Randomized Feeding Intervention in Infants at High Risk for Celiac Disease

In this trial involving infants at high risk for celiac disease, the introduction of gluten at 4 months of age, as compared with delayed exposure to gluten until 6 months of age, did not reduce the risk of celiac disease at 3 years of age. Celiac disease, an immune-mediated systemic disorder elicite...

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Published in:	The New England journal of medicine Vol. 371; no. 14; pp. 1304 - 1315
Main Authors:	Vriezinga, Sabine L, Auricchio, Renata, Bravi, Enzo, Castillejo, Gemma, Chmielewska, Anna, Crespo Escobar, Paula, Kolaček, Sanja, Koletzko, Sibylle, Korponay-Szabo, Ilma R, Mummert, Eckart, Polanco, Isabel, Putter, Hein, Ribes-Koninckx, Carmen, Shamir, Raanan, Szajewska, Hania, Werkstetter, Katharina, Greco, Luigi, Gyimesi, Judit, Hartman, Corina, Hogen Esch, Caroline, Hopman, Erica, Ivarsson, Anneli, Koltai, Tunde, Koning, Frits, Martinez-Ojinaga, Eva, te Marvelde, Chantal, Pavic, Ana, Romanos, Jihane, Stoopman, Els, Villanacci, Vincenzo, Wijmenga, Cisca, Troncone, Ricardo, Mearin, M. Luisa
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 02-10-2014
Subjects:	Age Antibodies Autoantibodies - blood Babies Biological and medical sciences Biopsy Breast Feeding Celiac disease Celiac Disease - diagnosis Celiac Disease - genetics Celiac Disease - prevention & control Child Child, Preschool Children Clinical trials Diet Dietary Proteins - administration & dosage Double-Blind Method Feeding Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen General aspects Genotype Gliadin Gliadin - immunology Gluten Glutens - administration & dosage GTP-Binding Proteins - immunology Histocompatibility antigen HLA HLA-DQ Antigens - genetics Humans Infant Infants Intervention Intestine, Small - pathology Male Medical sciences Nutrition Other diseases. Semiology Proportional Hazards Models Prospective Studies Risk Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transglutaminase 2 Transglutaminases - immunology Netherlands Israel Human Medicine Immunopathology Intestinal malabsorption Digestive diseases Intestinal disease Infant Coeliac disease Feeding
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Summary:	In this trial involving infants at high risk for celiac disease, the introduction of gluten at 4 months of age, as compared with delayed exposure to gluten until 6 months of age, did not reduce the risk of celiac disease at 3 years of age. Celiac disease, an immune-mediated systemic disorder elicited by gluten in genetically susceptible persons, is characterized by anti–transglutaminase type 2 antibodies (TG2A) and enteropathy. 1 The prevalence of celiac disease is 1 to 3% in the general population and approximately 10% among first-degree family members of patients with celiac disease. 2 – 10 Celiac disease is treated with a gluten-free diet. More than 95% of patients have the HLA-DQ2 heterodimer, either in the cis or trans configuration. Most of the remaining patients have the HLA-DQ8 heterodimer or half of the HLA-DQ2 heterodimer (DQB1*02). 1 , 8 , 11 – 14 However, more than 25% of the general population . . .
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1404172