Search Results - "ten Brinke, Anja"

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates by Verstegen, Niels J M, Pollastro, Sabrina, Unger, Peter-Paul A, Marsman, Casper, Elias, George, Jorritsma, Tineke, Streutker, Marij, Bassler, Kevin, Haendler, Kristian, Rispens, Theo, Schultze, Joachim L, Ten Brinke, Anja, Beyer, Marc, van Ham, S Marieke

“…Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate protective humoral immunity. A detailed understanding of the cues…”
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Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells by Peyron, Ivan, Hartholt, Robin B, Pedró-Cos, Laura, van Alphen, Floris, Brinke, Anja Ten, Lardy, Neubury, Meijer, Alexander B, Voorberg, Jan

“…The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor…”
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Flow Cytometric Methods for the Detection of Intracellular Signaling Proteins and Transcription Factors Reveal Heterogeneity in Differentiating Human B Cell Subsets by Marsman, Casper, Jorritsma, Tineke, Ten Brinke, Anja, van Ham, S Marieke

“…The flow cytometric detection of intracellular (IC) signaling proteins and transcription factors (TFs) will help to elucidate the regulation of B cell…”
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Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses by Ten Brinke, Anja, Marek-Trzonkowska, Natalia, Mansilla, Maria J, Turksma, Annelies W, Piekarska, Karolina, Iwaszkiewicz-Grześ, Dorota, Passerini, Laura, Locafaro, Grazia, Puñet-Ortiz, Joan, van Ham, S Marieke, Hernandez-Fuentes, Maria P, Martínez-Cáceres, Eva M, Gregori, Silvia

“…Adoptive therapy with regulatory T cells or tolerance-inducing antigen (Ag)-presenting cells is innovative and promising therapeutic approach to control…”
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von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII by Sorvillo, Nicoletta, Hartholt, Robin B, Bloem, Esther, Sedek, Magdalena, ten Brinke, Anja, van der Zwaan, Carmen, van Alphen, Floris P, Meijer, Alexander B, Voorberg, Jan

“…It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we…”
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Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ by Hrdinová, Johana, Verbij, Fabian C, Kaijen, Paul H P, Hartholt, Robin B, van Alphen, Floris, Lardy, Neubury, Ten Brinke, Anja, Vanhoorelbeke, Karen, Hindocha, Pooja J, De Groot, Anne S, Meijer, Alexander B, Voorberg, Jan, Peyron, Ivan

“…Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra…”
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Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort by Van Ham, S. Marieke, Martinez-Caceres, Eva M., Trzonkowski, Piotr, Lord, Phillip, Lombardi, Giovanna, Hutchinson, James A., Geissler, Edward K., Cools, Nathalie, Hilkens, Catharien M. U., Ten Brinke, Anja, Sawitzki, B.

“…The number of patients with autoimmune diseases and severe allergies and recipients of transplants increases worldwide. Currently, these patients require…”
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Longitudinal SARS-CoV-2 humoral response in MS patients with and without SARS-CoV-2 infection prior to vaccination by van Dam, Koos P. J., Hogenboom, Laura, Stalman, Eileen W., Kummer, Laura Y. L., Steenhuis, Maurice, Keijser, Jim B. D., Brinke, Anja ten, van Ham, S. Marieke, Kuijpers, Taco W., Rispens, Theo, Wieske, Luuk, Eftimov, Filip, Strijbis, Eva M., Killestein, Joep, van Kempen, Zoé L. E.

“…IntroductionDuring the COVID-19 pandemic, certain disease modifying therapies (DMTs) used in multiple sclerosis (MS), such as anti-CD20 therapies, have been…”
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Phenotypic and Functional Characterization of Circulating Polyomavirus BK VP1-Specific CD8+ T Cells in Healthy Adults by van Aalderen, Michiel C, Remmerswaal, Ester B M, Heutinck, Kirstin M, ten Brinke, Anja, Pircher, Hanspeter, van Lier, René A W, ten Berge, Ineke J M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells by van Aalderen, Michiel C, Remmerswaal, Ester B M, Heutinck, Kirstin M, Ten Brinke, Anja, Feltkamp, Mariet C W, van der Weerd, Neelke C, van der Pant, Karlijn A M I, Bemelman, Frederike J, van Lier, René A W, Ten Berge, Ineke J M

“…Polyomavirus BK (BKPyV) frequently reactivates in immunosuppressed renal transplant recipients (RTRs) and may lead to graft loss due to BKPyV-induced…”
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Anaphylatoxin C5a Regulates 6-Sulfo-LacNAc Dendritic Cell Function in Human through Crosstalk with Toll-Like Receptor-Induced CREB Signaling by Zaal, Anouk, Dieker, Miranda, Oudenampsen, Manon, Turksma, Annelies W, Lissenberg-Thunnissen, Suzanne N, Wouters, Diana, van Ham, S Marieke, Ten Brinke, Anja

