Search Results - "getta, Vincenzo"

Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening by Lu, Tianyuan, Zhou, Sirui, Wu, Haoyu, Forgetta, Vincenzo, Greenwood, Celia M. T., Richards, J. Brent

“…Purpose Identifying rare genetic causes of common diseases can improve diagnostic and treatment strategies, but incurs high costs. We tested whether…”
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Childhood obesity and multiple sclerosis: A Mendelian randomization study by Harroud, Adil, Mitchell, Ruth E, Richardson, Tom G, Morris, John A, Forgetta, Vincenzo, Davey Smith, George, Baranzini, Sergio E, Richards, J Brent

“…Background: Higher childhood body mass index (BMI) has been associated with an increased risk of multiple sclerosis (MS). Objective: To evaluate whether…”
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Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci by Manousaki, Despoina, Mitchell, Ruth, Dudding, Tom, Haworth, Simon, Harroud, Adil, Forgetta, Vincenzo, Shah, Rupal L., Luan, Jian’an, Langenberg, Claudia, Timpson, Nicholas J., Richards, J. Brent

“…We aimed to increase our understanding of the genetic determinants of vitamin D levels by undertaking a large-scale genome-wide association study (GWAS) of…”
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Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study by Yazdanpanah, Nahid, Yazdanpanah, Mojgan, Wang, Ye, Forgetta, Vincenzo, Pollak, Michael, Polychronakos, Constantin, Richards, J Brent, Manousaki, Despoina

“…To identify circulating proteins influencing type 1 diabetes susceptibility using Mendelian randomization (MR). We used a large-scale two-sample MR study,…”
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Genetically decreased vitamin D and risk of Alzheimer disease by Mokry, Lauren E, Ross, Stephanie, Morris, John A, Manousaki, Despoina, Forgetta, Vincenzo, Richards, J Brent

“…OBJECTIVE:To test whether genetically decreased vitamin D levels are associated with Alzheimer disease (AD) using mendelian randomization (MR), a method that…”
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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases by Chen, Yiheng, Lu, Tianyuan, Pettersson-Kymmer, Ulrika, Stewart, Isobel D., Butler-Laporte, Guillaume, Nakanishi, Tomoko, Cerani, Agustin, Liang, Kevin Y. H., Yoshiji, Satoshi, Willett, Julian Daniel Sunday, Su, Chen-Yang, Raina, Parminder, Greenwood, Celia M. T., Farjoun, Yossi, Forgetta, Vincenzo, Langenberg, Claudia, Zhou, Sirui, Ohlsson, Claes, Richards, J. Brent

“…Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and…”
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A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity by Zhou, Sirui, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Morrison, David R., Afilalo, Jonathan, Afilalo, Marc, Laurent, Laetitia, Pietzner, Maik, Kerrison, Nicola, Zhao, Kaiqiong, Brunet-Ratnasingham, Elsa, Henry, Danielle, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Bouab, Meriem, Petitjean, Louis, Guzman, Charlotte, Xue, Xiaoqing, Tselios, Chris, Vulesevic, Branka, Adeleye, Olumide, Abdullah, Tala, Almamlouk, Noor, Chen, Yiheng, Chassé, Michaël, Durand, Madeleine, Paterson, Clare, Normark, Johan, Frithiof, Robert, Lipcsey, Miklós, Hultström, Michael, Greenwood, Celia M. T., Zeberg, Hugo, Langenberg, Claudia, Thysell, Elin, Pollak, Michael, Mooser, Vincent, Forgetta, Vincenzo, Kaufmann, Daniel E., Richards, J. Brent

“…To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization…”
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Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study by Lu, Tianyuan, Forgetta, Vincenzo, Greenwood, Celia M.T., Zhou, Sirui, Richards, J. Brent

“…There is a pressing need for novel drug targets for psychiatric disorders. Circulating proteins are potential candidates because they are relatively easy to…”
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Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases by Lu, Tianyuan, Forgetta, Vincenzo, Richards, John Brent, Greenwood, Celia M.T.

“…The study aimed to evaluate whether polygenic risk scores could be helpful in addition to family history for triaging individuals to undergo deep-depth…”
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The undiagnosed disease burden associated with alpha-1 antitrypsin deficiency genotypes by Nakanishi, Tomoko, Forgetta, Vincenzo, Handa, Tomohiro, Hirai, Toyohiro, Mooser, Vincent, Lathrop, G Mark, Cookson, William O C M, Richards, J Brent

“…Alpha-1 antitrypsin deficiency (AATD), mainly due to the PI*ZZ genotype in , is one of the most common inherited diseases. Since it is associated with a high…”
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Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study by Lu, Tianyuan, Chen, Yiheng, Yoshiji, Satoshi, Ilboudo, Yann, Forgetta, Vincenzo, Zhou, Sirui, Greenwood, Celia M.T.

