Search Results - "sacchettini, C."

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis by Ioerger, Thomas R, O'Malley, Theresa, Liao, Reiling, Guinn, Kristine M, Hickey, Mark J, Mohaideen, Nilofar, Murphy, Kenan C, Boshoff, Helena I M, Mizrahi, Valerie, Rubin, Eric J, Sassetti, Christopher M, Barry, 3rd, Clifton E, Sherman, David R, Parish, Tanya, Sacchettini, James C

“…Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of…”
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TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities by Carey, Allison F, Rock, Jeremy M, Krieger, Inna V, Chase, Michael R, Fernandez-Suarez, Marta, Gagneux, Sebastien, Sacchettini, James C, Ioerger, Thomas R, Fortune, Sarah M

“…Once considered a phenotypically monomorphic bacterium, there is a growing body of work demonstrating heterogeneity among Mycobacterium tuberculosis (Mtb)…”
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Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing by Zhang, Yanjia J., Reddy, Manchi C., Ioerger, Thomas R., Rothchild, Alissa C., Dartois, Veronique, Schuster, Brian M., Trauner, Andrej, Wallis, Deeann, Galaviz, Stacy, Huttenhower, Curtis, Sacchettini, James C., Behar, Samuel M., Rubin, Eric J.

“…Bacteria that cause disease rely on their ability to counteract and overcome host defenses. Here, we present a genome-scale study of Mycobacterium tuberculosis…”
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Global assessment of genomic regions required for growth in Mycobacterium tuberculosis by Zhang, Yanjia J, Ioerger, Thomas R, Huttenhower, Curtis, Long, Jarukit E, Sassetti, Christopher M, Sacchettini, James C, Rubin, Eric J

“…Identifying genomic elements required for viability is central to our understanding of the basic physiology of bacterial pathogens. Recently, the combination…”
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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice by Guthrie, Liam M, Soma, Shivatheja, Yuan, Sai, Silva, Andres, Zulkifli, Mohammad, Snavely, Thomas C, Greene, Hannah Faith, Nunez, Elyssa, Lynch, Brogan, De Ville, Courtney, Shanbhag, Vinit, Lopez, Franklin R, Acharya, Arjun, Petris, Michael J, Kim, Byung-Eun, Gohil, Vishal M, Sacchettini, James C

“…Loss-of-function mutations in the copper (Cu) transporter ATP7A cause Menkes disease. Menkes is an infantile, fatal, hereditary copper-deficiency disorder that…”
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A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide by Yadon, Adam N., Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Rubin, Eric J., Pym, Alexander S.

“…Tuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated…”
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The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD by Sun, Qingan, Li, Xiaojun, Perez, Lisa M., Shi, Wanliang, Zhang, Ying, Sacchettini, James C.

“…Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria…”
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Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis by Jansen, Robert S., Mandyoli, Lungelo, Hughes, Ryan, Wakabayashi, Shoko, Pinkham, Jessica T., Selbach, Bruna, Guinn, Kristine M., Rubin, Eric J., Sacchettini, James C., Rhee, Kyu Y.

“…Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function…”
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Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists by Katti, Sachin S., Krieger, Inna V., Ann, Jihyae, Lee, Jeewoo, Sacchettini, James C., Igumenova, Tatyana I.

“…Diacylglycerol (DAG) is a versatile lipid whose 1,2- sn -stereoisomer serves both as second messenger in signal transduction pathways that control vital…”
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Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection by Ford, Christopher B, Lin, Philana Ling, Chase, Michael R, Shah, Rupal R, Iartchouk, Oleg, Galagan, James, Mohaideen, Nilofar, Ioerger, Thomas R, Sacchettini, James C, Lipsitch, Marc, Flynn, JoAnne L, Fortune, Sarah M

“…Sarah Fortune and colleagues report the whole-genome sequencing of Mycobacterium tuberculosis strains isolated from cynomolgus macaques with either active,…”
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Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe by Xie, Hexin, Mire, Joseph, Kong, Ying, Chang, MiHee, Hassounah, Hany A., Thornton, Chris N., Sacchettini, James C., Cirillo, Jeffrey D., Rao, Jianghong