“…Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early events in the immune defense against invading pathogens…”
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A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation by Paul, Petra, van den Hoorn, Tineke, Jongsma, Marlieke L.M., Bakker, Mark J., Hengeveld, Rutger, Janssen, Lennert, Cresswell, Peter, Egan, David A., van Ham, Marieke, ten Brinke, Anja, Ovaa, Huib, Beijersbergen, Roderick L., Kuijl, Coenraad, Neefjes, Jacques

“…MHC class II molecules (MHC-II) present peptides to T helper cells to facilitate immune responses and are strongly linked to autoimmune diseases. To unravel…”
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Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients by Oja, Anna E., Saris, Anno, Ghandour, Cherien A., Kragten, Natasja A.M., Hogema, Boris M., Nossent, Esther J., Heunks, Leo M.A., Cuvalay, Susan, Slot, Ed, Linty, Federica, Swaneveld, Francis H., Vrielink, Hans, Vidarsson, Gestur, Rispens, Theo, Schoot, Ellen, Lier, René A.W., Ten Brinke, Anja, Hombrink, Pleun

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding…”
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Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells by Marsman, Casper, Verstegen, Niels JM, Streutker, Marij, Jorritsma, Tineke, Boon, Louis, ten Brinke, Anja, Ham, S. Marieke

“…Human naïve B cells are notoriously difficult to differentiate into antibody‐secreting cells (ASCs) in vitro while maintaining sufficient cell numbers to…”
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The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages by Verbij, Fabian C., Sorvillo, Nicoletta, Kaijen, Paul H.P., Hrdinova, Johana, Peyron, Ivan, Fijnheer, Rob, ten Brinke, Anja, Meijer, Alexander B., van Alphen, Floris P.J., van den Berg, Timo K., Graversen, Jonas J.H., Moestrup, Soren K., Voorberg, Jan

“…Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to…”
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Formation and clearance of TNF-TNF inhibitor complexes during TNF inhibitor treatment by Berkhout, Lea Catharina, I'Ami, Merel Jeanne, Kruithof, Simone, Vogelzang, Erik Hans, Hooijberg, Femke, Hart, Margaretha Hendrika Louise, Bentlage, Arthur Ebel Herman, Thomas, Debby, Vermeire, Severine, Vidarsson, Gestur, Ten Brinke, Anja, Nurmohamed, Michael Twahier, Wolbink, Gerrit Jan, Rispens, Theo

“…Millions of patients with inflammatory diseases are treated with tumour necrosis factor (TNF) inhibitors (TNFi). Individual treatment response varies, in part…”
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TCR-CD3 signal strength regulates plastic coexpression of IL-4 and IFN-γ in Tfh-like cells by Verstegen, Niels J. M., Jorritsma, Tineke, ten Brinke, Anja, Barberis, Matteo, van Ham, S. Marieke

“…The development of T follicular helper (Tfh) cells is an ongoing process resulting in the formation of various Tfh subsets. Despite advancements, the precise…”
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The natalizumab wearing-off effect: End of natalizumab cycle, recurrence of MS symptoms by van Kempen, Zoé L.E, Doesburg, Djoeke, Dekker, Iris, Lissenberg-Witte, Birgit I, de Vries, Annick, Claessen, Iris A, Brinke, Anja ten, Rispens, Theo, Killestein, Joep

“…OBJECTIVENatalizumab is effective in treating relapsing-remitting multiple sclerosis (RRMS). However, many patients report an increase of multiple sclerosis…”
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DAMPS and complement activation in platelet concentrates that induce adverse reactions in patients by Wit, Yasmin E. S., Hamzeh‐Cognasse, Hind, Cognasse, Fabrice, Brinke, Anja, Zeerleder, Sacha S.

“…Background Patients with severe thrombocytopenia due to bone marrow failure and after chemotherapy are still treated with platelet transfusions. Platelet…”
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Ocrelizumab Concentration Is a Good Predictor of SARS‐CoV‐2 Vaccination Response in Patients with Multiple Sclerosis by Kempen, Zoé L. E., Hogenboom, Laura, Toorop, Alyssa A., Steenhuis, Maurice, Stalman, Eileen W., Kummer, Laura Y. L., Dam, Koos P. J., Bloem, Karien, Brinke, Anja, Ham, S. Marieke, Kuijpers, Taco W., Wolbink, Gerrit J., Loeff, Floris C., Wieske, Luuk, Eftimov, Filip, Rispens, Theo, Strijbis, Eva M. M., Killestein, Joep

“…Ocrelizumab, an anti‐CD20 monoclonal antibody, counteracts induction of humoral immune responses after severe acute respiratory syndrome‐coronavirus 2…”
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