Search Results - "le Pecq, J B"

Interaction of cationic porphyrins with DNA: importance of the number and position of the charges and minimum structural requirements for intercalation by Sari, M. A, Battioni, J. P, Dupre, D, Mansuy, D, Le Pecq, J. B

“…Thirty-three porphyrins or metalloporphyrins corresponding to the general formula [meso-[N-methyl-4(or 3 or 2)-pyridiniumyl]n(aryl)4-nporphyrin]M (M = H2,…”
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Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II by MARKOVITS, J, LINASSIER, C, FOSSE, P, COUPRIE, J, PIERRE, J, JACQUEMIN-SABLON, A, SAUCIER, J.-M, LE PECQ, J.-B, LARSEN, A. K

“…Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase-specific inhibitors might be…”
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Interaction of DNA intercalator 3-nitrobenzothiazolo (3,2-a)quinolinium with DNA topoisomerases: a possible-mechanism for its biological activity by Báez, A, Riou, J F, Le Pecq, J B, Riou, G

“…There is multiple evidence linking the inhibition of DNA topoisomerases I and II with the cytotoxic effects of antitumor drugs such as camptothecin and the DNA…”
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Modulation of the antitumor activity by methyl substitutions in the series of 7H-pyridocarbazole monomers and dimers by Leon, P, Garbay-Jaureguiberry, C, Barsi, M. C, Le Pecq, J. B, Roques, Bernard P

“…The structure of the dimeric antitumor drug ditercalinium (NSC 366241) [2,2'-([4,4'-bipiperidine]-1,1'-diyldi-2,1-ethanediyl)bis[10…”
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Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity by Linassier, C, Pierre, M, Le Pecq, J B, Pierre, J

“…Genistein has been shown to inhibit specifically in vitro the epidermal growth factor (EGF)-receptor tyrosine protein kinase activity (Akiyama et al., J Biol…”
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The Noncovalent Complex between DNA and the Bifunctional Intercalator Ditercalinium is a Substrate for the UvrABC Endonuclease of Escherichia coli by Lambert, Bernard, Jones, Beverly K., Roques, Bernard P., Le Pecq, Jean-Bernard, Yeung, Anthony T.

“…We have demonstrated that the noncovalent complex formed between DNA and an antitumor bifunctional intercalator, ditercalinium, is recognized in vitro as bulky…”
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Mode of interaction and apparent binding constants of meso-tetraaryl porphyrins bearing between one and four positive charges with DNA by Sari, M A, Battioni, J P, Mansuy, D, Le Pecq, J B

“…Meso-substituted porphyrins, ((4-N-methyl-pyridyl)n(Ph)4-n)PH2, n = 1 to 4, bearing between 1 and 4 positive charges have been synthetized and studied for…”
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Asymmetrical bisintercalators as potential antitumor agents by Leon, P, Garbay-Jaureguiberry, C, Lambert, B, Le Pecq, J. B, Roques, B. P

“…Ditercalinium and its analogues are dimeric molecules made up of two identical 7H-pyrido[4,3-c]carbazole rings linked by symmetrical linking chains. These…”
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Decay of Fluorescence Emission Anisotropy of the Ethidium Bromide-DNA Complex Evidence for an Internal Motion in DNA by Ph. Wahl, Paoletti, J., J.-B. Le Pecq

“…Evidence for an internal oscillatory Brownian motion in the DNA helix is obtained from the measurement of the decay of the fluorescence emission anisotropy of…”
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Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates by Rigaudy, P, Garbay-Jaureguiberry, C, Jacquemin-Sablon, A, Le Pecq, J B, Roques, B P

“…In order to specifically direct cytotoxic agents against tumor cells bearing delta opioid receptors, the DNA intercalating agents ellipticine and…”
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Structure-Activity Relationships in a Series of 5-[(2,5-Dihydroxybenzyl)amino]salicylate Inhibitors of EGF-Receptor-Associated Tyrosine Kinase: Importance of Additional Hydrophobic Aromatic Interactions by Chen, Huixiong, Boiziau, Janine, Parker, Fabienne, Mailliet, Patrick, Commercon, Alain, Tocque, Bruno, Le Pecq, Jean-Bernard, Roques, Bernard-Pierre, Garbay, Christiane

