Mortality Update of Workers Exposed to Acrylonitrile in the Netherlands

A retrospective cohort study investigating the cause-specific mortality patterns of 2842 workers occupationally exposed to acrylonitrile for at least 6 months before 1 July 1979 was updated. The comparison group consisted of 3961 workers from a nitrogen fixation plant during the same time interval....

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Bibliographic Details
Published in:	Scandinavian Journal of Work, Environment ＆ Health Vol. 24; no. 2; pp. 10 - 16
Main Authors:	Swaen, Gerard MH, Bloemen, Louis JN, Twisk, Jan, Scheffers, Theo, Slangen, Jos JM, Collins, James J, ten Berge, Wil FJP, Sturmans, Ferd
Format:	Journal Article
Language:	English
Published:	Finland Scandinavian Journal of Work, Environment ＆ Health 01-01-1998 National Institute for Working Life Finnish Institute of Occupational Health National Institute of Occupational Health (Denmark) National Institute of Occupational Health (Norway)
Subjects:	Acrylonitrile - adverse effects Adult Age Distribution Brain neoplasms Carcinogens Cause of Death Causes of death Cohort Studies Confidence Intervals Death Dosage Epidemiology Female Humans Incidence Industrial hygiene Leukemia Lung neoplasms Male Middle Aged Mortality Neoplasms - chemically induced Neoplasms - diagnosis Neoplasms - mortality Netherlands - epidemiology Occupational Exposure - adverse effects Occupational Exposure - statistics & numerical data Respiratory Protective Devices - utilization Retrospective Studies Risk Factors Sex Distribution Survival Rate Netherlands epidemiology occupational exposures carcinogenicity
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Summary:	A retrospective cohort study investigating the cause-specific mortality patterns of 2842 workers occupationally exposed to acrylonitrile for at least 6 months before 1 July 1979 was updated. The comparison group consisted of 3961 workers from a nitrogen fixation plant during the same time interval. Industrial hygiene assessments quantified past exposure to acrylonitrile, the use of personal protective equipment, and exposure to other potential carcinogenic agents. All 6803 workers were followed for mortality until 1 January 1996. The follow-up was almost complete (99.6%), and for 99.3% the cause of death was ascertained. Age distribution, follow-up period, and temporal changes in background mortality rates were adjusted for in calculations of standardized mortality ratios for separate causes of death. Cumulative dose-effect relations were determined for 3 exposure categories and 3 latency periods. The results showed that, although cancer mortality fluctuated slightly, no cancer excess seems related to exposure to acrylonitrile.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0355-3140 1795-990X