Search Results - "man, Mark"
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Risk Management Strategies to Cope Catastrophic Risks in Agriculture: The Case of Contract Farming, Diversification and Precautionary Savings
Published in Agriculture (Basel) (01-08-2020)“…Risk management is an essential way for farmers to reduce uncertainty. In this research, a stratified random sampling method was used to survey 350 maize…”
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Simultaneous adoption of diversification and agricultural credit to manage catastrophic risk for maize production in Bangladesh
Published in Environmental science and pollution research international (01-11-2021)“…Risk management strategies are made up of response variability that may lessen the likeliness of an unfavorable event occurring and/or decrease the damaging…”
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Effect of music breathing, a program based on mindful breathing and music listening therapy for promoting sense of coherence in young people: study protocol for a randomized controlled trial
Published in Current controlled trials in cardiovascular medicine (12-10-2023)“…Background The negative impacts of the COVID-19 pandemic on public health have affected people socially, psychologically, and physically. Young people…”
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Weather Information Acquisition and Health Significance during Extreme Cold Weather in a Subtropical City: A Cross-sectional Survey in Hong Kong
Published in International journal of disaster risk science (01-06-2017)“…Health and disaster risk reduction are important and necessary components in building a smart city, especially when climate change may increase the frequency…”
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Health Emergency and Disaster Risk Management (Health-EDRM) in Remote Ethnic Minority Areas of Rural China:The Case of a Flood-Prone Village in Sichuan
Published in International journal of disaster risk science (01-06-2017)“…Remote,rural ethnic-minority communities face greater disaster-related public health risks due to their lack of resources and limited access to health care.The…”
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Family and Parental Decision Making When Choosing a Paediatric General Practice Service: What Factors Mattered Most?
Published in Child care in practice : Northern Ireland journal of multi-disciplinary child care practice (01-10-2024)“…In today's highly demanding health care industry, paediatricians realise the need to focus on what matters to parents as a means to improve their service…”
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Characterization of Risk Factors for Calciphylaxis in Hemodialysis Patients in the Fraser Health Renal Program – A Matched Case-Control Retrospective Review
Published in Journal of pharmacy practice (01-12-2023)“…Introduction: Calciphylaxis is a lethal and rare disease characterized by ischemic and necrotic skin lesions caused by vascular calcification of adipose…”
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Assessing farmers’ intention towards conservation agriculture by using the Extended Theory of Planned Behavior
Published in Journal of environmental management (15-02-2021)“…Conservation agriculture is considered as an agro-ecological approach to the sustainable and resource-saving crop production system. Previous studies on the…”
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Evaluation of Rasburicase Use in the Fraser Health Authority: A Retrospective Review
Published in Canadian journal of hospital pharmacy (01-07-2019)“…Rasburicase, a recombinant urate oxidase, is restricted in the Fraser Health Authority (FHA) to the "treatment of acute or at high risk of tumour lysis…”
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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Published in Science translational medicine (02-11-2016)“…β-Amyloid (Aβ) peptides are thought to be critically involved in the etiology of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor…”
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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
Published in Journal of medicinal chemistry (08-12-2016)“…Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein…”
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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
Published in Nature medicine (01-10-2004)“…A wide variety of neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates. More recently, the…”
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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Published in Annals of neurology (01-05-2007)“…Objective Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately 10% of cases are familial ALS…”
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TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97
Published in The Journal of neuroscience (02-06-2010)“…Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by…”
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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
Published in Acta neuropathologica (01-02-2009)“…Accumulation of hyperphosphorylated, ubiquitinated and N-terminally truncated TAR DNA-binding protein (TDP-43) is the pathological hallmark lesion in most…”
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Pharmacokinetics and Pharmacodynamics of the BACE1 Inhibitor Verubecestat (MK‐8931) in Healthy Japanese Adults: A Randomized, Placebo‐Controlled Study
Published in Clinical pharmacology and therapeutics (01-05-2019)“…β‐site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of β‐amyloid (Aβ) peptides and is considered a potential treatment…”
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Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies
Published in Journal of neuropathology and experimental neurology (01-06-2008)“…Pathologic TAR-DNA-binding protein 43 (TDP-43) is a disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and…”
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Published in Scientific reports (03-06-2016)“…Orexin neuropeptides regulate sleep/wake through orexin receptors (OX 1 R, OX 2 R); OX 2 R is the predominant mediator of arousal promotion. The potential for…”
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Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development
Published in Alzheimer's & dementia : translational research & clinical interventions (01-01-2017)“…Abstract Dementia is often characterized as being caused by one of several major diseases, such as Alzheimer's disease (AD), cerebrovascular disease, Lewy body…”
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TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions
Published in The American journal of pathology (01-07-2007)“…TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive,…”
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