Search Results - "te Riele, H"

Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application by Aarts, M, te Riele, H

“…Gene targeting by single-stranded oligodeoxyribonucleotides (ssODNs) is a promising technique for introducing site-specific sequence alterations without…”
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Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis by de Vries, S S, Baart, E B, Dekker, M, Siezen, A, de Rooij, D G, de Boer, P, te Riele, H

“…Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome…”
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Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3 by DEKKER, M, BROUWERS, C, AARTS, M, VAN DER TORRE, J, DE VRIES, S, VAN DE VRUGT, H, TE RIELE, H

“…We have previously demonstrated that site-specific insertion, deletion or substitution of one or two nucleotides in mouse embryonic stem cells (ES cells) by…”
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Oncogenic pathways impinging on the G2-restriction point by Foijer, F, Simonis, M, van Vliet, M, Wessels, L, Kerkhoven, R, Sorger, P K, te Riele, H

“…In the absence of mitogenic stimuli, cells normally arrest in G 1/0 , because they fail to pass the G 1 -restriction point. However, abrogation of the G 1…”
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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs by Schinkel, A H, Smit, J J, van Tellingen, O, Beijnen, J H, Wagenaar, E, van Deemter, L, Mol, C A, van der Valk, M A, Robanus-Maandag, E C, te Riele, H P

“…We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable and…”
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SP-0002: CRISPR/Cas9 technology: from cells to mice to stem cell therapy by Te Riele, H, Harmsen, T, Van de Vrugt, H, Riepsaame, J

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Evidence for the Lack of Mismatch-Repair Directed Antirecombination During Mouse Meiosis by Qin, J., Baker, S., Te Riele, H., Liskay, R. M., Arnheim, N.

“…Meiotic recombination was studied in DNA mismatch repair (MMR)-deficient mice using a strain carrying a Pms2 knockout mutation. Using single-sperm typing,…”
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PO-005 Prevention strategies for intestinal cancer development in lynch syndrome by Pieters, W, Wojciechowicz, K, Cantelli, E, Delzenne-Goette, E, Konink, C De, Drost, L, Riele, H Te

“…IntroductionLynch syndrome (LS) is an autosomal dominant hereditary cancer predisposition syndrome which is mostly caused by defects in DNA mismatch repair…”
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Single-Stranded Plasmid DNA in Bacillus subtilis and Staphylococcus aureus by Riele, Hein Te, Michel, Bénédicte, Ehrlich, S. Dusko

“…Plasmid pC194 was found to exist in a double-stranded and a single-stranded DNA form in Bacillus subtilis and Staphylococcus aureus. This single-stranded DNA…”
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Childhood brain tumours due to germline bi-allelic mismatch repair gene mutations by Johannesma, PC, van der Klift, HM, van Grieken, NCT, Troost, D, te Riele, H, Jacobs, MAJM, Postma, TJ, Heideman, DAM, Tops, CMJ, Wijnen, JT, Menko, FH

“…Johannesma PC, van der Klift HM, van Grieken NCT, Troost D, te Riele H, Jacobs MAJM, Postma TJ, Heideman DAM, Tops CMJ, Wijnen JT, Menko FH. Childhood brain…”
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Rolling circle replication of single‐stranded DNA plasmid pC194 by Gros, M. F., Riele, H., Ehrlich, S. D.

“…A group of small Staphylococcus aureus/Bacillus subtilis plasmids was recently found to replicate via a circular single‐stranded DNA intermediate (te Riele et…”
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Escape from premature senescence is not sufficient for oncogenic transformation by Ras by Bernards, René, Peeper, Daniel S, Dannenberg, Jan-Hermen, Douma, Sirith, Riele, Hein te

“…Resistance of primary cells to transformation by oncogenic Ras has been attributed to the induction of replicative growth arrest. This irreversible 'fail-safe…”
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Highly Efficient Gene Targeting in Embryonic Stem Cells Through Homologous Recombination with Isogenic DNA Constructs by Riele, Hein te, Maandag, Els Robanus, Berns, Anton

“…A vast amount of data suggests that homologous recombination in mammalian cells is relatively rare as compared to random integration, imposing the need for…”
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Replication origins of single-stranded-DNA plasmid pUB110 by BOE, L, GROS, M.-F, HEIN TE RIELE, DUSKO EHRLICH, S, GRUSS, A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells by te Riele, Hein, Maandag, Els Robanus, Clarke, Alan, Hooper, Martin, Berns, Anton

“…Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the…”
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Overlapping Functions of the pRb Family in the Regulation of rRNA Synthesis by Ciarmatori, Sonia, Scott, Pamela H., Sutcliffe, Josephine E., McLees, Angela, Alzuherri, Hadi M., Dannenberg, Jan-Hermen, te Riele, Hein, Grummt, Ingrid, Voit, Renate, White, Robert J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice by Maandag, E.C., Valk, M., Vlaar, M., Feltkamp, C., O'Brien, J., Roon, M., Lugt, N., Berns, A., Riele, H.

“…The requirement for a functional retinoblastoma gene, Rb‐1, in murine development around days 12‐15 of gestation precludes monitoring the effect of loss of…”
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Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice by Jacobs, H, Fukita, Y, van der Horst, G T, de Boer, J, Weeda, G, Essers, J, de Wind, N, Engelward, B P, Samson, L, Verbeek, S, de Murcia, J M, de Murcia, G, te Riele, H, Rajewsky, K

“…To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have…”
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On the Zeros of the Riemann Zeta Function in the Critical Strip. IV by van de Lune, J., H. J. J. te Riele, Winter, D. T.

“…Very extensive computations are reported which extend and, partly, check previous computations concerning the location of the complex zeros of the Riemann zeta…”
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Replication origin of a single‐stranded DNA plasmid pC194 by Gros, M.F., Riele, H., Ehrlich, S.D.

“…The replication of the single‐stranded (ss) DNA plasmid pC194 by the rolling circle mechanism was investigated using chimeric plasmids that possess two pC194…”
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