Search Results - "le Pecq, B"

Metastatic NSCLC: Clinical, molecular, and therapeutic factors associated with long-term survival by Asselain, B., Barrière, J.-R., Clarot, C., Vabre, J.-P., Gentil Le Pecq, B., Duval, Y., Thomas, P., Herman, D., Grivaux, M., Debieuvre, D.

“…Patients with metastatic non-small-cell lung cancer (NSCLC) who survive more than 2 years are considered long-term survivors (LTSs). The present study examined…”
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1037 One-year mortality in 6,101 non-small-cell lung cancers (NSCLCs) according to histology by Molinier, O, Goupil, F, Debieuvre, D, Clarot, C, Ménager, P, Dot, J.M, Carbonnelle, M, Barre, P, Tagu, P, Mahmoud, H, Figueredo, M, Bernier, C, Saillour, M, Romand, P, Gentil le Pecq, B, Fournier, E, Desurmont-Salasc, B, Perrichon, M, Blanchon, F, Grivaux, M

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Interaction of cationic porphyrins with DNA: importance of the number and position of the charges and minimum structural requirements for intercalation by Sari, M. A, Battioni, J. P, Dupre, D, Mansuy, D, Le Pecq, J. B

“…Thirty-three porphyrins or metalloporphyrins corresponding to the general formula [meso-[N-methyl-4(or 3 or 2)-pyridiniumyl]n(aryl)4-nporphyrin]M (M = H2,…”
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Respiratory complications of gastroplasty by an adjustable band by Kreuwen, A, Gentil-Le Pecq, B

“…Laparoscopic gastroplasty with an adjustable band is an efficient treatment of morbid obesity. Pulmonary complications have been rarely reported. We…”
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Modulation of the antitumor activity by methyl substitutions in the series of 7H-pyridocarbazole monomers and dimers by Leon, P, Garbay-Jaureguiberry, C, Barsi, M. C, Le Pecq, J. B, Roques, Bernard P

“…The structure of the dimeric antitumor drug ditercalinium (NSC 366241) [2,2'-([4,4'-bipiperidine]-1,1'-diyldi-2,1-ethanediyl)bis[10…”
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Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II by MARKOVITS, J, LINASSIER, C, FOSSE, P, COUPRIE, J, PIERRE, J, JACQUEMIN-SABLON, A, SAUCIER, J.-M, LE PECQ, J.-B, LARSEN, A. K

“…Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase-specific inhibitors might be…”
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The Noncovalent Complex between DNA and the Bifunctional Intercalator Ditercalinium is a Substrate for the UvrABC Endonuclease of Escherichia coli by Lambert, Bernard, Jones, Beverly K., Roques, Bernard P., Le Pecq, Jean-Bernard, Yeung, Anthony T.

“…We have demonstrated that the noncovalent complex formed between DNA and an antitumor bifunctional intercalator, ditercalinium, is recognized in vitro as bulky…”
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Interaction of DNA intercalator 3-nitrobenzothiazolo (3,2-a)quinolinium with DNA topoisomerases: a possible-mechanism for its biological activity by Báez, A, Riou, J F, Le Pecq, J B, Riou, G

“…There is multiple evidence linking the inhibition of DNA topoisomerases I and II with the cytotoxic effects of antitumor drugs such as camptothecin and the DNA…”
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Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity by Linassier, C, Pierre, M, Le Pecq, J B, Pierre, J

“…Genistein has been shown to inhibit specifically in vitro the epidermal growth factor (EGF)-receptor tyrosine protein kinase activity (Akiyama et al., J Biol…”
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Asymmetrical bisintercalators as potential antitumor agents by Leon, P, Garbay-Jaureguiberry, C, Lambert, B, Le Pecq, J. B, Roques, B. P

“…Ditercalinium and its analogues are dimeric molecules made up of two identical 7H-pyrido[4,3-c]carbazole rings linked by symmetrical linking chains. These…”
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Mode of interaction and apparent binding constants of meso-tetraaryl porphyrins bearing between one and four positive charges with DNA by Sari, M A, Battioni, J P, Mansuy, D, Le Pecq, J B