“…Potent inhibitors of EGF-dependent protein tyrosine kinase (PTK) activity were synthesized in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylates. Several of…”
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Dynamic structure of DNA complexes. Fluorometric measurement of hydrogen-deuterium exchange kinetics of DNA-bound ethidium dimer and acridine-ethidium dimer by Markovits, J, Ramstein, J, Roques, B. P, Le Pecq, J. B

“…The hydrogen-deuterium (H-D) exchange kinetics of free and DNA-bound ethidium dimer and acridine-ethidium heterodimer were measured by stopped flow using…”
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DNA Polyintercalating Drugs: DNA Binding of Diacridine Derivatives by Le Pecq, Jean-Bernard, Le Bret, Marc, Barbet, Jacques, Roques, Bernard

“…As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been…”
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Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c]carbazole antitumor series by Garbay-Jaureguiberry, C, Barsi, M. C, Jacquemin-Sablon, A, Le Pecq, J. B, Roques, B. P

“…Ditercalinium (NSC 366241) is a 7H-pyrido[4,3-c]carbazole dimer with a diethylbipiperidine rigid chain linking the two heterocyclic rings. Ditercalinium is…”
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Antitumor activity, pharmacology, and toxicity of ellipticines, ellipticinium, and 9-hydroxy derivatives: preliminary clinical trials of 2-methyl-9-hydroxy ellipticinium (NSC 264-137) by Paoletti, C, Le Pecq, J B, Dat-Xuong, N, Juret, P, Garnier, H, Amiel, J L, Rouesse, J

“…Ellipticine and some derivatives are highly cytotoxic substances which kill L1210 cells at concentrations ranging form 10(-8) to 10(-6)M. Some compounds in…”
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Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry by Soler, Françoise, Poujade, Christèle, Evers, Michel, Carry, Jean-Christophe, Hénin, Yvette, Bousseau, Anne, Huet, Thierry, Pauwels, Rudi, De Clercq, Erik, Mayaux, Jean-François, Le Pecq, Jean-Bernard, Dereu, Norbert

“…A novel series of ω-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus…”
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Betulinic Acid Derivatives:  A New Class of Human Immunodeficiency Virus Type 1 Specific Inhibitors with a New Mode of Action by Evers, Michel, Poujade, Christèle, Soler, Françoise, Ribeill, Yves, James, Claude, Lelièvre, Yves, Gueguen, Jean-Christophe, Reisdorf, Daniel, Morize, Isabelle, Pauwels, Rudi, De Clercq, Erik, Hénin, Yvette, Bousseau, Anne, Mayaux, Jean-François, Le Pecq, Jean-Bernard, Dereu, Norbert

“…A series of ω-undecanoic amides of lup-20(29)-en-28-oic acid derivatives were synthesized and evaluated for activity in CEM 4 and MT-4 cell cultures against…”
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DNase I susceptibility of bent DNA and its alteration by ditercalinium and distamycin by Mendoza, Roberto, Markovits, Judith, Jaffrezou, Jean Pierre, Muzard, Gabriel, Le Pecq, Jean Bernard

“…The bending of kinetoplast DNA from Crithidia fasciculata is thought to be related to the periodic distribution of AA or TT cluster sequences. The sensitivity…”
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Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells by Mayaux, J.F, Bousseau, A, Pauwells, R, Huet, T, Henin, Y, Dereu, N, Evers, M, Soler, F, Paujade, C, Clercq, E. de

“…A series of triterpene compounds characterized by a stringent structure-activity relationship were identified as potent and selective inhibitors of human…”
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Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection by Le Pecq, J B, Gosse, C, Nguyen-Dat-Xuong, Cros, S, Paoletti, C

“…The antitumor activity of a new derivative of ellipticine, 9-hydroxyellipticine (NSC 210717), was studied using L1210 mouse leukemia. Low doses of this drug…”
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