Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia

Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in pati...

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Published in:Non-coding RNA research Vol. 8; no. 4; pp. 481 - 486
Main Authors: Ayoub, Shymaa E., Shaker, Olfat G., Aboshama, Rehab Abdelhamid, Etman, Mohamed K., Khalefa, Abeer A., khamiss Abd elguaad, Mohamed M., Zaki, Othman M., Ali, Doaa Y., Hemeda, Nada F., Amin, Amal, Ali, Marwa A.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-12-2023
KeAi Publishing
KeAi Communications Co., Ltd
Subjects:
LncRNA ANRIL
miR-181a
miR-186
MTMR-3
Original
Preeclampsia
miR-181a
MTMR-3
LncRNA ANRIL
miR-186
Preeclampsia
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Summary:Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia. The study included 160 subjects divided into 80 subjects considered as a control group, 80 patients with preeclampsia. We found that there was a significant difference between the preeclampsia and control groups with up-regulation of miR-186 median (IQR) = 4, 29 (1.35–7.73) (P < 0.0001), miR-181a median (IQR) = 2.45 (0.83–6.52) (P = 0.028), and downregulation of lncRNA ANRIL median (IQR) = 0.35(0.28–0.528) (P < 0.0001), MTMR median (IQR) = 0.32(0.155–1.11), (P < 0.0001). ROC curve of lncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in preeclampsia patients showing the roles of these markers in the diagnosis of preeclampsia. In conclusion, serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 could be promising biomarkers in the diagnosis of preeclampsia.
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ISSN:2468-0540
2468-0540
DOI:10.1016/j.ncrna.2023.06.001