Search Results - "mBio"

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease by Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

“…Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated…”
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Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers by Baxter, Nielson T, Schmidt, Alexander W, Venkataraman, Arvind, Kim, Kwi S, Waldron, Clive, Schmidt, Thomas M

“…Production of short-chain fatty acids (SCFAs), especially butyrate, in the gut microbiome is required for optimal health but is frequently limited by the lack…”
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Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis by Gralinski, Lisa E, Sheahan, Timothy P, Morrison, Thomas E, Menachery, Vineet D, Jensen, Kara, Leist, Sarah R, Whitmore, Alan, Heise, Mark T, Baric, Ralph S

“…Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are observed in severe cases of severe acute respiratory syndrome coronavirus…”
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Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants by Crits-Christoph, Alexander, Kantor, Rose S, Olm, Matthew R, Whitney, Oscar N, Al-Shayeb, Basem, Lou, Yue Clare, Flamholz, Avi, Kennedy, Lauren C, Greenwald, Hannah, Hinkle, Adrian, Hetzel, Jonathan, Spitzer, Sara, Koble, Jeffery, Tan, Asako, Hyde, Fred, Schroth, Gary, Kuersten, Scott, Banfield, Jillian F, Nelson, Kara L

“…Viral genome sequencing has guided our understanding of the spread and extent of genetic diversity of SARS-CoV-2 during the COVID-19 pandemic. SARS-CoV-2 viral…”
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From People to Panthera : Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo by McAloose, Denise, Laverack, Melissa, Wang, Leyi, Killian, Mary Lea, Caserta, Leonardo C, Yuan, Fangfeng, Mitchell, Patrick K, Queen, Krista, Mauldin, Matthew R, Cronk, Brittany D, Bartlett, Susan L, Sykes, John M, Zec, Stephanie, Stokol, Tracy, Ingerman, Karen, Delaney, Martha A, Fredrickson, Richard, Ivančić, Marina, Jenkins-Moore, Melinda, Mozingo, Katie, Franzen, Kerrie, Bergeson, Nichole Hines, Goodman, Laura, Wang, Haibin, Fang, Ying, Olmstead, Colleen, McCann, Colleen, Thomas, Patrick, Goodrich, Erin, Elvinger, François, Smith, David C, Tong, Suxiang, Slavinski, Sally, Calle, Paul P, Terio, Karen, Torchetti, Mia Kim, Diel, Diego G

“…Despite numerous barriers to transmission, zoonoses are the major cause of emerging infectious diseases in humans. Among these, severe acute respiratory…”
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Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture by Fisher, Matthew C, Gurr, Sarah J, Cuomo, Christina A, Blehert, David S, Jin, Hailing, Stukenbrock, Eva H, Stajich, Jason E, Kahmann, Regine, Boone, Charles, Denning, David W, Gow, Neil A R, Klein, Bruce S, Kronstad, James W, Sheppard, Donald C, Taylor, John W, Wright, Gerard D, Heitman, Joseph, Casadevall, Arturo, Cowen, Leah E

“…The fungal kingdom includes at least 6 million eukaryotic species and is remarkable with respect to its profound impact on global health, biodiversity,…”
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Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate by Carroll, Laura M, Gaballa, Ahmed, Guldimann, Claudia, Sullivan, Genevieve, Henderson, Lory O, Wiedmann, Martin

“…Mobilized colistin resistance ( ) genes are plasmid-borne genes that confer resistance to colistin, an antibiotic used to treat severe bacterial infections. To…”
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Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of Diagnostic Testing for SARS-CoV-2/COVID-19 by Patel, Robin, Babady, Esther, Theel, Elitza S, Storch, Gregory A, Pinsky, Benjamin A, St George, Kirsten, Smith, Tara C, Bertuzzi, Stefano

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Bacterial Quorum Sensing and Microbial Community Interactions by Abisado, Rhea G, Benomar, Saida, Klaus, Jennifer R, Dandekar, Ajai A, Chandler, Josephine R

“…Many bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing…”
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Origins and Evolution of the Global RNA Virome by Wolf, Yuri I, Kazlauskas, Darius, Iranzo, Jaime, Lucía-Sanz, Adriana, Kuhn, Jens H, Krupovic, Mart, Dolja, Valerian V, Koonin, Eugene V

“…Viruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in animals and plants. The recent advances of metaviromics prompted us to…”
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Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses by Chow, Nancy A, Muñoz, José F, Gade, Lalitha, Berkow, Elizabeth L, Li, Xiao, Welsh, Rory M, Forsberg, Kaitlin, Lockhart, Shawn R, Adam, Rodney, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Althawadi, Sahar, Araúz, Ana Belén, Ben-Ami, Ronen, Bharat, Amrita, Calvo, Belinda, Desnos-Ollivier, Marie, Escandón, Patricia, Gardam, Dianne, Gunturu, Revathi, Heath, Christopher H, Kurzai, Oliver, Martin, Ronny, Litvintseva, Anastasia P, Cuomo, Christina A

