test (6-MWT), and…”
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Change in Dynamic Hyperinflation After Bronchoscopic Lung Volume Reduction in Patients with Emphysema by van Dijk, Marlies, Klooster, Karin, Hartman, Jorine E., ten Hacken, Nick H. T., Slebos, Dirk-Jan

“…Background and Purpose In patients with severe emphysema, dynamic hyperinflation is superimposed on top of already existing static hyperinflation. Static…”
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Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression by Boudewijn, Ilse M, Faiz, Alen, Steiling, Katrina, van der Wiel, Erica, Telenga, Eef D, Hoonhorst, Susan J M, Ten Hacken, Nick H T, Brandsma, Corry-Anke, Kerstjens, Huib A M, Timens, Wim, Heijink, Irene H, Jonker, Marnix R, de Bruin, Harold G, Sebastiaan Vroegop, J, Pasma, Henk R, Boersma, Wim G, Wielders, Pascal, van den Elshout, Frank, Mansour, Khaled, Spira, Avrum, Lenburg, Marc E, Guryev, Victor, Postma, Dirkje S, van den Berge, Maarten

“…Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish…”
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Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease: A Randomized Trial by LAPPERRE, Thérèse S, SNOECK-STROBAND, Jiska B, RABE, Klaus F, KERSTJENS, Huib A. M, HIEMSTRA, Pieter S, TIMENS, Wim, POSTMA, Dirkje S, STERK, Peter J, GOSMAN, Margot M. E, JANSEN, Désirée F, VAN SCHADEWIJK, Annemarie, THIADENS, Henk A, VONK, Judith M, MARIKE BOEZEN, H, TEN HACKEN, Nick H. T, SONT, Jacob K

“…Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD). To…”
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Susceptibility to COPD: differential proteomic profiling after acute smoking by Franciosi, Lorenza, Postma, Dirkje S, van den Berge, Maarten, Govorukhina, Natalia, Horvatovich, Peter L, Fusetti, Fabrizia, Poolman, Bert, Lodewijk, Monique E, Timens, Wim, Bischoff, Rainer, ten Hacken, Nick H T

“…Cigarette smoking is the main risk factor for COPD (Chronic Obstructive Pulmonary Disease), yet only a subset of smokers develops COPD. Family members of…”
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Persisting Remodeling and Less Airway Wall Eosinophil Activation in Complete Remission of Asthma by BROEKEMA, Martine, TIMENS, Wim, VONK, Judith M, VOLBEDA, Franke, LODEWIJK, Monique E, HYLKEMA, Machteld N, TEN HACKEN, Nick H. T, POSTMA, Dirkje S

“…Individuals with asthma may outgrow symptoms despite not using treatment, whereas others reach complete remission (CoR) with absence of airway obstruction and…”
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Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells by Kruk, Dennis M L W, Wisman, Marissa, Noordhoek, Jacobien A, Nizamoglu, Mehmet, Jonker, Marnix R, de Bruin, Harold G, Arevalo Gomez, Karla, Ten Hacken, Nick H T, Pouwels, Simon D, Heijink, Irene H

“…COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage…”
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Airway wall thickness on HRCT scans decreases with age and increases with smoking by Telenga, Eef D, Oudkerk, Matthijs, van Ooijen, Peter M A, Vliegenthart, Rozemarijn, Ten Hacken, Nick H T, Postma, Dirkje S, van den Berge, Maarten

“…To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher…”
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Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial by Snoeck-Stroband, Jiska B, Lapperre, Therese S, Sterk, Peter J, Hiemstra, Pieter S, Thiadens, Henk A, Boezen, H Marike, Ten Hacken, Nick H T, Kerstjens, Huib A M, Postma, Dirkje S, Timens, Wim, Sont, Jacob K

“…The decline in lung function can be reduced by long-term inhaled corticosteroid (ICS) treatment in subsets of patients with chronic obstructive pulmonary…”
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