Search Results - "heckle, mark"

Withdrawal: Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration by Gadepalli, Ravisekhar, Kotla, Sivareddy, Heckle, Mark R., Verma, Shailendra K., Singh, Nikhlesh K., Rao, Gadiparthi N.

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The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis by Kotla, Sivareddy, Singh, Nikhlesh K, Heckle, Mark R, Tigyi, Gabor J, Rao, Gadiparthi N

“…The enzyme 15-lipoxygenase (15-LO) plays a role in atherogenesis (also known as atherosclerosis), but the underlying mechanisms are unclear. We found that…”
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Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration by Gadepalli, Ravisekhar, Kotla, Sivareddy, Heckle, Mark R., Verma, Shailendra K., Singh, Nikhlesh K., Rao, Gadiparthi N.

“…To understand the role of thrombin in inflammation, we tested its effects on migration of THP-1 cells, a human monocytic cell line. Thrombin induced THP-1 cell…”
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Cannabinoids and Symptomatic Bradycardia by Heckle, Mark R., MD, Nayyar, Mannu, MD, Sinclair, Scott E., MD, Weber, Karl T., MD

“…Abstract Cannabinoids, the bioactive components of marijuana, have adverse cardiovascular consequences, including symptomatic sinus bradycardia, sinus arrest…”
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A comprehensive meta‐analysis of randomized controlled trials comparing drug‐eluting stents with bare‐metal stents in saphenous vein graft interventions by Shah, Rahman, Jovin, Ion S., Latham, Samuel B., Hesterberg, Kirstin, Heckle, Mark R., Rashid, Abdul, Vetrovec, George W.

“…Background Several large randomized controlled trials (RCTs) have proven the superiority of drug‐eluting stents (DESs) over bare‐metal stents (BMSs) for native…”
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Percutaneous Left Atrial Appendage Closure: Review of Anatomy, Imaging, and Outcomes by Pour-Ghaz, Issa, Heckle, Mark R., Maturana, Miguel, Seitz, Michael P., Zare, Pegah, Khouzam, Rami N., Kabra, Rajesh

“…Purpose of review Percutaneous left atrial appendage closure (LAAC) with WATCHMAN (Boston Scientific Inc.) has emerged as a viable non-pharmacological…”
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Protein Kinase N1 Is a Novel Substrate of NFATc1-mediated Cyclin D1-CDK6 Activity and Modulates Vascular Smooth Muscle Cell Division and Migration Leading to Inward Blood Vessel Wall Remodeling by Singh, Nikhlesh K., Kundumani-Sridharan, Venkatesh, Kumar, Sanjay, Verma, Shailendra K., Kotla, Sivareddy, Mukai, Hideyuki, Heckle, Mark R., Rao, Gadiparthi N.

“…Toward understanding the mechanisms of vascular wall remodeling, here we have studied the role of NFATc1 in MCP-1-induced human aortic smooth muscle cell…”
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Outcomes of Early Versus Delayed Transcatheter Closure of Post-Myocardial Infarction Ventricular Septal Defect by Heckle, Mark R., Brooksbank, Jeremy A., Agarwal, Manyoo A., Ibebuogu, Uzoma N.

“…Post myocardial infarction ventricular septal defect (VSD) is a rare, but devastating complication which carries a poor prognosis if left untreated. Optimal…”
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Ablation Therapy for Persistent Atrial Fibrillation by Ifedili, Ikechukwu, Mouksian, Kristina, Jones, David, El Masri, Ibrahim, Heckle, Mark, Jefferies, John, Levine, Yehoshua C

“…Atrial Fibrillation (AF) is the most common form of electrical disturbance of the heartand contributes to significant patient morbidity and mortality. With a…”
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Simultaneous acute cardio-cerebral infarction: is there a consensus for management? by Akinseye, Oluwaseun A, Shahreyar, Muhammad, Heckle, Mark R, Khouzam, Rami N

“…Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) are both life-threatening medical conditions with narrow therapeutic time-window that carry…”
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Stress-induced thrombus: prevalence of thromboembolic events and the role of anticoagulation in Takotsubo cardiomyopathy by Heckle, Mark R, McCoy, Cody W, Akinseye, Oluwaseun A, Khouzam, Rami N

