Search Results - "khattab, Mahmoud M."

Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway by Kamel, Ahmed S., Abdelkader, Noha F., Abd El-Rahman, Sahar S., Emara, Marwan, Zaki, Hala F., Khattab, Mahmoud M.

“…Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and…”
Get full text

Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor by Mansour, Heba M., Mohamed, Ahmed F., Khattab, Mahmoud. M., El-Khatib, Aiman S.

“…[Display omitted] •EGFR inhibitor lapatinib exerts neuroprotective effects in PD.•Modulation of dopamine D3 receptors may have therapeutic potential in…”
Get full text

Heat Shock Protein 90 in Parkinson's Disease: Profile of a Serial Killer by Mansour, Heba M, Mohamed, Ahmed F, Khattab, Mahmoud M, El-Khatib, Aiman S

“…Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by abnormal α-synuclein misfolding and aggregation, mitochondrial…”
Get full text

Targeting the Oxytocin System to Ameliorate Early Life Depressive-Like Behaviors in Maternally-Separated Rats by Abdelwahab, Lobna A., Galal, Omneya O., El-Rahman, Sahar S. Abd, El-Brairy, Amany I., Khattab, Mahmoud M., El-Khatib, Aiman S.

“…Oxytocin (OXT) —“the love hormone”— has been involved in the anti-depressant activity of some selective serotonin reuptake inhibitors (SSRIs). The exact…”
Get full text

Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice by Ahmed, Lamiaa A, Shehata, Nagwa I, Abdelkader, Noha F, Khattab, Mahmoud M

“…Mitochondrial dysfunction is a crucial mechanism by which cisplatin, a potent chemotherapeutic agent, causes nephrotoxicity where mitochondrial electron…”
Get full text

In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue by Abo-zalam, Hagar B., Abdelsalam, Rania M., Abdel-Rahman, Rehab F., Abd-Ellah, Mohamed F., Khattab, Mahmoud M.

“…Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In…”
Get full text

Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study by Abo-zalam, Hagar B., El-Denshary, Ezzeldein S., Abdelsalam, Rania M., Khalil, Islam A., Khattab, Mahmoud M., Hamzawy, Mohamed A.

“…This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects…”
Get full text

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer's disease by Mansour, Heba, Fawzy, Hala, El-Khatib, Aiman, Khattab, Mahmoud

“…Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer's…”
Get full text

Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis by Abuohashish, Hatem M., Ahmed, Mohammed M., Sabry, Dina, Khattab, Mahmoud M., Al-Rejaie, Salim S.

“…The local and systemic renin angiotensin system (RAS) influences the skeletal system micro-structure and metabolism. Studies suggested angiotensin 1-7…”
Get full text

Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors by Kamel, Ahmed S, Mohamed, Ahmed F, Rabie, Mostafa A, Elsherbiny, Marwa E, Ahmed, Kawkab A, Khattab, Mahmoud M, Abdelkader, Noha F

“…Though quinoline anti-infective agents-associated neurotoxicity has been reported in the early 1970s, it only recently received regulatory recognition. In…”
Get full text

Integrated Mediapipe with a CNN Model for Arabic Sign Language Recognition by Moustafa, Ahmad M. J. AL, Mohd Rahim, Mohd Shafry, Bouallegue, Belgacem, Khattab, Mahmoud M., Soliman, Amr Mohmed, Tharwat, Gamal, Ahmed, Abdelmoty M.

“…Deaf and dumb people struggle with communicating on a day-to-day basis. Current advancements in artificial intelligence (AI) have allowed this communication…”
Get full text

Regularized Multiframe Super-Resolution Image Reconstruction Using Linear and Nonlinear Filters by Khattab, Mahmoud M., Zeki, Akram M., Alwan, Ali A., Bouallegue, Belgacem, Matter, Safaa S., Ahmed, Abdelmoty M.

“…The primary goal of the multiframe super-resolution image reconstruction is to produce an image with a higher resolution by integrating information extracted…”
Get full text

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect by Mahmoud, Mohamed A. Aziz, Saleh, Dalia O., Safar, Marwa M., Agha, Azza M., Khattab, Mahmoud M.

“…[Display omitted] •Cloroquine (CQ) has reduced the adverse bone changes caused by d-galactose.•It improved bone health, switched off nuclear factor kappa-B…”
Get full text

Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer’s Disease: Current Perspectives and Challenging Prospects by Mansour, Heba M., Fawzy, Hala M., El-Khatib, Aiman S., Khattab, Mahmoud M.

“…[Display omitted] •New therapeutic approaches have to be considered in Alzheimer’s disease (AD).•Pathways regulating cell duplication are significant…”
Get full text

Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease by Mansour, Heba M., F Mohamed, Ahmed, Khattab, Mahmoud M., El-Khatib, Aiman S.

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death in the substantia nigra (SN)…”
Get full text

Lapatinib ditosylate rescues memory impairment in D-galactose/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer's disease by Mansour, Heba M., Fawzy, Hala M., El-Khatib, Aiman S., Khattab, Mahmoud M.

“…Epidermal growth factor receptor (EGFR) signaling plays a substantial role in learning and memory. The upregulation of EGFR has been embroiled in the…”
Get full text

Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms by Mansour, Heba M., Mohamed, Ahmed F., Khattab, Mahmoud M., El-Khatib, Aiman S.

“…Parkinson’s disease (PD) is characterized by motor impairments and progressive dopaminergic neuronal death in the substantia nigra (SN). Recently, the…”
Get full text

Telmisartan/17β-estradiol mitigated cognitive deficit in an ovariectomized rat model of Alzheimer's disease: Modulation of ACE1/ACE2 and AT1/AT2 ratio by Abdelkader, Noha F., Abd El-Latif, Aya M., Khattab, Mahmoud M.

“…The higher incidence rate of Alzheimer's disease (AD) among women has led to explorations on the association between estrogen deficiency and AD. Also, usage of…”
Get full text

Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways by Ibrahim, Weam W., Abdelkader, Noha F., Ismail, Hesham M., Khattab, Mahmoud M.

“…Though selective serotonin reuptake inhibitors (SSRIs) have been found to increase cognitive performance in some studies on patients and animal models of…”
Get full text

Corrigendum to “Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease” [Eur. J. Pharmacol. 954 (2023) 175875] by Mansour, Heba M., Mohamed, Ahmed F., Khattab, Mahmoud M., El-Khatib, Aiman S.

Get full text