Search Results - "ster, Nicole"

Complications, reoperations and revisions after proximal interphalangeal joint arthroplasty: a systematic review and meta-analysis by Forster, Nicole, Schindele, Stephan, Audigé, Laurent, Marks, Miriam

“…This systematic review and meta-analysis investigates the prevalence of complications, reoperations (surgeries without implant modifications) and revisions…”
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Physical Association of HDAC1 and HDAC2 with p63 Mediates Transcriptional Repression and Tumor Maintenance in Squamous Cell Carcinoma by RAMSEY, Matthew R, LEI HE, FORSTER, Nicole, ORY, Benjamin, ELLISEN, Leif W

“…Squamous cell carcinoma (SCC) is a treatment-refractory subtype of human cancer arising from stratified epithelium of the skin, lung, esophagus, oropharynx,…”
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Basal Cell Signaling by p63 Controls Luminal Progenitor Function and Lactation via NRG1 by Forster, Nicole, Saladi, Srinivas Vinod, van Bragt, Maaike, Sfondouris, Mary E., Jones, Frank E., Li, Zhe, Ellisen, Leif W.

“…The mammary epithelium is organized as a bilayer of luminal and basal/myoepithelial cells. During pregnancy, the luminal compartment expands for milk…”
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Opportunistic genomic screening has clinical utility: An interventional cohort study by Mighton, Chloe, Kodida, Rita, Shickh, Salma, Clausen, Marc, Reble, Emma, Sam, Jordan, Grewal, Sonya, Hirjikaka, Daena, Panchal, Seema, Piccinin, Carolyn, Aronson, Melyssa, Ward, Thomas, Armel, Susan Randall, Hofstedter, Renee, Graham, Tracy, Mancuso, Talia, Forster, Nicole, Capo-Chichi, José-Mario, Greenfeld, Elena, Noor, Abdul, Cohn, Iris, Morel, Chantal F., Elser, Christine, Eisen, Andrea, Carroll, June C., Glogowksi, Emily, Schrader, Kasmintan A., Chan, Kelvin K.W., Thorpe, Kevin E., Lerner-Ellis, Jordan, Kim, Raymond H., Bombard, Yvonne

“…Practice is shifting toward genome-first approaches, such as opportunistic screening for secondary findings (SFs). Analysis of SFs could be extended beyond…”
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A model for the return and referral of all clinically significant secondary findings of genomic sequencing by Kodida, Rita, Reble, Emma, Clausen, Marc, Shickh, Salma, Mighton, Chloe, Sam, Jordan, Forster, Nicole, Panchal, Seema, Aronson, Melyssa, Semotiuk, Kara, Graham, Tracy, Silberman, Yael, Randall Armel, Susan, McCuaig, Jeanna M, Cohn, Iris, Morel, Chantal F, Elser, Christine, Eisen, Andrea, Carroll, June C, Glogowski, Emily, Schrader, Kasmintan A, Di Gioacchino, Vanessa, Lerner-Ellis, Jordan, Kim, Raymond H, Bombard, Yvonne

“…Secondary findings (SFs) identified through genomic sequencing (GS) can offer a wide range of health benefits to patients. Resource and capacity constraints…”
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A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma by Ory, Benjamin, Ramsey, Matthew R, Wilson, Catherine, Vadysirisack, Douangsone D, Forster, Nicole, Rocco, James W, Rothenberg, S Michael, Ellisen, Leif W

“…The p53 tumor suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many human cancers. Therefore, a central…”
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The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers by Yang, Chuanwei, Hayashida, Tetsu, Forster, Nicole, Li, Cuiqi, Shen, Dejun, Maheswaran, Shyamala, Chen, Li, Anderson, Karen S, Ellisen, Leif W, Sgroi, Dennis, Schmidt, Emmett V

“…The progression from preinvasive lesion to invasive carcinoma is a critical step contributing to breast cancer lethality. We identified downregulation of milk…”
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Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma by He, Lei, Torres-Lockhart, Kristine, Forster, Nicole, Ramakrishnan, Saranya, Greninger, Patricia, Garnett, Mathew J, McDermott, Ultan, Rothenberg, Stephen M, Benes, Cyril H, Ellisen, Leif W

“…Effective targeted therapeutics for squamous cell carcinoma (SCC) are lacking. Here, we uncover Mcl-1 as a dominant and tissue-specific survival factor in SCC,…”
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OTX2 mutations cause autosomal dominant pattern dystrophy of the retinal pigment epithelium by Vincent, Ajoy, Forster, Nicole, Maynes, Jason T, Paton, Tara A, Billingsley, Gail, Roslin, Nicole M, Ali, Arfan, Sutherland, Joanne, Wright, Tom, Westall, Carol A, Paterson, Andrew D, Marshall, Christian R, Héon, Elise

“…To identify the genetic cause of autosomal-dominant pattern dystrophy (PD) of the retinal pigment epithelium (RPE) in two families. Two families with…”
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Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation by Weber, Axel, Marquardt, Judith, Elzi, David, Forster, Nicole, Starke, Sven, Glaum, Andre, Yamada, Daisuke, Defossez, Pierre-Antoine, Delrow, Jeffrey, Eisenman, Robert N, Christiansen, Holger, Eilers, Martin

“…In response to stimuli that activate p53, cells can undergo either apoptosis or cell cycle arrest, depending on the precise pattern of p53 target genes that is…”
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Notch signaling mediates p63-induced quiescence: A new facet of p63/Notch crosstalk by Forster, Nicole, Ellisen, Leif W.

