Search Results - "ten Berge, Wil F."
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A Generic, Cross-Chemical Predictive PBTK Model with Multiple Entry Routes Running as Application in MS Excel; Design of the Model and Comparison of Predictions with Experimental Results
Published in The Annals of occupational hygiene (01-10-2011)“…Aim: Physiologically based toxicokinetic (PBTK) models are computational tools, which simulate the absorption, distribution, metabolism, and excretion of…”
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Dermal penetration of propylene glycols: Measured absorption across human abdominal skin in vitro and comparison with a QSAR model
Published in Toxicology in vitro (01-12-2011)“…► Dermal penetration of propylene glycols measured in vitro is compared with a QSAR model. ► The measured Jss and Kp for MPG were 97.6μg/cm2/h and…”
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Estimating skin permeation. The validation of five mathematical skin permeation models
Published in Chemosphere (Oxford) (01-04-1995)“…This study provides an analysis of the reliability of five mathematical models, simulating permeation of substances through the skin from aqueous solutions. An…”
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Mortality Update of Workers Exposed to Acrylonitrile in The Netherlands
Published in Journal of occupational and environmental medicine (01-07-2004)“…To study the possible carcinogenic effects of acrylonitrile, we updated the follow up of a cohort of 2842 acrylonitrile workers. The comparison group consisted…”
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Kaplan-Meier Tumor Probability as a Starting Point for Dose-Response Modeling Provides Accurate Lifetime Risk Estimates from Rodent Carcinogenicity Studies
Published in Annals of the New York Academy of Sciences (01-01-1999)“…: In rodent carcinogenicity studies the linearized multistage model for modelling the dose‐response for specific tumor incidence has limitations in accuracy…”
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Physiologically Based Toxicokinetic Modeling of 1,3-Butadiene Lung Metabolism in Mice Becomes More Important at Low Doses
Published in Environmental health perspectives (01-11-1993)“…This paper describes a physiologically based toxicokinetic model for 1,3-butadiene uptake, distribution, and metabolic clearance in mice. Model parameters for…”
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