“…Takotsubo cardiomyopathy (TCM), also known as stress-induced cardiomyopathy has a favorable prognosis with expected recovery in weeks. Left ventricular (LV)…”
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Myofibroblast secretome and its auto-/paracrine signaling by Bomb, Ritin, Heckle, Mark R, Sun, Yao, Mancarella, Salvatore, Guntaka, Ramareddy V, Gerling, Ivan C, Weber, Karl T

“…Myofibroblasts (myoFb) are phenotypically transformed, contractile fibroblast-like cells expressing α-smooth muscle actin microfilaments. They are integral to…”
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Novel Role of Proline-Rich Nonreceptor Tyrosine Kinase 2 in Vascular Wall Remodeling After Balloon Injury by Gadepalli, Ravisekhar, Singh, Nikhlesh K, Kundumani-Sridharan, Venkatesh, Heckle, Mark R, Rao, Gadiparthi N

“…OBJECTIVE—To investigate the role of Pyk2, a proline-rich nonreceptor tyrosine kinase, in G protein−coupled receptor agonist, thrombin-induced human aortic…”
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Outcomes of transcatheter aortic valve replacement in bicuspid aortic valve stenosis by Bob-Manuel, Tamunoinemi, Heckle, Mark R, Ifedili, Ikechukwu A, Wang, Jiajing, Ibebuogu, Uzoma N

“…Due to abnormal valve geometry, patients with bicuspid aortic valve (BAV) have been excluded in many transcatheter aortic valve replacement (TAVR) trials…”
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Accurate Prediction of False ST-Segment Elevation Myocardial Infarction: Ready for Prime Time? by Heckle, Mark R., Efeovbokhan, Nephertiti, Thomas, Fridjof, Blumer, Mary, Chumpia, Mason, Ibebuogu, Uzoma, Reed, Guy L., Khouzam, Rami N.

“…The incidence of inappropriate cardiac catheterization lab activation for treatment of a false ST-segment elevation myocardial infarction (STEMI) has been…”
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Atrophied cardiomyocytes and their potential for rescue and recovery of ventricular function by Heckle, Mark R., Flatt, David M., Sun, Yao, Mancarella, Salvatore, Marion, Tony N., Gerling, Ivan C., Weber, Karl T.

“…Cardiomyocytes must be responsive to demands placed on the heart’s contractile work as a muscular pump. In turn, myocyte size is largely dependent on the…”
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Outcomes following transcatheter aortic valve replacement in patients with native aortic valve regurgitation by Bob-Manuel, Tamunoinemi, Kadire, Siri, Heckle, Mark R, Wang, Jiajing, Ibebuogu, Uzoma N

“…Due to the absence of annular calcification for device anchoring, it is presumed that transcatheter aortic valve replacement (TAVR) is not suitable for the…”
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Racial Difference in Symptom Onset to Door Time in ST Elevation Myocardial Infarction by Bolorunduro, Oluwaseyi, Smith, Blake, Chumpia, Mason, Valasareddy, Poojitha, Heckle, Mark R., Khouzam, Rami N., Reed, Guy L., Ibebuogu, Uzoma N.

“…Background There are poorer outcomes following ST elevation myocardial infarction in blacks compared to white patients despite comparable door‐to‐reperfusion…”
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Impact of Pre-existing Kidney Dysfunction on Outcomes Following Transcatheter Aortic Valve Replacement by Ifedili, Ikechukwu A, Bolorunduro, Oluwaseyi, Bob-Manuel, Tamunoinemi, Heckle, Mark R, Christian, Ellis, Kar, Saibal, Ibebuogu, Uzoma N

“…Background: Pre-existing chronic kidney disease (CKD) portends adverse outcomes following heart valve surgery. However, only limited and conflicting evidence…”
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A Case of Isolated Coronary Artery Ectasia in the Setting of Chronic Inflamation From human Immunodeficiency Virus Infection by Heckle, Mark R, Askari, Raza, Morsy, Mohamed, Ibebuogu, Uzoma N

“…Coronary artery ectasia also known as dilated coronopathy is a relatively rare finding that is most commonly associated with atherosclerosis. Several…”
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