“…Comment on: Kent S, et al. Cell Cycle 2011; 10:3111-8…”
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p300 Protein Acetyltransferase Activity Suppresses Systemic Lupus Erythematosus-Like Autoimmune Disease in Mice by Forster, Nicole, Gallinat, Sven, Jablonska, Jadwiga, Weiss, Siegfried, Elsasser, Hans-Peter, Lutz, Werner

“…Conditional knock-in mice expressing a histone acetyltransferase-deficient version of the transcriptional coregulator p300 exclusively in B lymphocytes die…”
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Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer by Adler, Annette, Forster, Nicole, Homann, Matthias, Göringer, H Ulrich

“…African trypanosomes are the causative agent of sleeping sickness. The therapeutics used to control and treat the disease are very ineffective and thus, the…”
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The Integrin alpha v beta 3-5 Ligand MFG-E8 Is a p63/p73 Target Gene in Triple-Negative Breast Cancers but Exhibits Suppressive Functions in ER+ and erbB2+ Breast Cancers by Yang, Chuanwei, Hayashida, Tetsu, ster, Nicole, Li, Cuiqi, Shen, Dejun, Maheswaran, Shyamala, Chen, Li, Anderson, Karen S, Ellisen, Leif W, Sgroi, Dennis, Schmidt, Emmett V

“…The progression from preinvasive lesion to invasive carcinoma is a critical step contributing to breast cancer lethality. We identified downregulation of milk…”
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Managing elevated intracranial pressure by Forster, Nicole, Engelhard, Kristin

“…Elevated intracranial pressure is one of the major deteriorating factors in patients with intracerebral lesions. Therefore, every year many experimental and…”
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The fibroblast growth factor receptor inhibitor, derazantinib, has strong efficacy in human gastric tumor models and synergizes with paclitaxel in vivo by McSheehy, Paul M.J., Forster-Gross, Nicole, El Shemerly, Mahmoud, Bachmann, Felix, Roceri, Mila, Hermann, Norbert, Spickermann, Jochen, Kellenberger, Laurenz, Lane, Heidi A.

“…Derazantinib (DZB) is an inhibitor of fibroblast growth factor receptors 1–3 (FGFR1–3), with additional activity against colony-stimulating-factor-1 receptor…”
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Derazantinib: an investigational drug for the treatment of cholangiocarcinoma by Braun, Stephan, McSheehy, Paul, Litherland, Karine, McKernan, Phil, Forster-Gross, Nicole, Bachmann, Felix, El-Shemerly, Mahmoud, Dimova-Dobreva, Miryana, Polyakova, Inessa, Häckl, Manuel, Zhou, Ping, Lane, Heidi, Kellenberger, Laurenz, Engelhardt, Marc

“…This review evaluates the clinical role of fibroblast growth factor receptor 2 (FGFR2) inhibition with derazantinib in patients with intrahepatic…”
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Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination by Zanini, Elisa, Forster-Gross, Nicole, Bachmann, Felix, Brüngger, Adrian, McSheehy, Paul, Litherland, Karine, Burger, Karin, Groner, Anna C, Roceri, Mila, Bury, Luc, Stieger, Martin, Willemsen-Seegers, Nicole, de Man, Jos, Vu-Pham, Diep, van Riel, Helma W E, Zaman, Guido J R, Buijsman, Rogier C, Kellenberger, Laurenz, Lane, Heidi A

“…Threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) are common essential kinases that collaborate in activating the spindle assembly checkpoint (SAC)…”
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The influence of injection rate on the hypnotic effect of propofol during anesthesia: a randomized trial by Blum, Jasmin, Kochs, Eberhard, Forster, Nicole, Schneider, Gerhard

“…Previous studies suggested that slow injection of propofol may increase the hypnotic effect during induction of anesthesia. The aim of the present study was…”
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The microtubule-targeted agent lisavanbulin (BAL101553) shows anti-tumor activity in lymphoma models by Spriano, Filippo, Aresu, Luca, Cascione, Luciano, Risi, Giorgia, Arribas, Alberto J, Napoli, Sara, Forster-Gross, Nicole, Bachmann, Felix, Engelhardt, Marc, Lane, Heidi, Bertoni, Francesco

“…Microtubules are major components of the cellular cytoskeleton, ubiquitously founded in all eukaryotic cells. They are involved in mitosis, cell motility,…”
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