Search Results - "man, Henry J"
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How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo
Published in Free radical biology & medicine (01-01-2014)“…We present arguments for an evolution in our understanding of how antioxidants in fruits and vegetables exert their health-protective effects. There is much…”
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Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain
Published in Environmental health perspectives (01-10-2016)“…Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution…”
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Progress in HNE Biology
Published in Archives of biochemistry and biophysics (01-02-2023)Get full text
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Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
Published in Nature metabolism (01-06-2022)“…Multiple roles of reactive oxygen species (ROS) and their consequences for health and disease are emerging throughout biological sciences. This development has…”
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Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress
Published in The Journal of biological chemistry (23-03-2012)“…The ability to adapt to acute oxidative stress (e.g. H2O2, peroxynitrite, menadione, and paraquat) through transient alterations in gene expression is an…”
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Redox-based regulation of signal transduction: Principles, pitfalls, and promises
Published in Free radical biology & medicine (01-07-2008)“…Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from prokaryotes to mammals have evolved with an elaborate and redundant…”
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Air pollution: Consequences for cellular redox signaling, antioxidant defenses and disease
Published in Free radical biology & medicine (01-05-2020)Get full text
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Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
Published in Molecular aspects of medicine (01-02-2009)“…Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and rate-limiting step in GSH synthesis is catalyzed by glutamate…”
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Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine
Published in Free radical biology & medicine (01-11-2015)Get full text
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The ‘mitoflash’ probe cpYFP does not respond to superoxide
Published in Nature (London) (23-10-2014)“…Arising from E.-Z. Shen et al. Nature508, 128–132 (2014); doi:10.1038/nature1301210.1038/nature13012 Ageing and lifespan of organisms are determined by…”
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Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage
Published in Biochimica et biophysica acta. Molecular basis of disease (01-10-2015)“…A strong correlation between oxidative stress (OS) and Rett syndrome (RTT), a rare neurodevelopmental disorder affecting females in the 95% of the cases, has…”
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Glutathione peroxidase 8 is transcriptionally regulated by HIFα and modulates growth factor signaling in HeLa cells
Published in Free radical biology & medicine (01-04-2015)“…GPx8 is a mammalian Cys-glutathione peroxidase of the endoplasmic reticulum membrane, involved in protein folding. Its regulation is mostly unknown. We…”
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Tricuspid regurgitant jet velocity and myocardial tissue Doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups ‐ revisiting this controversial concept after 16 years of additional evidence
Published in American journal of hematology (01-01-2021)“…Sickle cell disease (SCD) is a monogenic hemoglobinopathy associated with significant morbidity and mortality. Cardiopulmonary, vascular and sudden death are…”
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Tricuspid regurgitant jet velocity and myocardial tissue Doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups ‐ revisiting this controversial concept after 16years of additional evidence
Published in American journal of hematology (01-01-2021)“…Sickle cell disease (SCD) is a monogenic hemoglobinopathy associated with significant morbidity and mortality. Cardiopulmonary, vascular and sudden death are…”
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Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts
Published in Free radical biology & medicine (01-01-2019)“…Diabetic hearts are susceptible to damage from inappropriate activation of the renin angiotensin system (RAS) and hyperglycemic events both of which contribute…”
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The Oxygen Paradox, the French Paradox, and age-related diseases
Published in GeroScience (01-12-2017)“…A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently…”
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Hexokinase from the white shrimp Litopenaeus vannamei: cDNA sequence, structural protein model and regulation via HIF-1 in response to hypoxia
Published in Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (01-03-2011)“…Hexokinase (HK) catalyzes the phosphorylation of glucose, the first rate-limiting step in glycolysis. HKs are a conserved family of tissue-specific isozymes,…”
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Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A₂ Activity at Cytoplasmic pH
Published in Antioxidants (24-12-2018)“…The expression of the phospholipase A₂ activity (aiPLA₂) of peroxiredoxin 6 (Prdx6) in the cell cytoplasm is physiologically relevant for the repair of…”
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The 'mitoflash' probe cpYFP does not respond to superoxide/Cheng et al. reply
Published in Nature (London) (23-10-2014)“…Exposure of cpYFP to a superoxide-generating system (xanthine (X) and xanthine oxidase (XO)) slightly changed the excitation and emission spectra.However, the…”
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Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy
Published in The Journal of biological chemistry (05-12-2008)“…Macroautophagy, a tightly orchestrated intracellular process for bulk degradation of cytoplasmic proteins or organelles, is believed to be essential for cell…”
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