“…Meso-substituted porphyrins, ((4-N-methyl-pyridyl)n(Ph)4-n)PH2, n = 1 to 4, bearing between 1 and 4 positive charges have been synthetized and studied for…”
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Decay of Fluorescence Emission Anisotropy of the Ethidium Bromide-DNA Complex Evidence for an Internal Motion in DNA by Ph. Wahl, Paoletti, J., J.-B. Le Pecq

“…Evidence for an internal oscillatory Brownian motion in the DNA helix is obtained from the measurement of the decay of the fluorescence emission anisotropy of…”
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Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates by Rigaudy, P, Garbay-Jaureguiberry, C, Jacquemin-Sablon, A, Le Pecq, J B, Roques, B P

“…In order to specifically direct cytotoxic agents against tumor cells bearing delta opioid receptors, the DNA intercalating agents ellipticine and…”
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DNA Polyintercalating Drugs: DNA Binding of Diacridine Derivatives by Le Pecq, Jean-Bernard, Le Bret, Marc, Barbet, Jacques, Roques, Bernard

“…As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been…”
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Structure-Activity Relationships in a Series of 5-[(2,5-Dihydroxybenzyl)amino]salicylate Inhibitors of EGF-Receptor-Associated Tyrosine Kinase: Importance of Additional Hydrophobic Aromatic Interactions by Chen, Huixiong, Boiziau, Janine, Parker, Fabienne, Mailliet, Patrick, Commercon, Alain, Tocque, Bruno, Le Pecq, Jean-Bernard, Roques, Bernard-Pierre, Garbay, Christiane

“…Potent inhibitors of EGF-dependent protein tyrosine kinase (PTK) activity were synthesized in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylates. Several of…”
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Acridine dimers: influence of the intercalating ring and of the linking‐chain nature on the equilibrium and kinetic DNA‐binding parameters by MARKOVITS, Judith, GARBAY‐JAUREGUIBERRY, Christiane, ROQUES, Bernard P., PECQ, Jean‐Bernard

“…The rigidity of the linking chain of bifunctional intercalators in the ditercalinium series was shown to be critical for antitumor activity. In order to study…”
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Dynamic structure of DNA complexes. Fluorometric measurement of hydrogen-deuterium exchange kinetics of DNA-bound ethidium dimer and acridine-ethidium dimer by Markovits, J, Ramstein, J, Roques, B. P, Le Pecq, J. B

“…The hydrogen-deuterium (H-D) exchange kinetics of free and DNA-bound ethidium dimer and acridine-ethidium heterodimer were measured by stopped flow using…”
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Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c]carbazole antitumor series by Garbay-Jaureguiberry, C, Barsi, M. C, Jacquemin-Sablon, A, Le Pecq, J. B, Roques, B. P

“…Ditercalinium (NSC 366241) is a 7H-pyrido[4,3-c]carbazole dimer with a diethylbipiperidine rigid chain linking the two heterocyclic rings. Ditercalinium is…”
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Antitumor activity, pharmacology, and toxicity of ellipticines, ellipticinium, and 9-hydroxy derivatives: preliminary clinical trials of 2-methyl-9-hydroxy ellipticinium (NSC 264-137) by Paoletti, C, Le Pecq, J B, Dat-Xuong, N, Juret, P, Garnier, H, Amiel, J L, Rouesse, J

“…Ellipticine and some derivatives are highly cytotoxic substances which kill L1210 cells at concentrations ranging form 10(-8) to 10(-6)M. Some compounds in…”
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Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry by Soler, Françoise, Poujade, Christèle, Evers, Michel, Carry, Jean-Christophe, Hénin, Yvette, Bousseau, Anne, Huet, Thierry, Pauwels, Rudi, De Clercq, Erik, Mayaux, Jean-François, Le Pecq, Jean-Bernard, Dereu, Norbert

“…A novel series of ω-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus…”
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