“…has emerged globally as a multidrug-resistant yeast that can spread via nosocomial transmission. An initial phylogenetic study of isolates from Japan, India,…”
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A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus by Ganaie, Feroze, Saad, Jamil S, McGee, Lesley, van Tonder, Andries J, Bentley, Stephen D, Lo, Stephanie W, Gladstone, Rebecca A, Turner, Paul, Keenan, Jeremy D, Breiman, Robert F, Nahm, Moon H

“…(pneumococcus) is a major human pathogen producing structurally diverse capsular polysaccharides. Widespread use of highly successful pneumococcal conjugate…”
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Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins by Klemm, Elizabeth J, Shakoor, Sadia, Page, Andrew J, Qamar, Farah Naz, Judge, Kim, Saeed, Dania K, Wong, Vanessa K, Dallman, Timothy J, Nair, Satheesh, Baker, Stephen, Shaheen, Ghazala, Qureshi, Shahida, Yousafzai, Mohammad Tahir, Saleem, Muhammad Khalid, Hasan, Zahra, Dougan, Gordon, Hasan, Rumina

“…Antibiotic resistance is a major problem in serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia…”
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The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing by Chakravorty, Soumitesh, Simmons, Ann Marie, Rowneki, Mazhgan, Parmar, Heta, Cao, Yuan, Ryan, Jamie, Banada, Padmapriya P, Deshpande, Srinidhi, Shenai, Shubhada, Gall, Alexander, Glass, Jennifer, Krieswirth, Barry, Schumacher, Samuel G, Nabeta, Pamela, Tukvadze, Nestani, Rodrigues, Camilla, Skrahina, Alena, Tagliani, Elisa, Cirillo, Daniela M, Davidow, Amy, Denkinger, Claudia M, Persing, David, Kwiatkowski, Robert, Jones, Martin, Alland, David

“…The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance (RIF-R) suitable for point-of-care testing. However, it has…”
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Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway by Haran, John P, Bhattarai, Shakti K, Foley, Sage E, Dutta, Protiva, Ward, Doyle V, Bucci, Vanni, McCormick, Beth A

“…The microbiota-gut-brain axis is a bidirectional communication system that is poorly understood. Alzheimer's disease (AD), the most common cause of dementia,…”
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Comparative Analyses of Vertebrate Gut Microbiomes Reveal Convergence between Birds and Bats by Song, Se Jin, Sanders, Jon G, Delsuc, Frédéric, Metcalf, Jessica, Amato, Katherine, Taylor, Michael W, Mazel, Florent, Lutz, Holly L, Winker, Kevin, Graves, Gary R, Humphrey, Gregory, Gilbert, Jack A, Hackett, Shannon J, White, Kevin P, Skeen, Heather R, Kurtis, Sarah M, Withrow, Jack, Braile, Thomas, Miller, Matthew, McCracken, Kevin G, Maley, James M, Ezenwa, Vanessa O, Williams, Allison, Blanton, Jessica M, McKenzie, Valerie J, Knight, Rob

“…Diet and host phylogeny drive the taxonomic and functional contents of the gut microbiome in mammals, yet it is unknown whether these patterns hold across all…”
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Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19 by Pace, Ryan M, Williams, Janet E, Järvinen, Kirsi M, Belfort, Mandy B, Pace, Christina D W, Lackey, Kimberly A, Gogel, Alexandra C, Nguyen-Contant, Phuong, Kanagaiah, Preshetha, Fitzgerald, Theresa, Ferri, Rita, Young, Bridget, Rosen-Carole, Casey, Diaz, Nichole, Meehan, Courtney L, Caffé, Beatrice, Sangster, Mark Y, Topham, David, McGuire, Mark A, Seppo, Antti, McGuire, Michelle K

“…Whether mother-to-infant SARS-CoV-2 transmission can occur during breastfeeding and, if so, whether the benefits of breastfeeding outweigh this risk during…”
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Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli by Yin, Wenjuan, Li, Hui, Shen, Yingbo, Liu, Zhihai, Wang, Shaolin, Shen, Zhangqi, Zhang, Rong, Walsh, Timothy R, Shen, Jianzhong, Wang, Yang

“…The mobile colistin resistance gene has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the…”
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The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines by McLean, Gary, Kamil, Jeremy, Lee, Benhur, Moore, Penny, Schulz, Thomas F, Muik, Alexander, Sahin, Ugur, Türeci, Özlem, Pather, Shanti

“…The emergence of several new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent months has raised concerns around the potential…”
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Comorbidities in SARS-CoV-2 Patients: a Systematic Review and Meta-Analysis by Ng, Wern Hann, Tipih, Thomas, Makoah, Nigel A, Vermeulen, Jan-G, Goedhals, Dominique, Sempa, Joseph B, Burt, Felicity J, Taylor, Adam, Mahalingam, Suresh

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the globe at unprecedented speed and is showing no signs of slowing…”
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