“…Preventive measures and treatments for psychiatric disorders are limited. Circulating metabolites are potential candidates for biomarker and therapeutic target…”
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An atlas of genetic influences on human blood metabolites by Shin, So-Youn, Fauman, Eric B, Petersen, Ann-Kristin, Krumsiek, Jan, Santos, Rita, Huang, Jie, Arnold, Matthias, Erte, Idil, Forgetta, Vincenzo, Yang, Tsun-Po, Walter, Klaudia, Menni, Cristina, Chen, Lu, Vasquez, Louella, Valdes, Ana M, Hyde, Craig L, Wang, Vicky, Ziemek, Daniel, Roberts, Phoebe, Xi, Li, Grundberg, Elin, Waldenberger, Melanie, Richards, J Brent, Mohney, Robert P, Milburn, Michael V, John, Sally L, Trimmer, Jeff, Theis, Fabian J, Overington, John P, Suhre, Karsten, Brosnan, M Julia, Gieger, Christian, Kastenmüller, Gabi, Spector, Tim D, Soranzo, Nicole

“…Nicole Soranzo, Tim Spector, Gabi Kastenmüller and colleagues report a large-scale analysis of genetic variants influencing human blood metabolite levels. They…”
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Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study by Mokry, Lauren E, Ross, Stephanie, Ahmad, Omar S, Forgetta, Vincenzo, Smith, George Davey, Goltzman, David, Leong, Aaron, Greenwood, Celia M T, Thanassoulis, George, Richards, J Brent

“…Observational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains unclear…”
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Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes by Forgetta, Vincenzo, Manousaki, Despoina, Istomine, Roman, Ross, Stephanie, Tessier, Marie-Catherine, Marchand, Luc, Li, Min, Qu, Hui-Qi, Bradfield, Jonathan P, Grant, Struan F A, Hakonarson, Hakon, Paterson, Andrew D, Piccirillo, Ciriaco, Polychronakos, Constantin, Richards, J Brent

“…Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF…”
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Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis by Kemp, John P, Morris, John A, Medina-Gomez, Carolina, Forgetta, Vincenzo, Warrington, Nicole M, Youlten, Scott E, Zheng, Jie, Gregson, Celia L, Grundberg, Elin, Trajanoska, Katerina, Logan, John G, Pollard, Andrea S, Sparkes, Penny C, Ghirardello, Elena J, Allen, Rebecca, Leitch, Victoria D, Butterfield, Natalie C, Komla-Ebri, Davide, Adoum, Anne-Tounsia, Curry, Katharine F, White, Jacqueline K, Kussy, Fiona, Greenlaw, Keelin M, Xu, Changjiang, Harvey, Nicholas C, Cooper, Cyrus, Adams, David J, Greenwood, Celia M T, Maurano, Matthew T, Kaptoge, Stephen, Rivadeneira, Fernando, Tobias, Jonathan H, Croucher, Peter I, Ackert-Bicknell, Cheryl L, Bassett, J H Duncan, Williams, Graham R, Richards, J Brent, Evans, David M

“…David Evans, Brent Richards and colleagues carried out a genome-wide association study in 142,487 individuals from the UK Biobank and identified 153 new loci…”
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Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study by Butler-Laporte, Guillaume, Nakanishi, Tomoko, Mooser, Vincent, Morrison, David R, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Giliberti, Annarita, Renieri, Alessandra, Chen, Yiheng, Zhou, Sirui, Forgetta, Vincenzo, Richards, J Brent

“…Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro,…”
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Mendelian randomisation applied to drug development in cardiovascular disease: a review by Mokry, Lauren E, Ahmad, Omar, Forgetta, Vincenzo, Thanassoulis, George, Richards, J Brent

“…Despite increased expenditure, productivity of the pharmaceutical industry has decreased and currently 90% of developed molecules entering phase II and phase…”
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Genetic determinants of polygenic prediction accuracy within a population by Lu, Tianyuan, Forgetta, Vincenzo, Richards, John Brent, Greenwood, Celia M T

“…Abstract Genomic risk prediction is on the emerging path toward personalized medicine. However, the accuracy of polygenic prediction varies strongly in…”
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Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk by Lu, Tianyuan, Forgetta, Vincenzo, Zhou, Sirui, Richards, J Brent, Greenwood, Celia MT

“…ABSTRACT Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical…”
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Genetic susceptibility and late bone outcomes in childhood acute lymphoblastic leukemia survivors by Geneviève, Nadeau, Mojgan, Yazdanpanah, Nahid, Yazdanpanah, Vincenzo, Forgetta, Simon, Girard, Daniel, Sinnett, Maja, Krajinovic, Nathalie, Alos, Despoina, Manousaki

“…Childhood acute lymphoblastic leukemia (cALL) survivors are at increased risk for bone comorbidities, but accurate screening tools for such comorbidities are…”
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