Search Results - "ten, Cate Hugo"
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Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis
Published in Intensive care medicine (01-06-2020)“…Despite increasing improvement in extracorporeal membrane oxygenation (ECMO) technology and knowledge, thrombocytopenia and impaired platelet function are…”
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The Hemostatic System as a Modulator of Atherosclerosis
Published in The New England journal of medicine (05-05-2011)“…Experimental data suggest that the hemostatic system can accelerate plaque vulnerability to thrombosis in vivo. However, clinical support for these findings…”
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Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium
Published in Nature reviews cardiology (01-07-2022)“…Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and thromboembolic events, owing to excessive inflammation, endothelial cell activation…”
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Recommendations for the measurement of thrombin generation: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
Published in Journal of thrombosis and haemostasis (01-05-2021)“…Thrombin generation (TG) assay is an overall assay to assess the functionality of the hemostatic system and may be a useful tool in diagnosing patients with…”
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Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding
Published in Haematologica (Roma) (01-08-2020)“…Platelets are key elements in thrombosis, particularly in atherosclerosis-associated arterial thrombosis (atherothrombosis), and hemostasis. Megakaryocytes in…”
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Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis
Published in International journal of molecular sciences (04-03-2021)“…Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a…”
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Surviving Covid-19 with Heparin?
Published in The New England journal of medicine (26-08-2021)“…Patients who are admitted to the hospital with coronavirus disease 2019 (Covid-19) are at high risk for thrombosis, particularly venous thromboembolism (VTE)…”
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Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study
Published in Haematologica (Roma) (01-09-2020)“…Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims to explore the relation between…”
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EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer
Published in HemaSphere (01-08-2022)“…In cancer patients, thrombocytopenia can result from bone marrow infiltration or from anticancer medications and represents an important limitation for the use…”
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Platelet full length TFPI-α in healthy volunteers is not affected by sex or hormonal use
Published in PloS one (03-02-2017)“…Only 10% of plasma TFPIα (TFPI) exists in the full length form, the rest circulates as a C-terminally truncated form. However, blood platelets exclusively…”
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Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia
Published in Cells (Basel, Switzerland) (01-12-2021)“…Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In immune-induced thrombocytopenia (IIT), a common mechanism is…”
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Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice
Published in Scientific reports (07-03-2019)“…Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate…”
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Cost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy: Results from the thrombEVAL study
Published in Scientific reports (28-01-2021)“…To evaluate the cost-saving of a specialized, eHealth-based management service (CS) in comparison to regular medical care (RMC) for the management of patients…”
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Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis
Published in PloS one (04-05-2017)“…Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or…”
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Thromboembolic resolution assessed by CT pulmonary angiography after treatment for acute pulmonary embolism
Published in Thrombosis and haemostasis (2015)“…The systematic assessment of residual thromboembolic obstruction after treatment for acute pulmonary embolism (PE) has been understudied. This assessment is of…”
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Early atherosclerosis exhibits an enhanced procoagulant state
Published in Circulation (New York, N.Y.) (24-08-2010)“…Thrombin generation in vivo may be important in regulating atherosclerotic progression. In the present study, we examined for the first time the activity and…”
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Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation
Published in The Journal of clinical investigation (01-09-2008)“…When blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade…”
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Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events
Published in PloS one (15-07-2016)“…In acute coronary syndrome (ACS) cardiac cell damage is preceded by thrombosis. Therefore, plasma coagulation markers may have additional diagnostic relevance…”
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