“…Early diagnosis of tuberculosis can dramatically reduce both its transmission and the associated death rate. The extremely slow growth rate of the causative…”
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Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis by Cui, Zhicheng, Li, Xiaojun, Shin, Joonyoung, Gamper, Howard, Hou, Ya-Ming, Sacchettini, James C., Zhang, Junjie

“…EttA, energy-dependent translational throttle A, is a ribosomal factor that gates ribosome entry into the translation elongation cycle. A detailed…”
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A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears by Gordon, Paul D, De Ville, Courtney, Sacchettini, James C, Coté, Gerard L

“…Malaria is often most endemic in remote regions where diagnostic microscopy services are unavailable. In such regions, the use of rapid diagnostic tests fails…”
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Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome by Li, Xiaojun, Sun, Qingan, Jiang, Cai, Yang, Kailu, Hung, Li-Wei, Zhang, Junjie, Sacchettini, James C.

“…The ribosomal silencing factor RsfS slows cell growth by inhibiting protein synthesis during periods of diminished nutrient availability. The crystal structure…”
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis by Kreutzfeldt, Kaj M., Jansen, Robert S., Hartman, Travis E., Gouzy, Alexandre, Wang, Ruojun, Krieger, Inna V., Zimmerman, Matthew D., Gengenbacher, Martin, Sarathy, Jansy P., Xie, Min, Dartois, Véronique, Sacchettini, James C., Rhee, Kyu Y., Schnappinger, Dirk, Ehrt, Sabine

“…The ability of Mycobacterium tuberculosis ( Mtb ) to resist and tolerate antibiotics complicates the development of improved tuberculosis (TB) chemotherapies…”
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Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl by Bhatt, Veer S., Zeng, Danyun, Krieger, Inna, Sacchettini, James C., Cho, Jae-Hyun

“…The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of…”
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Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis by Mackenzie, Jared S., Lamprecht, Dirk A., Asmal, Rukaya, Adamson, John H., Borah, Khushboo, Beste, Dany J. V., Lee, Bei Shi, Pethe, Kevin, Rousseau, Simon, Krieger, Inna, Sacchettini, James C., Glasgow, Joel N., Steyn, Adrie J. C.

“…The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic…”
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MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212 by LA ROSA, Valentina, POCE, Giovanna, JAVID, Babak, SORRENTINO, Flavia, LOERGER, Thomas R, SACCHETTINI, James C, MANETTI, Fabrizio, BOTTA, Maurizio, DE LOGU, Alessandro, RUBIN, Eric J, DE ROSSI, Edda, ORTIZ CANSECO, Julio, BURONI, Silvia, PASCA, Maria Rosalia, BIAVA, Mariangela, RAJU, Ravikiran M, PORRETTA, Giulio Cesare, ALFONSO, Salvatore, BATTILOCCHIO, Claudio

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility by Kieser, Karen J, Baranowski, Catherine, Chao, Michael C, Long, Jarukit E, Sassetti, Christopher M, Waldor, Matthew K, Sacchettini, James C, Ioerger, Thomas R, Rubin, Eric J

“…Peptidoglycan (PG), a complex polymer composed of saccharide chains cross-linked by short peptides, is a critical component of the bacterial cell wall. PG…”
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Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research by Daniel-Wayman, Shelby, Abate, Getahun, Barber, Daniel L, Bermudez, Luiz E, Coler, Rhea N, Cynamon, Michael H, Daley, Charles L, Davidson, Rebecca M, Dick, Thomas, Floto, R Andres, Henkle, Emily, Holland, Steven M, Jackson, Mary, Lee, Richard E, Nuermberger, Eric L, Olivier, Kenneth N, Ordway, Diane J, Prevots, D Rebecca, Sacchettini, James C, Salfinger, Max, Sassetti, Christopher M, Sizemore, Christine F, Winthrop, Kevin L, Zelazny, Adrian M

“…Development of Preventive and Treatment Strategies Will Require a More In-Depth Understanding of Host-Pathogen Interactions Host and pathogen factors are known…”
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